A5049842965- Synthesis and biological activity
- Computational Drug Discovery Methods
- Synthesis and Biological Evaluation
- Research on Leishmaniasis Studies
- Natural Antidiabetic Agents Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer therapeutics and mechanisms
- SARS-CoV-2 and COVID-19 Research
- Click Chemistry and Applications
- Inflammatory mediators and NSAID effects
- Bioactive Compounds and Antitumor Agents
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Reactions of Organic Compounds
- Tuberculosis Research and Epidemiology
- Enzyme function and inhibition
- Genetics, Bioinformatics, and Biomedical Research
- Trypanosoma species research and implications
- Alzheimer's disease research and treatments
- Toxin Mechanisms and Immunotoxins
- Tannin, Tannase and Anticancer Activities
- Nail Diseases and Treatments
- Pharmacological Effects of Medicinal Plants
- Malaria Research and Control
- Advanced Glycation End Products research
- Medicinal Plants and Neuroprotection
Indo Soviet Friendship College of Pharmacy
2024-2025
Delhi Pharmaceutical Science and Research University
2021-2024
Friendship College
2024
Jamia Hamdard
2016-2022
Mankind Pharma (India)
2020
This work evaluates nano-lipid carrier of ganoderic acid (GA) and molecular docking on various cancer signaling pathways, an attempt to improve the hepatic condition associated with carcinoma (HCC) induced by diethyl-nitrosamine (DEN) in Wistar rats. Molecular mechanism GA was performed through binding simulation analysis for pathway, viz., Bcl-2, Pl3K, NF-κB, Akt/PKB, Stat-3. Double emulsion solvent displacement method implied preparation GA-loaded carrier. GA-NLCs were evaluated drug...
Abstract Background Natural products use for arthritis treatment is gaining importance in the medical worldt. Various studies reports of Melastoma malabathricum Linn . ( MM ) (Melastomataceae), also known as “putki,” has a broad range health benefits, its free radical scavenging constituents. The current investigation scrutinizes antioxidant and anti-inflammatory effect against adjuvant-induced experimental rats. Methods High-performance thin layer chromatography (HPTLC) was used estimation...
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the disease 19 (COVID-19) pandemic. Despite unprecedented research and developmental efforts, SARS-CoV-2-specific antivirals are still unavailable treatment COVID-19. In most instances, SARS-CoV-2 infection initiates with binding Spike glycoprotein to host cell ACE2 receptor. Utilizing crystal structure ACE2/Spike receptor-binding domain (S-RBD) complex (PDB file 6M0J) in a computer-aided drug...
Abstract: Diabetes is a chronic metabolic disease of high levels glucose in the blood and affecting 536.6 million people world between age group 20-79 with management spent 11% total worldwide. Wound healing diabetics impaired due to many factors like sugar, poor circulation, damaged vessels, diabetic neuropathy, decreased immune responses etc. The presently used synthetic drugs have costs, toxic nature, are full adverse effects drawing attention need identify new successful treatment...
Cysteine proteases are essential for the survival of Leishmania parasites that cause several clinical forms leishmaniases. Inhibiting cysteine protease can be a promising strategy against parasitic diseases because their functions in life cycles these pathogens. The aim present study was to synthesize and evaluate peptidyl -nitrostyrenes as antipromastigote inhibitors donovani promastigotes. A library 12 β-nitrostyrenes synthesized evaluated anti-promastigote activity. Most compounds...
has a long history of use in the Indian Ayurvedic System Medicine for treatment, prevention, and cure diverse range human diseases such as diabetes obesity, other metabolic diseases. A wide chemical constituents, triterpenoid saponin, kauren diterpene, coumestans, been isolated from plant. Conversely, no published literature is available relation to isolation wedelolactone (WEL) its anti-diabetic effect. The aim present study was isolate bioactive phyto-constituent
The objective of this study was to evaluate the anticancer effects Melstoma malabathricum L. (MM) MDA-MB-231 human breast cancer and in vivo mammary tumor model decipher potential mechanism. phyto-constituents extract have been identified by liquid chromatography-mass spectrometry (LC–MS). anti-cancer activity MM tested on cells. Chemical carcinogen 7,12-dimethylbenz(a)anthracene (DMBA) used for induction rodents. Burden, volume, incidence, pro-inflammatory cytokines, antioxidant parameters...
Prunus amygdalus (PA) is a popular invasive seed utilized in the management of diabetes Jammu and Kashmir, India. The objective current study was to scrutinize antidiabetic effect against Streptozotocin (STZ) induced diabetic rats explore possible mechanism action at cellular sub-cellular levels. Box Benkan Design (BBD) performed determine PA powder methanol, extraction time temperature on DPPH ABTS free radical scavenging activity decoction. In-silico GLUT1 (5EQG) dipeptidyl peptidase IV...
Six 1,4-benzothiazin-3-ones (2a-f) and four benzothiazinyl acetate derivatives (3a-d) were synthesized characterized by various spectroscopic methods, namely, 1H NMR, 13C IR, MS, elemental analysis. The cytotoxic effects of the compounds assessed against MCF-7, a human breast cancer cell line, along with their anti-inflammatory activity. Molecular docking studies performed VEGFR2 kinase receptor displayed common binding orientation in catalytic pocket receptor. generalized Born surface area...
Abstract Antimalarial drug resistance has emerged as a threat for treating malaria, generating need to design and develop newer, more efficient antimalarial agents. This research aimed identify novel leads antimalarials. Dual receptor mechanism could be good strategy combat developing resistance. A series of benzimidazole acrylonitriles containing 18 compounds were designed, synthesized evaluated cytotoxicity, heme binding, ferriprotoporphyrin IX biomineralisation inhibition, falcipain‐2...
BA.2, a sublineage of Omicron BA.1, is now prominent in many parts the world. Early reports have indicated that BA.2 more infectious than BA.1. To gain insight into mutation profile and resulting impact mutations on interactions with receptor and/or monoclonal antibodies, we analyzed available sequences, structures Spike/receptor Spike/antibody complexes, conducted molecular dynamics simulations. The results showed had 50 high-prevalent mutations, compared to 48 Additionally, 17 BA.1 were...
Background: Mining of novel scaffolds as potential DPP-IV inhibitors for future development candidates antidiabetic agents to address global issues. Methodology: The identified hit KB-10 from a previously reported study was taken lead designing library analogues and screened initially based on in silico parameters docking score. A series selected (2[4-(1-acetyl-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenoxy]-1-phenylethanone derivatives were synthesized evaluated through vitro studies....