A5036235908- Smoking Behavior and Cessation
- Air Quality and Health Impacts
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Telomeres, Telomerase, and Senescence
- Advanced Glycation End Products research
- COVID-19 Clinical Research Studies
- Indoor Air Quality and Microbial Exposure
- Long-Term Effects of COVID-19
- Autophagy in Disease and Therapy
- Nicotinic Acetylcholine Receptors Study
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cannabis and Cannabinoid Research
- Health, Environment, Cognitive Aging
- Heme Oxygenase-1 and Carbon Monoxide
- Tea Polyphenols and Effects
- Phytochemicals and Antioxidant Activities
- Advanced Chemical Sensor Technologies
- Carcinogens and Genotoxicity Assessment
- Air Quality Monitoring and Forecasting
- COVID-19 and Mental Health
- Cancer, Stress, Anesthesia, and Immune Response
- SARS-CoV-2 and COVID-19 Research
- Asthma and respiratory diseases
- Environmental Toxicology and Ecotoxicology
- Genetics, Aging, and Longevity in Model Organisms
University of Rochester Medical Center
2018-2024
Purdue University West Lafayette
2024
University of Rochester
2019-2021
University of Nevada, Reno
2015-2017
Background: The respiratory health effects of inhalation exposure to e-cigarette flavoring chemicals are not well understood. We focused our study on the immuno-toxicological and oxidative stress by these two types human monocytic cell lines, Mono Mac 6 (MM6) U937. potential cause was assessed measuring production reactive oxygen species (ROS). hypothesized that used in e-juices/e-liquids induce an inflammatory response, cellular toxicity, ROS production. Methods: Two types, MM6 U937 were...
E-cigarette flavored pods are increasing in use among young adults. Although marketed as a safer alternative to conventional cigarettes, the health effects of e-cigarette unknown. We hypothesized that would cause oxidative stress, barrier dysfunction, and an inflammatory response monocytes lung epithelial cells. JUUL pod flavors (Fruit Medley, Virginia Tobacco, Cool Mint, Crème Brulee, Cucumber, Mango, Classic Menthol) similar (Just Mango-Strawberry Coconut Caffé Latte) were tested. These...
New emerging tobacco products, especially electronic cigarettes (E-Cig) or nicotine delivery systems (ENDS), have gained a huge popularity, particularly in younger populations. The lack of sufficient evidence-based health effect studies has promoted widespread use/abuse with the assumption that E-Cig ENDS and/or vaping products are safer and less toxic than conventional smoking. However, recent escalation acute lung injuries their associated fatalities among product users now brought...
Electronic cigarettes (e-cigs) were introduced as electronic nicotine delivery systems, and have become very popular in the USA globally. There is a paucity of data on systemic injury biomarkers vaping e-cig users that can be used noninvasive assessment vaping-associated lung injuries. We hypothesised characterisation inflammation, anti-inflammatory, oxidative stress, vascular lipid mediators, growth factors, extracellular matrix breakdown may provide information regarding toxicity users.We...
Abstract Electronic cigarette (e-cig) vaping is increasing rapidly in the United States, as e-cigs are considered less harmful than combustible cigarettes. However, limited research has been conducted to understand possible mechanisms that mediate toxicity and pulmonary health effects of e-cigs. We hypothesized sub-chronic e-cig exposure induces inflammatory response dysregulated repair/extracellular matrix (ECM) remodeling, which occur through α7 nicotinic acetylcholine receptor (nAChRα7)....
The Centers for Disease Control declared e-cigarette, or vaping, product use-associated lung injury (EVALI) a national outbreak due to the high incidence of emergency department admissions and deaths. We have identified chemical constituents in e-cig counterfeit cartridges compared these medical-grade CBD containing cartridges. Apart from vitamin E acetate (VEA) tetrahydrocannabinol (THC), other potential toxicants were including solvent-derived hydrocarbons, silicon conjugated compounds,...
Nicotine inhalation via electronic cigarettes (e-cigs) is an emerging concern. However, little known about the acute toxicity in lungs following of nicotine-containing e-cig aerosols. We hypothesized that exposure to aerosolized nicotine causes lung by eliciting inflammatory and dysregulated repair responses. Adult C57BL/6J mice were exposed 2 hours daily for 3 days aerosols containing propylene glycol (PG) with or without nicotine. Acute induced cell influx (neutrophils CD8a+ T...
Cigarette smoke (CS) is the main etiological factor in pathogenesis of emphysema/chronic obstructive pulmonary disease (COPD), which associated with abnormal epithelial-mesenchymal transition (EMT). Previously, we have shown an association among circadian rhythms, CS-induced lung inflammation, and nuclear heme receptor α (REV-ERBα), acting as antiinflammatory target both epithelial cells fibroblasts. We hypothesized that molecular clock REV-ERBα plays important role dysfunction EMT...
Abstract Cigarette smoke (CS) leads to increased oxidative stress, inflammation, and exaggerated senescence, which are involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). While role cellular senescence COPD is known, it not clear if removal senescent cells could alleviate symptoms. To test this, we used novel mouse model‐p16‐3MR, studied effect ganciclovir (GCV)‐mediated after CS (3 months) environmental tobacco (ETS) (6 exposure CS. Our results showed reversal...
Recently, there has been an outbreak of a condition named e-cigarette or vaping products-associated lung injury (EVALI). The primary components products include tetrahydrocannabinol (THC), vitamin E acetate (VEA) and medium-chain triglycerides (MCT), may be responsible for acute toxicity. Currently, little information is available on the physiological biological effects exposure to these products. We hypothesized that CBD/counterfeit vape cartridges their constituents (VEA MCT) induce...
Abstract Menthol and tobacco flavors are available for almost all products, including electronic cigarettes (e-cigs). These a mixture of chemicals with overlapping constituents. There no comparative toxicity studies these produced by different manufacturers. We hypothesized that acute exposure to menthol tobacco-flavored e-cig aerosols induces inflammatory, genotoxicity, metabolic responses in mouse lungs. compared two brands, A B, (PG/VG, menthol, tobacco) without nicotine their...
Emerging heated tobacco products (HTPs) were designed to reduce exposure toxicants from cigarette smoke (CS) by avoiding burning and instead heating tobacco. We studied the effects of short-term inhalation aerosols emitted HTP called IQOS, on lung damage immune-cell recruitment lungs in mice.
Flavoring chemicals in electronic nicotine delivery systems have been shown to cause cellular inflammation; meanwhile, the effects of fruit and tobacco flavors on lung inflammation by nose-only exposures mice are relatively unknown. We hypothesized that exposure flavored e-cigarettes would C57BL/6 J mice. The were exposed air, propylene glycol/vegetable glycerin, e-liquids: Apple, Cherry, Strawberry, Wintergreen, Smooth & Mild Tobacco, one hour per day for three days. Quantification...
Studies have shown that aerosols generated from flavored e-cigarettes contain Reactive Oxygen Species (ROS), promoting oxidative stress-induced damage within pulmonary cells. Our lab investigated the ROS content of e-cigarette vapor disposable (vape bars) with and without nicotine. Specifically, we analyzed vape bars belonging to multiple flavor categories (Tobacco, Minty Fruit, Fruity, Minty/Cool (Iced), Desserts, Drinks/Beverages) manufactured by various vendors different nicotine...
The use of emerging tobacco products, such as waterpipe or hookah and electronic cigarettes (e-cigs), has gained significant popularity are promoted safer alternatives to conventional cigarettes. Circadian systems internal biological oscillations that considered important regulators immune functions in mammals. Tobacco induced inflammatory lung diseases frequently exhibit time-of-day/night variation function symptom severity. We investigated the impact inhaled e-cig vapor smoke (WPS) on...
Electronic cigarette (e-cig) usage has risen dramatically worldwide over the past decade. While they are touted as a safe alternative to cigarettes, recent studies indicate that high levels of nicotine and flavoring chemicals present in e-cigs may still cause adverse health effects. We hypothesized an e-liquid containing mixture tobacco, coconut, vanilla, cookie flavors would induce senescence disrupt wound healing processes pulmonary fibroblasts. To test this hypothesis, we exposed...