A5080850966- Smoking Behavior and Cessation
- Air Quality and Health Impacts
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Nicotinic Acetylcholine Receptors Study
- Cancer, Stress, Anesthesia, and Immune Response
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Glycation End Products research
- Neuroendocrine regulation and behavior
- Sleep and Work-Related Fatigue
- Neuroscience and Neuropharmacology Research
- Asthma and respiratory diseases
- Eicosanoids and Hypertension Pharmacology
- Stress Responses and Cortisol
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
Cornell University
2022-2024
Weill Cornell Medicine
2022-2024
MIND Research Institute
2022-2024
New York Proton Center
2022
University of Rochester Medical Center
2019-2021
University of Rochester
2019-2020
Electronic cigarettes (e-cigs) were introduced as electronic nicotine delivery systems, and have become very popular in the USA globally. There is a paucity of data on systemic injury biomarkers vaping e-cig users that can be used noninvasive assessment vaping-associated lung injuries. We hypothesised characterisation inflammation, anti-inflammatory, oxidative stress, vascular lipid mediators, growth factors, extracellular matrix breakdown may provide information regarding toxicity users.We...
Abstract Electronic cigarette (e-cig) vaping is increasing rapidly in the United States, as e-cigs are considered less harmful than combustible cigarettes. However, limited research has been conducted to understand possible mechanisms that mediate toxicity and pulmonary health effects of e-cigs. We hypothesized sub-chronic e-cig exposure induces inflammatory response dysregulated repair/extracellular matrix (ECM) remodeling, which occur through α7 nicotinic acetylcholine receptor (nAChRα7)....
Nicotine inhalation via electronic cigarettes (e-cigs) is an emerging concern. However, little known about the acute toxicity in lungs following of nicotine-containing e-cig aerosols. We hypothesized that exposure to aerosolized nicotine causes lung by eliciting inflammatory and dysregulated repair responses. Adult C57BL/6J mice were exposed 2 hours daily for 3 days aerosols containing propylene glycol (PG) with or without nicotine. Acute induced cell influx (neutrophils CD8a+ T...
Background Waterpipe tobacco (WPT) smoking is associated with deleterious effects on cardio-pulmonary systems which may have adverse repercussions in pathophysiology and progression of chronic lung cardiovascular diseases. We compared the biomarkers systemic inflammation, lipid mediators, injury/repair oxidative stress between groups non-smokers (NS), exclusive WPT smokers (WPS), cigarette (CS) dual WPS CS (DS). Methods Two cohorts were recruited. Cohort I consisted (n=12), (n=26), DS (n=10)...
Astrocytic receptors influence cognitive function and can promote behavioral deficits in disease. These effects may vary based on variables such as biological sex, but it is not known if the of astrocytic are dependent sex. We leveraged vivo gene editing chemogenetics to examine roles spatial memory other processes. show that reductions metabotropic glutamate receptor 3 (mGluR3), main adults, impair females enhance males. Similarly, increases mGluR3 levels have sex-dependent females....
Abstract Electronic cigarette (e-cig) vaping is increasing rapidly in the United States, as e-cigs are considered less harmful than combustible cigarettes. However, limited research has been conducted to understand possible mechanism that mediate, toxicity and pulmonary health effects of e-cigs. We hypothesized sub-chronic e-cig exposure induces inflammatory response dysregulated repair/extracellular matrix (ECM) remodeling, which occur through α7 nicotinic acetylcholine receptor (nAChR α7)....
Abstract Cognitive processes and neurocognitive disorders are regulated by astrocytes have prominent sex differences. However, the contribution of to differences is not known. We leveraged astrocyte-targeted gene editing chemogenetics in adult mice reveal that astrocytic glutamate receptors other G protein-coupled (GPCRs) modulate hippocampus-dependent cognitive function a sexually dimorphic manner. In females, spatial memory was improved increasing metabotropic receptor 3 (mGluR3) or...
Abstract Electronic cigarette (e-cig) vaping is increasing rapidly in the United States, as e-cigs are considered less harmful than combustible cigarettes. However, limited research has conducted to understand mechanism of toxicological and pulmonary effects e-cigs. We hypothesized that sub-chronic exposure induced inflammatory response dysregulated repair/extracellular matrix (ECM) remodeling, which occur through α7 nicotinic acetylcholine receptor (nAChR α7). Adult wild-type (WT), nAChRα7...