A5053157930- Hematopoietic Stem Cell Transplantation
- Immunotoxicology and immune responses
- Carcinogens and Genotoxicity Assessment
- Drug-Induced Hepatotoxicity and Protection
- Parasites and Host Interactions
- Mycotoxins in Agriculture and Food
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Smoking Behavior and Cessation
- Toxic Organic Pollutants Impact
- Cancer-related molecular mechanisms research
- Tuberculosis Research and Epidemiology
- Acute Myeloid Leukemia Research
- Mycobacterium research and diagnosis
- Air Quality and Health Impacts
- Diagnosis and treatment of tuberculosis
- Research on Leishmaniasis Studies
- Animal Virus Infections Studies
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Neutropenia and Cancer Infections
- Epigenetics and DNA Methylation
University of Rochester
2008-2023
Indian Veterinary Research Institute
2021-2022
Patna Medical College and Hospital
2022
Lebanese University
2021
Shree Krishna Hospital
2021
University of Rochester Medical Center
2009-2020
Institute of Post Graduate Medical Education and Research
2020
Bastar University
2019
Government Medical College
2019
Nanaji Deshmukh Veterinary Science University
2014
Electronic cigarettes (e-cigs) were introduced as electronic nicotine delivery systems, and have become very popular in the USA globally. There is a paucity of data on systemic injury biomarkers vaping e-cig users that can be used noninvasive assessment vaping-associated lung injuries. We hypothesised characterisation inflammation, anti-inflammatory, oxidative stress, vascular lipid mediators, growth factors, extracellular matrix breakdown may provide information regarding toxicity users.We...
The aryl hydrocarbon receptor (AhR) belongs to the basic helix-loop-helix family of DNA-binding proteins that play a role in toxicity and carcinogenicity certain chemicals. most potent ligand AhR known is 2,3,7,8-tetracholorodibenzo-p-dioxin. We previously reported tetrachlorodibenzo-p-dioxin-induced alterations numbers function hematopoietic stem cells (HSCs). To better understand possible hematopoiesis, studies were undertaken young adult null-allele (KO) mice. These mice have enlarged...
Background Waterpipe tobacco (WPT) smoking is associated with deleterious effects on cardio-pulmonary systems which may have adverse repercussions in pathophysiology and progression of chronic lung cardiovascular diseases. We compared the biomarkers systemic inflammation, lipid mediators, injury/repair oxidative stress between groups non-smokers (NS), exclusive WPT smokers (WPS), cigarette (CS) dual WPS CS (DS). Methods Two cohorts were recruited. Cohort I consisted (n=12), (n=26), DS (n=10)...
The aryl hydrocarbon receptor (AhR) mediates the carcinogenicity of a family environmental contaminants, most potent being 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Increased incidence lymphoma and leukemia in humans is associated with TCDD exposure. Although AhR activation by has profound effects on immune system, precise cellular molecular mechanisms have yet to be determined. These studies tested hypothesis that alteration marrow populations following treatment mice due an effect...
Loss of immune function and increased hematopoietic disease are among the most clinically significant consequences aging. Hematopoietic stem cells (HSCs) from mice lacking aryl hydrocarbon receptor (AhR) have high rates cell division. Studies were designed to test hypothesis that aging AhR-null allele (AhR-KO) develop premature HSC exhaustion, changes leading hematological disease. Compared wild-type, AhR-KO showed a decreased survival rate, splenomegaly, circulating white blood cells,...
Abstract Background Electronic cigarettes (e-cigs) vaping, cigarette smoke, and waterpipe tobacco smoking are associated with various cardiopulmonary diseases. microRNAs present in higher concentration exosomes that play an important role physiological pathological functions. We hypothesized the non-coding RNAs transcript may serve as susceptibility to disease biomarkers by vaping. Methods Plasma exosomes/EVs from smokers, smokers dual (cigarette waterpipe) were characterized for their size,...
Summary Schistosomiasis mansoni, a tropical helminthic disease, is caused by disseminated worm eggs that induce CD4 + T‐cell mediated granulomatous inflammation and fibrosis. T suppressor cell activity has been proposed as one of the mechanisms active in down‐modulation murine disease during chronic stage (16–20 weeks infection). In recent years new category CD25 regulatory (Treg) lymphocyte identified maintains immune tolerance to self, also functions regulation parasite‐induced...
The aryl hydrocarbon receptor (AhR) is a transcription factor belonging to the Per-ARNT-Sim family of proteins. These proteins sense molecules and stimuli from cellular/tissue environment initiate signaling cascades elicit appropriate cellular responses. Recent literature reports suggest an important function AhR in hematopoietic stem cell (HSC) biology. However, molecular mechanisms by which regulates HSC functions are unknown. In previous studies, we others reported that treatment mice...
The present investigation was conducted to rule out canine distemper (CD) diseases in Indian wild felids (Asiatic lions, tigers, leopards, snow clouded leopard cats, jungle civet fishing cat, and jaguar). collected samples were screened for CD virus (CDV) by histopathology (HP), immunohistochemistry (IHC) reverse transcriptase-polymerase chain reaction (RT-PCR) targeting H gene N gene. HP IHC of suspected portrayed that 22 [11 6 3 1 cat] 129 (17.05%) positive CD. major pathological...
Schistosomiasis mansoni is characterized by hepatic granuloma formation. Endothelial cell activation within these granulomas may contribute to their development and increased vascularization in the periphery. The earliest event formation lodging of schistosome eggs presinusoidal capillaries. secrete factors that activate endothelial cells. This study investigated effects Schistosoma soluble egg antigen (SEA) on angiogenic processes:proliferation, tube formation, apoptosis human umbilical...
The effect of zinc treatment on immune function and resistance against infection tumor challenge was studied in mice. Swiss albino mice were treated with acetate (3 mg/kg body weight) one or two intraperitoneal injections. Various assays performed animals. Zinc to normal animals caused potentiation T-lymphocyte macrophage functions. also found increase host Candida albicans Semliki Forest virus infections. Increased endotoxin shock Ehrlich's ascites observed It can be stated from this study...
Arsenite treatment has been found to induce clinical remission in patients with acute promyelocytic leukemia. Although the potential therapeutic value of arsenite may lie triggering apoptosis, it not established that cytotoxicity is sole mechanism action. We have used a myelomonocytic leukemia cell line (U937) characterize concentration-dependent effects on growth, viability, and differentiation. multiple U937 cells. Low concentrations (i.e., < or = 1 microM) potentiate vitamin-D(3)-induced...
Summary Schistosomiasis mansoni is a tropical helminthic disease characterized by parasite egg‐induced granulomatous inflammation and cumulative fibrosis. Because fibrosis influenced the imbalance between degradative matrix metalloproteinases (MMPs) tissue inhibitors of (TIMPs), we analysed resorption fibrous MMP/TIMP expression in livers S. ‐infected praziquantel‐cured mice. Worm elimination significantly enhanced survival rate, ameliorated pathology reduced collagen I, III IV gene at 6 12...
Long non-coding RNAs (lncRNAs) are the varied set of transcripts that play a critical role in biological processes like gene regulation, transcription, post-transcriptional modification, and chromatin remodeling. Recent studies have reported presence lncRNAs exosomes involved regulating cell-to-cell communication lung pathologies including cancer, chronic obstructive pulmonary disease (COPD), asthma, idiopathic fibrosis (IPF). In this study, we compared lncRNA profiles plasma-derived amongst...
Aflatoxin (AF), the hepatocarcinogenic food contaminant produced by Aspergillus flavus group of fungi, is known to interact with various vital processes, including immune function. Effects long-term treatment three dose levels aflatoxin B1 (AFB1) on lymphoid cells weanling rats were studied. AFB1 caused a reduction in body weight gain, significantly (P less than 0.01) at 700 microgram level. There was also significant decrease spleen and thymus AFB1-treated animals comparison control....
The aryl hydrocarbon receptor (AHR) is a ligand‐activated transcription factor belonging to the Per‐Arnt‐Sim (PAS) family of proteins. AHR involved in hematopoietic stem cell (HSC) functions including self‐renewal, proliferation, quiescence, and differentiation. We hypothesize that impacts HSC by influencing genes have roles maintenance function this may occur through regulation bone marrow (BM) niche cells. examined BM cells harvested from 8‐week‐old null‐allele (KO) mice which exon 3 was...
In schistosomiasis mansoni, granulomatous inflammation and fibrotic resolution are the major pathogenetic factors. The outcome of fibrosis is influenced by deposition collagen degradation mediated matrix metalloproteinases (MMP). There a dearth data on expression MMP tissue inhibitors metalloproteinase (TIMP) during associated with schistosomiasis. this study, dynamics collagen, TIMP gene were analysed murine Schistosoma mansoni infection. Expression within liver genes coding for types I,...
The aryl hydrocarbon receptor (AHR) is a ligand activated bHLH transcription factor that belongs to the Per-Arnt-Sim (PAS) superfamily of proteins involved in mediating responses cellular environment regulating normal physiological and developmental pathways. AHR binds broad range naturally derived synthetic compounds, plays major role effects certain environmental chemicals. Although our understanding roles immune system evolving, there little known about its hematopoiesis hematopoietic...