Results of an observational, descriptive study quantifying topography characteristics twenty first generation electronic nicotine delivery system users in their natural environment for a one week observation period are presented. The quantifies inter-participant variation puffing between and the intra-participant each user observed during use environment. Puff presented include mean puff duration, flow rate volume participant, along with statistics quantity. Exposure including number vaping...

Electronic Nicotine Delivery Systems (ENDS) offer an alternate means to consume nicotine in a variety of flavored aerosols. Data are needed better understand the impact flavors on use behavior. A natural environment observational study was conducted experienced ENDS users measure effect e-liquid flavor topography and consumption The RIT wPUMTM monitor used record date time puff (flow rate, volume, duration) for every taken by N = 34 participants over course two weeks. All tobacco one week,...

Protocols for testing and reporting emissions of Harmful Potentially Constituents (HPHCs) from electronic cigarettes (e-cigs) are lacking. The premise this study is that multi-path relationships may be developed to describe interactions between product characteristics, use behavior develop appropriate protocols tobacco regulatory compliance testing.This proposes a framework consisting three component terms: HPHC mass concentration, ratio total particulate (TPM) concentration. informs...

Standardized topography protocols for testing cigarette emissions include the Federal Trade Commission/International Standard Organization (FTC/ISO), Massachusetts Department of Health (MDPH), and Canada (HC). Data are lacking how well these represent actual use behavior. This study aims to compare puff protocol standards measured in natural environments across a range brands. Current smokers between 18 65 years age were recruited. Each participant was provided with wPUM™ monitor instructed...

Background: Natural environment inhalation topography provides useful information for toxicant exposure, risk assessment and cardiopulmonary performance. Commercially available wearable respiratory monitors (WRMs), which are currently used to measure a variety of physiological parameters such as heart rate breathing frequency, can be leveraged obtain topography, yet little work has been done. This paper assesses the feasibility adapting these WRMs measuring topography. Methods: were compiled...

This study introduces and demonstrates a comprehensive, accurate, unbiased approach to robust quantitative comparison of electronic nicotine delivery systems (ENDS) appropriate for establishing substantial equivalence (or lack thereof) between inhaled products. The is demonstrated across family thirteen pen- pod-style ENDS Methods employed consist formulating emissions surface regression model, quantifying the empirical accuracy model as applied each product, evaluating relationships product...

Abstract Current in vitro emissions and exposure systems lack biomimicry, use unrealistic flow conditions, produce dose, provide inaccurate biomechanical cues to cell cultures, limiting ability correlate outcomes with vivo health effects. A biomimetic system capable of puffing aerosol clean air inhalation may empower researchers investigate complex questions related lung injury disease. (BAES), including an electronic cigarette adapter, oral cavity module (OCM), bifurcated chamber (BEC) was...

Laboratory emissions testing of electronic cigarettes continues to be a focus in the tobacco research community. In particular, inform policy regarding appropriate test protocols regulate manufacture, marketing and sale products. This study aims enhance current understanding way laboratory systems used generate topography profiles capture resultant from inhaled products may interact with device under test. A programmable emission system (vaping machine) is introduced characterized. The...

The popularity of electronic cigarettes in the United States and around world has led to a startling rise youth nicotine use. Juul® e-cigarette was introduced U.S. market 2015 had captured approximately 13% by 2017. Unlike many other contemporary cigarette companies, founders behind approached their product launch like traditional high-tech start-up company, not tobacco company. This article presents case study Juul’s corporate development history context US regulatory actions. objective...

Abstract Electronic nicotine delivery systems (ENDS) have been associated with a dramatic increase in youth becoming addicted to following decades-long decline cigarette smoking uptake. The United States Food and Drug Administration, Center for Tobacco Products (FDA/CTP) is responsible regulating devices consumable materials ENDS. State federal regulations regarding flavoring compounds ENDS liquids (e-liquids) may be circumvented when vendors market refillable reservoirs side-by-side...

In electronic nicotine delivery systems (ENDS), coil resistance is an important factor in the generation of heat energy used to change e-liquid into vapor. An accurate and unbiased method for testing vital understanding its effect on emissions reporting results that are comparable across different types brands ENDS measured laboratories. This study proposes a robust, measuring resistance. apparatus which mimics geometric configuration assembly reservoirs, coils power control units. The...

Background: Natural environment inhalation topography provides useful information for toxicant exposure, risk assessment and cardiopulmonary performance. Commercially available Wearable Respiratory Monitors (WRM), which are currently used to measure a variety of physiological parameters such as heart rate breathing frequency, can be leveraged obtain topography, yet little work has been done. This paper assesses the feasibility adapting these WRMs measuring topography. Methods: were compiled...

This work investigated the effects of manufacturing variations, including coil resistance and initial pod mass, on lifetime aerosol generation Vuse ALTO pods. Random samples pods were used until failure (where e-liquid was consumed, increased to high value indicating a break). Initial resistance, net mass ranged between 0.89 1.14 [Ω], 6.48 6.61 [g], 1.88 2.00 [g] respectively. Coil µ (mean) = 158, σ (standard deviation) 21.5 puffs. Total consumed 1.93, 0.035 [g]. TPM yield per puff all test...

Little is known about the natural use behavior of new and emerging tobacco products due to limited availability reliable puff topography monitors suitable for ambulatory deployment. An understanding needed assess health impact inform realistic standardized profiles emissions studies. The purpose this study validate four monitors: wPUM cigalike, vapepen, hookah, cigarette monitors.Each monitor was characterized validated range, accuracy, resolution flow rate, duration, volume, interpuff gap...

In Electronic Nicotine Delivery System (ENDS), coil resistance is an important factor in the generation of heat energy used to change e-liquid into vapor. An accurate and unbiased method for testing vital understanding its effect on emissions reporting results that are comparable across different types brands ENDS measured laboratories. This study proposes a robust, measuring resistance. apparatus which mimics geometric configuration assembly pods power control units. The demonstrated two...

This work investigated the effects of manufacturing variations including coil resistance, initial pod mass, and e-liquid color on lifetime aerosol generation Vuse ALTO pods. Random samples pods were used until failure (where was consumed, resistance increased to high value indicating a break). Initial net mass ranged between 0.89 1.14 [], 6.48 6.61 [g], 1.88 2.00 [g] respectively. Coil with light (mean) = 149, (standard deviation) 10.7 puffs while dark 185, 22.7 difference ~36 (p...

Lack of biomimicry in geometry and flow conditions emissions systems for analytical testing biological exposure has led to fundamental limitations, including a poor understanding dose delivered specific airway locations. This work characterizes mass distribution JUUL® brand e-cigarette Biomimetic Aerosol Exposure System (BAES).

Usage of waterpipes is growing in popularity around the world. Limited waterpipe natural environment topography data reduces ability research community to accurately assess emissions and user exposure toxicants. A portable ergonomic monitor was provided study participants use every time they smoked their own during a one-week monitoring period conjunction with choice shisha tobacco. Users demographic information logged product supplement electronic data. total 44 prospective were invited an...

: Limited research has been done to measure ambulatory respiratory behavior, in particular those associated with tobacco use, the natural environment due a lack of monitoring techniques. Respiratory topography parameters provide useful information for modeling particle deposition lung and assessing exposure risk health effects use. Commercially available Wearable Monitors (WRM), such as Hexoskin Smart Garment, have embedded sensors that chest motion may be adapted measuring volume.

Background: Limited research has been done to measure ambulatory respiratory behavior, in particular those associated with tobacco use, the natural environment due a lack of monitoring techniques. Respiratory topography parameters provide useful information for modelling particle deposition lung and assessing exposure risk health effects use. Commercially available Wearable Monitors (WRM), such as Hexoskin Smart Garment, have embedded sensors which chest motion may be adapted measuring...

The popularity of electronic cigarettes in the United States and around world has led to a startling rise youth nicotine use. Juul e-cigarette was introduced U.S. market 2015 had captured approximately 13% by 2017. Unlike many other contemporary cigarette companies, founders behind Juul® approached their product launch like traditional high-tech start-up company, not tobacco company. This article presents case study Juul’s corporate development history context US regulatory...

This study introduces and demonstrates a comprehensive, accurate, unbiased approach to robust quantitative comparison of Electronic Nicotine Delivery Systems (ENDS) appropriate for establishing substantial equivalence (or lack thereof) between tobacco products. The is demonstrated across family thirteen pen- pod-style ENDS Methods employed consist formulating emissions surface regression model, quantifying the empirical accuracy model as applied each product, evaluating relationships product...

Abstract Objective: This study characterizes three commercially available wearable respiratory monitors (WRMs): (1) Hexoskin Smart Garment, (2) Smartex WWS, and (3) Equivital EQ02 LifeMonitor, each with a unique chest motion sensor technology: inductance plethysmography, piezoresistor, strain gauge, respectively. WRMs comprise of body garment embedded sensors that measure ambulatory in real-time. Once calibrated, waveforms from can be converted to lung volume waveform, which is then used...