A5000631023- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Immune Response and Inflammation
- Neurogenetic and Muscular Disorders Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Prenatal Screening and Diagnostics
- Adipose Tissue and Metabolism
- Glioma Diagnosis and Treatment
- T-cell and B-cell Immunology
- MRI in cancer diagnosis
- Biochemical effects in animals
- CRISPR and Genetic Engineering
- Birth, Development, and Health
University of California, Davis
2016-2023
Dimethyl sulfoxide (DMSO) is a widely used solvent to dissolve hydrophobic substances for clinical uses and experimental in vivo purposes. While usually regarded safe, our prior studies suggest changes behavior following DMSO exposure. We therefore evaluated the effects of five-day, short-term exposure on postnatal infant rats (P6-10).DMSO was intraperitoneally injected five days at 0.2, 2.0, 4.0 ml/kg body mass. One cohort animals sacrificed 24 hr after analyze neurometabolic four brain...
Neuropilin-1 (Nrp1), a transmembrane protein expressed on CD4 + T cells, is mostly studied in the context of regulatory cell (Treg) function. More recently, there increasing evidence that Nrp1 also highly activated effector cells and increases these Nrp1-expressing correspond with immunopathology across several cell-dependent disease models. Thus, may be implicated identification function immunopathologic cells. downregulation one strongest transcriptional changes response to...
Zinc finger (ZF), transcription activator-like effectors (TALE), and CRISPR/Cas9 therapies to regulate gene expression are becoming viable strategies treat genetic disorders, although effective in vivo delivery systems for these proteins remain a major translational hurdle. We describe the use of mesenchymal stem/stromal cell (MSC)-based system secretion ZF protein (ZF-MSC) transgenic mouse models young rhesus monkeys. Secreted from ZF-MSC was detectable within hippocampus 1 week following...
Hydrogen sulfide (H2S) and other cysteine metabolites have been implicated in the growth spread of astrocytomas. The aim this study is to investigate cystathionine B-synthase (CBS; brain’s main H2S producing enzyme) expression astrocytomas its correlation with histopathological grade. Twenty two adult patients (14 M / 8 F), who underwent surgical resection for newly diagnosed were retrospectively reviewed CBS by immunohistochemistry (IHC). Patient age ranged from 26 77 years (mean 64 years)....
Neuropilin-1 (Nrp1), a transmembrane protein expressed on CD4