A5030797036- Smoking Behavior and Cessation
- Air Quality and Health Impacts
- Salivary Gland Disorders and Functions
- Fatty Acid Research and Health
- Consumer Attitudes and Food Labeling
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Nutritional Studies and Diet
- Biochemical Analysis and Sensing Techniques
- Noise Effects and Management
- Cannabis and Cannabinoid Research
- Indoor Air Quality and Microbial Exposure
- Obesity, Physical Activity, Diet
- Neuroscience of respiration and sleep
- Mesenchymal stem cell research
- Proteoglycans and glycosaminoglycans research
- Coffee research and impacts
- Diet, Metabolism, and Disease
- Natural Products and Biological Research
- Heavy Metal Exposure and Toxicity
- Coastal wetland ecosystem dynamics
- Global trade, sustainability, and social impact
- Neurological disorders and treatments
- Nutrition, Health and Food Behavior
- Marine and coastal plant biology
- Barrier Structure and Function Studies
Roswell Park Comprehensive Cancer Center
2015-2025
University at Buffalo, State University of New York
2013-2022
University of Utah
2014-2015
Délégation Paris 6
2004
King's College Hospital
1982
E-cigarettes or electronic nicotine delivery systems (ENDS) are designed to deliver nicotine-containing aerosol via inhalation. Little is known about the health effects of flavoured ENDS when inhaled.Aerosol from was generated using a smoking machine. Various types devices tank system prefilled with liquids different flavours, carrier, variable concentrations and modified battery output voltage were tested. A convenience sample commercial fluids flavour names tobacco, piña colada, menthol,...
E-cigarette or vaping product use-associated lung injury (EVALI) is a severe pulmonary illness associated with the use of e-cigarettes products that was officially identified and named in 2019. This American Thoracic Society workshop convened 2021 to identify prioritize research regulatory needs adequately respond EVALI outbreak prevent similar instances disease e-cigarette use. An interdisciplinary group 26 experts adult pediatric clinical care, public health, oversight, toxicology were for...
Background Heated tobacco product(s) (HTP), also called heat-not-burn products, are a re-emerging class of products that purport to reduce health risk compared with smoking combustible products. This study examined the potential toxic effects inhaling emissions from an HTP in comparison electronic and cigarettes. Methods Inhalation toxicity (IQOS; flavour), e-cigarette (MarkTen; flavour) cigarette (Marlboro Red) was vitro using air–liquid interface human bronchial epithelial cells (H292)....
Introduction In December 2022, California (CA) enforced a voter-approved regulation restricting the retail sale of flavoured tobacco products, including menthol cigarettes. Shortly after, new products emerged on market containing similar blue and green package colours yet with ‘non-menthol’ descriptors. Using chemical analyses, we measured content 15 other cooling chemicals in Californian cigarettes descriptors compared concentrations to ‘menthol’-labelled counterparts available New York...
<p>Biomarker exposures among participants from Canada who exclusively use NVPs in ITC JCH, stratified by self-reported puffs per day.</p>
<p>Biomarker exposures among participants who exclusively used CC in ITC JCH, stratified by country of residence.</p>
<div>AbstractBackground:<p>Comparisons of nicotine and toxicant exposures between people who use different alternative tobacco products remain underexplored.</p>Methods:<p>This cross-sectional, multicountry study analyzed urinary metabolites nicotine, tobacco-specific nitrosamines [4-methylnitrosamino-1-3-pyridyl-1-butanone (NNK)], volatile organic compounds (acrolein, acrylamide, acrylonitrile) among established users (<i>n</i> = 550) in Japan Canada....
<p>Associations between biomarkers of exposure and nicotine product use in multivariable linear regression models.</p>
Sjögren's syndrome (SS) is an autoimmune disorder characterized by chronic inflammation and destruction of salivary lacrimal glands, leading to dry mouth, eyes, the presence anti-nuclear antibodies. Despite modern advances, current therapies for SS have no permanent benefit. A potential treatment could involve use resolvins, which are highly potent endogenous lipid mediators that synthesized during resolution restore tissue homeostasis. Our previous studies indicate ALX/FPR2, receptor RvD1,...
E-liquids are commercially available and manufactured, however some users of e-cigarettes prefer to prepare them at home (Do-it-Yourself; DIY) using individual ingredients. To date there is a paucity research on how why make their own e-liquids.
The aim of this study was to examine puffing behavior and topography over 24 hours among regular electronic cigarette (e-cigarette) users.Twenty-four adult e-cigarette users (15 male) vaped their personal e-cigarettes ad-lib the course hours. Participants took each puff via calibrated CReSS pocket monitors. We analyzed: number puffs per day session, mean volume, flow rate, duration puff, interval between puffs.Over participants on average 156.2±10.3 puffs, clustered in 10.2±7.9 session with...
Emerging heated tobacco products (HTPs) were designed to reduce exposure toxicants from cigarette smoke (CS) by avoiding burning and instead heating tobacco. We studied the effects of short-term inhalation aerosols emitted HTP called IQOS, on lung damage immune-cell recruitment lungs in mice.
Salivary gland cell differentiation has been a recurring challenge for researchers as primary salivary cells show loss of phenotype in culture. Particularly, parotid marked decrease amylase expression, the tight junction organization and proper function. Previously, Matrigel used successfully an extracellular matrix; however, it is not practical vivo applications tumorigenic. An alternative method could rely on use fibrin hydrogel (FH), which extensively biomedical engineering ranging from...
Saliva plays a major role in maintaining oral health. Patients with salivary hypofunction exhibit difficulty chewing and swallowing foods, tooth decay, periodontal disease, microbial infections. At this time, treatments for hyposalivation are limited to medications (e.g., muscarinic receptor agonists: pilocarpine cevimeline) that induce saliva secretion from residual acinar cells as well artificial substitutes. Therefore, advancement of restorative is necessary improve the quality life these...
Resolvins are potent anti-inflammatory mediators derived from ω-3 fatty acids. Results our previous studies indicated that resolvin D1 (RvD1) blocks pro-inflammatory responses in salivary glands. Furthermore, RvD1 enhances epithelial integrity, demonstrating its potential use for the restoration of gland function Sjögren’s syndrome (SS). We investigated whether biosynthetic machinery ( e.g., cytosolic phospholipase A 2 , calcium-independent 12/15 and 5-lipoxygenase) is expressed mouse...
Heated Tobacco Products (HTPs) purport to reduce exposure tobacco-related toxicants compared combustible cigarettes. This cross-sectional study examined the content of nicotine, two humectants (propylene glycol (PG) and vegetable glycerin (VG)), four tobacco-specific nitrosamines (TSNAs: NNN, NNK, NAT, NAB) in tobacco filler a popular HTP brand (IQOS). Non-menthol menthol IQOS sticks were purchased from nine countries between 2017 2020 classified into versions (“Bold” “Light”) using Philip...
The discovery of resolvins has been a major breakthrough for understanding the processes involved in resolution inflammation. Resolvins belong to family novel lipid mediators that possess dual anti-inflammatory and pro-resolution actions. Specifically, they protect healthy tissue during immune-inflammatory responses infection or injury, thereby aiding inflammation promoting healing. One concerns modern medicine is management treatment oral diseases, as are related systemic outcomes impacting...
Background: The developing lung is uniquely susceptible and may be at increased risk of injury with exposure to e-cigarette constituents. We hypothesize that cellular toxicity airway vascular responses flavored refill solutions altered in the immature lung. Methods: Fetal, neonatal, adult ovine pulmonary artery smooth muscle cells (PASMC) were exposed popular nicotine-free (menthol, strawberry, tobacco, vanilla) unflavored solvents: propylene glycol (PG) or vegetable glycerin (VG). Viability...
Sjögren’s syndrome (SS) is a chronic inflammatory autoimmune disorder that causes secretory dysfunction of the salivary glands leading to dry mouth. Previous studies reported tight junction (TJ) proteins are down-regulated and lose polarity in human minor with SS, suggesting TJ structure compromised SS patients. In this paper, we utilized NOD/ShiLtJ mouse main goal evaluating model for future research. We found organization apical areas proximal distal lymphocytic infiltration remained...
POD electronic nicotine delivery systems (ENDS), often containing high concentrations of salts, have replaced MODs (ie, open/modifiable devices) as the most popular devices. The purpose this study was to compare device/liquid characteristics, use behavior, and exposure between MOD users.Data from initial visit a prospective observational exclusive ENDS users compared (n = 48) 37) users. Participants completed questionnaires on demographic patterns use, features. A urine sample collected test...
Freshly isolated salivary cells can be plated on an extracellular matrix, such as growth factor-reduced Matrigel (GFR-MG), to induce the formation of three-dimensional (3D) structures. Cells grown GFR-MG are able form round structures with hollow lumina, capable sustaining amylase expression. In contrast, plastic do not exhibit these features. Our recent studies have used mouse parotid gland (PG) cells, different matrices, a model for acinar formation. However, PG were respond secretory...