A5022620299- Clinical Nutrition and Gastroenterology
- Appendicitis Diagnosis and Management
- Intestinal Malrotation and Obstruction Disorders
- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Infant Nutrition and Health
- Minimally Invasive Surgical Techniques
- Hernia repair and management
- Neonatal Respiratory Health Research
- Gallbladder and Bile Duct Disorders
- Congenital Diaphragmatic Hernia Studies
- Child Nutrition and Feeding Issues
- Congenital Anomalies and Fetal Surgery
- Cardiac, Anesthesia and Surgical Outcomes
- Intraperitoneal and Appendiceal Malignancies
- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Abdominal Trauma and Injuries
- melanin and skin pigmentation
- Receptor Mechanisms and Signaling
- Infectious Diseases and Tuberculosis
- Congenital gastrointestinal and neural anomalies
- Streptococcal Infections and Treatments
- Adipose Tissue and Metabolism
Children's Hospital of Illinois
2016-2025
Illinois College
2016-2024
University of Illinois Chicago
2019-2024
OSF Saint Francis Medical Center
2016-2020
St Francis Medical Center
2019
St. Francis Medical Center
2019
University of Illinois Urbana-Champaign
2019
University of Alabama at Birmingham
2006-2013
Children's of Alabama
2012-2013
Background/Aims: Obesity is a common and rapidly growing health problem today. characterized by the increase of body fat an excess total and, in particular, visceral accumulation, considered to be risk factor for type 2 diabetes mellitus. To determine whether malfunction mesenteric adipose tissue plays important role diabetic related metabolic syndrome, this study, lipolysis gene expression subcutaneous, omental subjects were evaluated. Methods: Lipolysis real time PCR utilized adipocyte...
We compared color-flow duplex ultrasonographic scanning (CFD) to arteriography in 67 patients who sustained 75 penetrating injuries the extremities without obvious arterial injury. There were 72 negative and three (4.0%) positive CFD studies no failed attempts. With as “gold standard,” had a specificity of 99% sensitivity 50%, predictive values 66% 97%, an accuracy 96%. Small pseudoaneurysms missed axillary aberrant radial artery, genicular artery pseudoaneurysm was misread originating from...
Gastrostomy tube placement is among the most common gastrointestinal procedures performed in children. The U-stitch laparoscopic technique allows primary button and advantages of laparoscopy. purpose this study was to quantify completion rate occurrence complications a large single-institution experience.All gastrostomy between April 2000 May 2005 were reviewed. Complications that required operative treatment or hospital readmission classified as early (<90 days) late (> =90...
Macrophages are first seen in the fetal intestine at 11–12 wk and rapidly increase number during 12- to 22-wk period of gestation. The development macrophage populations precedes appearance lymphocytes neutrophils does not require presence dietary or microbial antigens. In this study, we investigated role chemerin, a recently discovered, relatively selective chemoattractant for macrophages, recruitment precursors intestine. Chemerin mRNA/protein expression was measured jejunoileal tissue...
Background: Opioid use has become an epidemic problem. There been a recent push toward strategies that minimize postoperative opioid use. Appendectomy is one of the most common procedures performed in pediatric population. Single-incision appendectomy through umbilicus safe and well-tolerated procedure. The aim this project was to review utilization children who have undergone single incision for perforated nonperforated appendicitis. Methods: A retrospective review, approved by University...
Objective: In a murine model of intestinal injury, we hypothesized that Toll-like receptor 2 (TLR2), recognition molecule for commensal bacteria, plays an important role in the development mucosal immunity and is protective against ischemia/reperfusion injury via modulation both innate acquired immunity. Design: Interventional laboratory study. Setting: Academic medical research center. Subjects: Four-week-old C57BL/6 wild-type (n = 12) TLR2-deficient mice (TLR2−/−) 12). Interventions:...
The melanocortin-2 receptor (MC2R), also known as the adrenocorticotropic hormone (ACTH) receptor, plays an important role in regulating and maintaining adrenocortical function, specifically steroidogenesis. Mutations of human MC2R (hMC2R) gene have been identified humans with familial glucocorticoid deficiency; however, molecular basis responsible for hMC2R ligand binding signaling remains unclear. In this study, both truncated ACTH peptides site-directed mutagenesis studies were used to...
Melanocortin 4 receptor (MC4R) plays an important role in the regulation of food intake and body weight. To determine molecular basis human MC4R (hMC4R) responsible for alpha-melanocortin-stimulating hormone (alpha-MSH) binding, this study, we utilized both domain exchange site-directed mutagenesis studies to investigate determinants hMC4R alpha-MSH binding signaling. is a potent agonist at but not hMC2R. Cassette substitutions second, third, fourth, fifth, sixth transmembrane regions (TM)...
Melanocortin-3 receptor (MC3R), primarily expressed in the hypothalamus, plays an important role regulation of energy homeostasis. MC3R-deficient (MC3R-/-) mice demonstrate increased fat mass, higher feeding efficiency, hyperleptinaemia, and mild hyperinsulinism. At least one specific mutation MC3R has been identified to be associated with human obesity. Functional analysis this altered (I183N) indicated that completely abolishes agonist-mediated activation. However, molecular determinants...
Despite being pioneered by gynecologists, single-incision endosurgery has not been widely reported for the treatment of ovarian and adnexal pathology in neonates, children, adolescents. We describe our initial experience using pediatric (SIPES) these indications discuss advantages drawbacks.All children who underwent SIPES with a preoperative diagnosis or were included study. Data on age, operative time, complications, length hospital stay, outcomes collected.From January 2010 until 2012, 19...
Introduction: Single-incision pediatric endosurgery (SIPES) has gained popularity for ablative procedures such as appendectomy in many surgical centers. This study evaluates the outcome of SIPES treatment appendicitis our institution. Patients and Methods: After Institutional Review Board approval was obtained, data were prospectively collected on all patients undergoing hospital from March 2009 through October 2011. The techniques, operative times, complications, conversion rates, outcomes...
Virtual reality modeling (VRM) is a 3-dimensional simulation created from patient-specific 2-dimensional (2D) imaging. VRM creates more accurate representation of the patient anatomy and can improve anatomical perception. We surveyed surgeons on their operative plan in complex pediatric oncology cases based review 2D imaging subsequently after VRM. hypothesized that confidence level would increase with use virtual may change plan.
Single-incision pediatric endosurgery (SIPES) is gaining popularity. The aim of this study was to review the authors' experience with SIPES splenectomy and compare it conventional laparoscopic splenectomy.After institutional board approval, data on in children were collected prospectively. group compared a control patients who retrospectively identified as having undergone during same time period.Sixteen underwent splenectomy. Ages ranged from 1 15 years, median 7 weights between 10 70 kg,...