A5059925670- Head and Neck Cancer Studies
- Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Surgical Oncology
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Pancreatic function and diabetes
- Neuroendocrine Tumor Research Advances
- Signaling Pathways in Disease
- Neuroblastoma Research and Treatments
- Cancer Research and Treatments
- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Wound Healing and Treatments
- Radiopharmaceutical Chemistry and Applications
- CAR-T cell therapy research
- HER2/EGFR in Cancer Research
- Glioma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Brain Metastases and Treatment
- Toxin Mechanisms and Immunotoxins
- Neurofibromatosis and Schwannoma Cases
- Ear and Head Tumors
- Reconstructive Surgery and Microvascular Techniques
University of Alabama at Birmingham
2011-2024
ImaginAb (United States)
2024
St. Vincent's Birmingham
2015
University of Alabama
2012
Positive margins dominate clinical outcomes after surgical resections in most solid cancer types, including head and neck squamous cell carcinoma. Unfortunately, surgeons remove the same manner they have for a century with complete dependence on subjective tissue changes to identify operating room. To effect change, we hypothesize that EGFR can be targeted safe specific real-time localization of cancer.A dose escalation study cetuximab conjugated IRDye800 was performed patients (n = 12)...
Abstract Purpose: Comprehensive cervical lymphadenectomy can be associated with significant morbidity and poor quality of life. This study evaluated the sensitivity specificity cetuximab-IRDye800CW to identify metastatic disease in patients head neck cancer. Experimental Design: Consenting scheduled for curative resection were enrolled a clinical trial evaluate safety cetuximab-IRDye800CW. Patients (n = 12) received escalating doses drug. Where indicated, accompanied primary tumor resection,...
Abstract Anti-EGFR (epidermal growth factor receptor) antibody based treatment strategies have been successfully implemented in head and neck squamous cell carcinoma (HNSCC). Unfortunately, predicting an accurate reliable therapeutic response remains a challenge on per-patient basis. Although significant efforts invested understanding EGFR-mediated changes signaling related to efficacy, the delivery histological localization (peri-)tumoral compartments of antibody-based therapeutics human...
Macrophages are first seen in the fetal intestine at 11–12 wk and rapidly increase number during 12- to 22-wk period of gestation. The development macrophage populations precedes appearance lymphocytes neutrophils does not require presence dietary or microbial antigens. In this study, we investigated role chemerin, a recently discovered, relatively selective chemoattractant for macrophages, recruitment precursors intestine. Chemerin mRNA/protein expression was measured jejunoileal tissue...
The standard treatment for glioblastoma multiforme (GBM) remains maximal safe surgical resection. Here, we evaluated the ability of a systemically administered antibody–dye probe conjugate (cetuximab-IRDye 800CW) to provide sufficient fluorescent contrast resection disease in both subcutaneous and orthotopic animal models GBM. Multiple luciferase-positive GBM cell lines (D-54MG, U-87MG, U-251MG; n = 5) were implanted mouse flank tumors fluorescently imaged daily using closed-field...
Rationale: Novel immune-activating therapeutics for the treatment of glioblastoma multiforme (GBM) have shown potential tumor regression and increased survival over standard therapies.However, immunotherapy efficacy remains inconsistent with response assessment being complicated by early treatment-induced apparent radiological progression slow downstream effects.This inability to determine immunotherapeutic benefit results in a drastically decreased window alternative, potentially more...
Abstract Objectives/Hypothesis: Head and neck squamous cell carcinoma (HNSCC) is a complex disease process involving interactions with carcinoma‐associated fibroblasts endothelial cells. We further investigated these relationships by suppressing stromal growth through the inhibition of fibroblast factor receptor (FGFR). Study Design: Preclinical investigation. Methods: HNSCC lines (FADU, OSC19, Cal27, SCC1, SCC5, SCC22A), (HS27), cells (human umbilical vascular cell) were cultured...
Abstract Epidermal growth factor receptor (EGFR), human epidermal 2 (HER2), and hypoxia are associated with radioresistance. The goal of this study is to the synergy anti-HER2, trastuzumab, anti-EGFR, cetuximab, characterize tumor microenvironment components that may lead increased radiation sensitivity dual anti-HER2/EGFR therapy in head neck squamous cell carcinoma (HNSCC). Positron emission tomography (PET) imaging ([ 89 Zr]-panitumumab [ Zr]-pertuzumab) was used EGFR HER2 HNSCC line...
Abstract Purpose: The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has continually increased during the past several decades. Using transoral robotic surgery (TORS) significantly improves functional outcomes relative to open for OPSCC. However, TORS limits tactile feedback, which is often most important element cancer surgery. Fluorescence-guided (FGS) strategies aid surgeon assessment malignancy resection are in various phases clinical research but exhibit greatest potential...
Head and neck squamous cell carcinoma tumors (HNSCC) contain a dense fibrous stroma which is known to promote tumor growth, although the mechanism of stroma-mediated growth remains unclear. As dysplastic mucosal epithelium progresses cancer, there incremental overexpression extracellular matrix metalloprotease inducer (EMMPRIN) associated with metastasis. Here, we present evidence that gain EMMPRIN expression allows be less dependent on fibroblasts by modulating fibroblast factor receptor-2...
Inadequate delivery of therapeutics into tumors has been suggested as a reason for poor response. We hypothesize that bevacizumab, an antibody to vascular endothelial growth factor (VEGF), can improve cetuximab uptake in squamous cell carcinoma tumors. Athymic nude mice were implanted with OSC19 and SCC1 human cancer lines subcutaneous flank model. Mice imaged daily 14 days after intravenous tail vein injections the following groups: IgG-IRDye800 (Control), cetuximab-IRDye800 (CTX800 Only),...
Abstract Maximal safe resection of malignant tissue is associated with improved progression-free survival and better response to radiation chemotherapy for patients glioblastoma (GBM). 5-Aminolevulinic acid (5-ALA) the current FDA-approved standard intraoperative brain tumor visualization. Unfortunately, autofluorescence in diffuse areas high fluorescence dense tissues significantly limit discrimination at margins. This study first compare 5-ALA an investigational new drug,...
Purpose To assess the early therapeutic effects of anti‐EMMPRIN (extracellular matrix metalloprotease inducer) antibody with/without cisplatin or X‐ray radiation in head and neck cancer mouse models using dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI). Materials Methods Mice bearing SCC1 (or OSC19) tumor xenografts were treated with antibody, radiation, cisplatin, plus radiation) for a week (n = 4–5 per group). DCE‐MRI was carried out on 9.4T small animal MR scanner days 0,...
Advanced cutaneous squamous cell carcinoma (SCC) is an uncommon and aggressive malignancy. As a result, there limited understanding of its biology pathogenesis. CD147 epidermal growth factor receptor (EGFR) have been identified as oncologically important targets, but their relationship remains undefined in SCC.Multiple SCC lines (Colo-16, SRB-1, SRB-12), were treated vitro with range chimeric anti-CD147 monoclonal antibody (mAb) (0, 50, 100, 200 µg/mL) or transfected small interfering RNA...
Abstract Introduction: Alabama (AL) is tied for third-highest incidence rate and has second-highest death of cervical cancer as 2020. Globally, the fourth-highest among cancers in women; 90% deaths from 2020 occurred low- middle-income (LMIC) countries. Inhibitor differentiation/DNA binding 1 (Id1) expression correlates with tumorigenesis, clinical grade/stage, aggressiveness cancer. Thus, Id1 could be exploited novel screening approaches that aim to improve survival rates LMIC clinically...
<p>Supplementary Figure S2: Additional characterization of bipolar forceps instrument and normal tissue fluorescence signals without the tumor in view.</p>
<p>Supplementary Video S1: Late-resection intraoperative brightfield and robot fluorescence views of representative OPSCC cases.</p>