A5077614613- Head and Neck Cancer Studies
- Palliative Care and End-of-Life Issues
- Cancer Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Radiomics and Machine Learning in Medical Imaging
- Photodynamic Therapy Research Studies
- Childhood Cancer Survivors' Quality of Life
- Ethics in medical practice
- Oral Health Pathology and Treatment
- Patient Dignity and Privacy
- Cancer survivorship and care
- Oral health in cancer treatment
- Proteoglycans and glycosaminoglycans research
- Cardiac, Anesthesia and Surgical Outcomes
- Salivary Gland Tumors Diagnosis and Treatment
- Innovations in Medical Education
- Family and Patient Care in Intensive Care Units
- Tumors and Oncological Cases
- Empathy and Medical Education
- COVID-19 and healthcare impacts
- Connective tissue disorders research
- Patient-Provider Communication in Healthcare
- Ethics and Legal Issues in Pediatric Healthcare
- Fibroblast Growth Factor Research
- Photoacoustic and Ultrasonic Imaging
University of Alabama at Birmingham
2019-2025
O'Neal Steel (United States)
2025
University of Alabama
2020-2024
Research for Equity And Community Health Trust
2024
Realistic Education in Action Coalition to Foster Health
2024
Cleveland Clinic
2024
University of Kansas
2021-2023
Creighton University
2023
O'Neal Comprehensive Cancer Center
2021
University of Colorado Denver
2021
Palliative care has evolved to be an integral part of comprehensive cancer with the goal early intervention improve quality life and patient outcomes. The NCCN Guidelines for Care provide recommendations help primary oncology team promote best possible throughout illness trajectory each cancer. Panel meets annually evaluate update based on panel members' clinical expertise emerging scientific data. These Insights summarize panel's recent discussions highlights updates importance fostering...
Importance Numerous studies show that early palliative care improves quality of life and other key outcomes in patients with advanced cancer their caregivers, although most lack access to this evidence-based model care. Objective To evaluate whether delivering via secure video vs in-person visits has an equivalent effect on non–small cell lung (NSCLC). Design, Setting, Participants Randomized, multisite, comparative effectiveness trial from June 14, 2018, May 4, 2023, at 22 US centers among...
Abstract Background Cancer cachexia negatively impacts cancer‐related treatment options, quality of life, morbidity, and mortality, yet no established therapies exist. We investigated the anabolic properties testosterone to limit loss body mass in late stage cancer patients undergoing standard care treatment. Methods A randomized, double‐blind, placebo‐controlled phase II clinical trial was undertaken assess potential therapeutic role adjunct with squamous cell carcinoma cervix or head neck...
ABSTRACT Background Literature about ocular toxicity after head and neck cancer (HNC) treatment is scarce. This study aimed to describe visual function symptoms among HNC patients. Methods The used a cross‐sectional design. Two surveys, National Eye Institute Visual Functioning Questionnaire (NEI‐VFQ) an Ocular Symptom Scale, were sent participants via e‐mail. Descriptive statistics the sample in vision change non‐vision groups. Chi‐square t ‐tests compare Results Of 485 patients emailed,...
Objective The purpose of this study was to find a correlation between closure technique in pharyngeal and outcomes both pharyngocutaneous fistula post‐laryngectomy stricture after laryngectomy. Study Design Retrospective Chart Review. Methods We retrospectively reviewed total 151 patients over 20‐year period from January 1994 December 2013 who underwent primary reconstruction laryngectomy specifically looking at the relation pharyngo‐cutaneous ( PCF ) postoperatively. Patients were excluded...
Abstract Reductions in skeletal muscle function occur during the course of healthy aging as well with bed rest or diverse diseases such cancer, muscular dystrophy, and heart failure. However, there are no accepted pharmacologic therapies to improve impaired function. Nitric oxide may influence through effects on excitation‐contraction coupling, myofibrillar function, perfusion, metabolism. Here we show that augmentation nitric oxide‐cyclic guanosine monophosphate signaling by short‐term...
Cell migration in blood flow is mediated by engagement of specialized adhesion molecules that function under hemodynamic shear conditions, and many the effectors these adhesive interactions, such as selectins their ligands, are well defined. However, contrast, our knowledge operant lymphatic conditions incomplete. Among human malignancies, head neck squamous cell cancer displays a marked predilection for locoregional lymph node metastasis. Based on this distinct tropism, we hypothesized...
This American Head and Neck Society (AHNS) consensus statement focuses on evidence-based comprehensive pain management practices for thyroid parathyroid surgery. Overutilization of opioids postoperative is a major contributing factor to the opioid addiction epidemic however guidelines after routine head neck endocrine procedures are lacking.An expert panel was convened from membership AHNS, its Endocrine Surgical Section, ThyCa. An extensive literature review performed, recommendations...
The ongoing worldwide pandemic due to COVID-19 has forced drastic changes on the daily lives of global population. This is most notable within health care sector. current paper outlines response head and neck oncologic surgery (HNS) division our academic otolaryngology department in state Alabama.
Abstract Background Patients living in rural areas experience a variety of unmet needs that result healthcare disparities. The triple threat geography, racial inequities, and older age hinders access to high-quality palliative care (PC) for significant proportion Americans. Rural patients with life-limiting illness are at risk not receiving appropriate due limited specialty workforce, long distances treatment centers, PC clinical expertise. Although culture strongly influences people’s...
Depth-resolved label-free optical imaging by the method of multiphoton autofluorescence microscopy (MPAM) may offer new ways to examine cellular and extracellular atypia associated with epithelial squamous cell carcinoma (SCC). MPAM was evaluated for its ability identify microstructural in head neck tissues from resected discarded tumor tissue. Three-dimensional image volumes were obtained floor mouth, tongue, larynx, then processed histology. micrographs qualitative metrics quantitative...
Optical spectroscopy has proven to be a powerful technique for studying neoplastic transformation in epithelial tissue. Since specific intra-layer precancerous changes originate the stratified layers of oral mucosa, layer-resolved analysis will likely improve both our understanding mechanism premalignant transformation, and clinical diagnostic outcomes. However, native fluorescence signal linear typically originates from multi-layered focal volume. In this study, nonlinear was exploited vivo...
Early neoplastic features in oral epithelial dysplasia are first evident at the basal epithelium positioned epithelial-connective tissue interface (ECTI), separating from underlying lamina propria. The ECTI undergoes significant deformation early neoplasia due to focal expansion and proteolytic remodeling of propria, but few studies have examined these changes. In present study, we quantitated alterations topography using vivo volumetric multiphoton autofluorescence microscopy second...
Abstract Purpose: The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has continually increased during the past several decades. Using transoral robotic surgery (TORS) significantly improves functional outcomes relative to open for OPSCC. However, TORS limits tactile feedback, which is often most important element cancer surgery. Fluorescence-guided (FGS) strategies aid surgeon assessment malignancy resection are in various phases clinical research but exhibit greatest potential...
The epithelial-connective tissue interface (ECTI) plays an integral role in epithelial neoplasia, including oral squamous cell carcinoma (OSCC). This undergoes significant alterations due to hyperproliferating epithelium that supports the transformation of normal precancers and cancer. We present a method based on nonlinear optical microscopy directly assess ECTI quantify dysplastic using hamster model for carcinogenesis. Neoplastic non-neoplastic mucosa were imaged in-vivo by both...
Debates regarding clinical ethicists' scope of practice are not novel and will continue to evolve. Rapid changes in healthcare delivery, outcomes, expectations have necessitated flexibility roles whereby hospital-based ethicists expected be woven into the institutional fabric a way that did exist more traditional relationships. In this article we discuss three emerging roles: ethicist embedded interdisciplinary team, with an expanded educational mandate, as therapeutic presence patient care...
The objective of this study was to evaluate the nonlinear optical microscopy techniques multiphoton autofluorescence (MPAM) and second harmonic generation (SHGM) for noninvasive imaging oral epithelial carcinogenesis. In vivo performed in a hamster model carcinogenesis characterize morphometric alterations during neoplastic transformation. Data is presented showing morphometry collagen density precancerous phase