A5007454087- Muscle metabolism and nutrition
- Muscle Physiology and Disorders
- Traumatic Brain Injury Research
- Ion Transport and Channel Regulation
- Gut microbiota and health
- Nutrition and Health in Aging
- Cancer survivorship and care
- Traumatic Brain Injury and Neurovascular Disturbances
- Drug Transport and Resistance Mechanisms
- Cardiovascular and exercise physiology
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Long-Term Effects of COVID-19
- Spaceflight effects on biology
- Childhood Cancer Survivors' Quality of Life
- COVID-19 and Mental Health
- Optimism, Hope, and Well-being
- Amino Acid Enzymes and Metabolism
- Diet and metabolism studies
- Hormonal and reproductive studies
- Pancreatic function and diabetes
- Folate and B Vitamins Research
- Restraint-Related Deaths
- Tryptophan and brain disorders
- Chemotherapy-induced cardiotoxicity and mitigation
- Congenital Diaphragmatic Hernia Studies
The University of Texas Medical Branch at Galveston
2010-2024
Texas A&M University
2019-2022
Galveston College
2010
GTx (United States)
2010
Michigan State University
2006
Patients with chronic traumatic brain injury (TBI) requiring long-term, permanent care suffer a myriad of clinical symptoms (i.e., impaired cognition, fatigue, and other conditions) that persist for years beyond the acute injury. In addition to these comorbid symptoms, TBI patients exhibit altered amino acid hormonal profiles distinct cytokine patterns suggesting inflammation. This metabolic link suggests role gut-brain axis in TBI. Thus, we utilized two-site trial investigate comorbidities...
Abstract Background Cancer cachexia negatively impacts cancer‐related treatment options, quality of life, morbidity, and mortality, yet no established therapies exist. We investigated the anabolic properties testosterone to limit loss body mass in late stage cancer patients undergoing standard care treatment. Methods A randomized, double‐blind, placebo‐controlled phase II clinical trial was undertaken assess potential therapeutic role adjunct with squamous cell carcinoma cervix or head neck...
Introduction Patients who suffer a traumatic brain injury (TBI) often experience chronic and sometimes debilitating sequelae. Recent reports have illustrated both acute long-term dysbiosis of the gastrointestinal microbiome with significant alterations in composition predicted functional consequences. Methods Working participants from past research, metagenomic stability TBI- associated fecal (FMB) was evaluated by custom qPCR array comparing sample 2015 to one collected 2020....
The kidney contains two Na<sup>+</sup>/glucose cotransporters, called SGLT2 and SGLT1, arranged in series along the length of proximal tubule. low-affinity transporter, SGLT2, is responsible for reabsorption most glucose kidney. There recent interest as a target treatment type II diabetes using selective inhibitors based on structure phenylglucoside, phlorizin (phloretin-2′-β-glucoside). In this study, we examined inhibition α-methyl-d-glucopyranose transport by new candidate drug,...
Pituitary dysfunction with reduced growth hormone (GH) secretion is common in patients following traumatic brain injury (TBI), and these often develop chronic symptoms including fatigue altered cognition. We examined 18 subjects a history of mild TBI, fatigue, insufficient GH secretion. Subjects received replacement year-long, double-blind, placebo-controlled, crossover study, were assessed for changes physical performance, body composition, resting energy expenditure, sleep, mood,...
Background Following traumatic brain injury (TBI) some patients develop lingering comorbid symptoms of fatigue and cognitive impairment. The mild impairment self-reported by is often not detected with neurocognitive tests making it difficult to determine how common severe these are in individuals a history TBI. This study was conducted the relative prevalence Methods Fatigue Altered Cognition Scale (FACs) digital questionnaire used assess Adults aged 18–70 were digitally recruited for online...
The combination of increasing blood flow and amino acid (AA) availability provides an anabolic stimulus to the skeletal muscle healthy young adults by optimizing both AA delivery utilization. However, aging is associated with a blunted response stimuli may involve impairments in endothelial function. We investigated whether age-related differences exist protein AAs between younger (30 ± 2 yr) older (67 when macrovascular microvascular leg were similarly increased nitric oxide (NO) donor,...
Standard-of-care (SOC) cancer treatments are primarily aimed at reducing size and progression of a tumor. There is need for successful supplemental anabolic therapies to combat cachexia in addition these SOC treatment modalities. Anabolic interventions, including testosterone amino acid supplements, may be beneficial and/or reversing muscle wasting patient populations.A 48-year-old Caucasian female with recurrent cervical was scheduled receive three 21-day cycles cisplatin topetecan...
Abstract Reductions in skeletal muscle function occur during the course of healthy aging as well with bed rest or diverse diseases such cancer, muscular dystrophy, and heart failure. However, there are no accepted pharmacologic therapies to improve impaired function. Nitric oxide may influence through effects on excitation‐contraction coupling, myofibrillar function, perfusion, metabolism. Here we show that augmentation nitric oxide‐cyclic guanosine monophosphate signaling by short‐term...
Abstract Following SARS‐CoV‐2 infection, some patients develop lingering neurologic symptoms of post‐acute sequelae COVID‐19 (PASC) that commonly include fatigue and “brain fog.” PASC are also linked with reduced growth hormone (GH) secretion, but GH treatment has not been tested to relieve symptoms. We enrolled 13 adults peak stimulated secretion less than 10 ng/mL (glucagon stimulation) in a pilot study receive 9 months daily injections an additional 3 off‐treatment assessment. compared at...
The Na+/dicarboxylate co-transporter, NaDC-1, from the kidney and small intestine, transports three sodium ions together with one divalent anion substrate, such as succinate2-. A previous study (Pajor, A. M. (2001) J. Biol. Chem. 276, 29961-29968), identified four amino acids, Ser-478, Ala-480, Ala-481, Thr-482, near extracellular end of transmembrane helix (TM) 9 that are likely to form part permeation pathway transporter. All cysteine-substituted mutants were sensitive inhibition by...
Prolonged confinement to head-down bed rest (HDBR) results in musculoskeletal losses similar those observed during long-duration space flight. Exercise countermeasures by themselves have not completely prevented the deleterious muscle mass or function HDBR flight.The objective was investigate safety and efficacy of intermittent, low-dose testosterone treatment conjunction with NASA exercise (SPRINT) 70 d 6° HDBR.Healthy men (35 ± 8 yr) were randomized into one three groups that remained...
Individuals with a history of traumatic brain injury (TBI) are at increased risk for number disorders, including Alzheimer's disease, Parkinson's and chronic encephalopathy. However, mediators the long-term morbidity uncertain. We conducted multi-site, prospective trial in TBI patients (∼18 years post-TBI) living 24-h care environments local controls without head injury. Inability to give informed consent was exclusionary participation. A total 41 individuals (17 moderate-severe TBI, 24...
The Na<sup>+</sup>/dicarboxylate cotransporter NaDC1 absorbs citric acid cycle intermediates from the lumen of small intestine and kidney proximal tubule. No effective inhibitor has been identified yet, although previous studies showed that nonsteroidal anti-inflammatory drug, flufenamate, inhibits human (h) with an IC<sub>50</sub> value 2 mM. In present study, we have tested compounds related in structure to all anthranilic derivatives, as potential inhibitors hNaDC1. We found...
Introduction Long-term head-down bed rest (HDBR) results in musculoskeletal losses similar to those observed during long-term space flight. Agents such as testosterone, addition regular exercise, are effective countermeasures for reducing loss of skeletal muscle mass and function. Objective We investigated the proteome healthy men response long term HDBR alone (CON) with exercise (PEX) or plus testosterone (TEX) countermeasures. Method Biopsies were performed on vastus lateralis before (pre)...
Debilitating symptoms of fatigue and accompanying “brain fog” are observed among patients with various chronic health conditions. Unfortunately, an efficient psychometrically sound instrument to assess these co-occurring is unavailable. Here, we report the development initial psychometric properties Fatigue Altered Cognition Scale (the FACs), a measure self-reported central brain fog. Traumatic injury (TBI) was chosen model develop FACs due research team expertise established links between...
Adjunct testosterone therapy improves lean body mass, quality of life, and physical activity in patients with advanced cancers; however, the effects on cardiac morphology function are unknown. Accordingly, as an ancillary analysis a randomized, placebo-controlled trial investigating efficacy supplementation composition men women cancers, we explored whether could prevent or reverse left ventricular (LV) atrophy dysfunction. Men recently diagnosed late stage (≥IIB) recurrent head neck...
Introduction: Both cancer and associated therapies (CAT; including chemotherapy or concurrent chemoradiation) disrupt cellular metabolism throughout the body, regulation of skeletal muscle mass function. Adjunct testosterone therapy during standard care chemoradiation modulates CAT-induced dysregulation protects lean body CAT. However, extent to which proteome is altered under these therapeutic conditions unknown. Objective: We probed patients as an ancillary analysis following a randomized,...