A5054078305- Palliative Care and End-of-Life Issues
- Cancer survivorship and care
- Parathyroid Disorders and Treatments
- Childhood Cancer Survivors' Quality of Life
- Economic and Financial Impacts of Cancer
- Breast Cancer Treatment Studies
- Genetic Syndromes and Imprinting
- Medical Imaging and Pathology Studies
- Colorectal Cancer Treatments and Studies
- Thyroid Cancer Diagnosis and Treatment
- Frailty in Older Adults
- Pancreatic and Hepatic Oncology Research
- COVID-19 and Mental Health
- Family Support in Illness
- Cancer Genomics and Diagnostics
- COVID-19 and healthcare impacts
- Epigenetics and DNA Methylation
- Health Systems, Economic Evaluations, Quality of Life
- Histone Deacetylase Inhibitors Research
- Family and Disability Support Research
- HER2/EGFR in Cancer Research
- Geriatric Care and Nursing Homes
- Patient Dignity and Privacy
- Breast Lesions and Carcinomas
- Cancer Cells and Metastasis
University of Utah
2015-2024
Huntsman Cancer Institute
2015-2024
University of Wisconsin–Madison
2023-2024
Community Living
2024
University of Iowa Hospitals and Clinics
2017-2023
Memorial Sloan Kettering Cancer Center
2023
University of Iowa
2016-2023
University of Glasgow
2018-2023
Medical College of Wisconsin
2022
University of Minnesota
2022
Models that recapitulate the complexity of human tumors are urgently needed to develop more effective cancer therapies. We report a bank patient-derived xenografts (PDXs) and matched organoid cultures from represent greatest unmet need: endocrine-resistant, treatment-refractory metastatic breast cancers. leverage PDXs PDX-derived organoids (PDxO) for drug screening is feasible cost-effective with in vivo validation. Moreover, we demonstrate feasibility using these models precision oncology...
The NCCN Guidelines for Palliative Care provide interdisciplinary recommendations on palliative care patients with cancer. These Insights summarize and context the updated guidelines regarding hospice end-of-life (EOL) care. Updates 2017 include revisions to restructuring of algorithms that address important EOL concerns. were revised clearer guidance oncologists as they cancer who are approaching transition Recommendations interventions reassessment based estimated life expectancy...
Palliative care has evolved to be an integral part of comprehensive cancer with the goal early intervention improve quality life and patient outcomes. The NCCN Guidelines for Care provide recommendations help primary oncology team promote best possible throughout illness trajectory each cancer. Panel meets annually evaluate update based on panel members' clinical expertise emerging scientific data. These Insights summarize panel's recent discussions highlights updates importance fostering...
The NCCN Guidelines for Palliative Care provide interdisciplinary recommendations on palliative care patients with cancer. are intended to guidance the primary oncology team integration of into oncology. Panel's seek ensure that each patient experiences best quality life possible throughout illness trajectory. Accordingly, outline practices screening, assessment, interventions, reassessment, and after-death care.
Patients with cancer experience high rates of morbidity and unplanned health care utilization may benefit from new models care. We evaluated an adult oncology hospital at home program's rate hospitalizations costs secondarily, emergency department (ED) use, length stays, intensive unit (ICU) admissions during the 30 days after enrollment.We conducted a prospective, nonrandomized, real-world cohort comparison 367 hospitalized patients cancer-169 consecutively admitted discharge to Huntsman...
Research indicates that dispositional mindfulness is associated with positive psychological functioning. Although this disposition has been linked beneficial outcomes in the broader mental health literature, less known about cancer survivors and how it may be indices of physical relevant to survivorship.We conducted a multivariate path analysis data from heterogeneous sample patients (N = 97) test Mindfulness-to-Meaning Theory, an extended process model emotion regulation linking...
Although sentinel lymph node biopsy is now the primary method of axillary staging and therapeutic for patients with limited nodal disease, dissection (ALND) still necessary in groups where has not been proven to be accurate maintain local control those a heavy tumor burden. Additionally, newer approaches systemic therapy tailored risk level sometimes necessitate knowledge number involved nodes which can only obtained ALND. Ongoing trials will address whether there are additional...
Assessing risk of recurrence for nonmetastatic triple-negative breast cancer (TNBC) is a key determinant therapeutic strategy. The best predictor failure to achieve pathologic complete response after preoperative chemotherapy, but it imperfectly correlates with the definitive end points relapse-free and overall survival (OS). inability accurately predict has led increasingly toxic treatment regimens patients early-stage TNBC. Better assays are needed tailor aggressive therapy who need avoid...
Capecitabine is used to treat advanced breast and gastrointestinal malignancies. A single case of encephalopathy three cases peripheral neuropathy are the only neurotoxicities reported. The authors report five additional capecitabine-induced multifocal leukoencephalopathy.
Abstract In melanoma metastasis, the role of AP-2α transcription factor, which is encoded by TFAP2A, controversial as some findings have suggested tumor suppressor activity while other studies shown high TFAP2A expression in node-positive associated with poor prognosis. Here we demonstrate that facilitates metastasis through transcriptional activation genes within E2F pathway including EZH2. A BioID screen found interacts members nucleosome remodeling and deacetylase (NuRD) complex. Loss...
Introduction: The primary aims of this Stage I pilot randomized controlled trial were to establish the feasibility integrating exercise and nutrition counseling with Mindfulness-Oriented Recovery Enhancement (MORE), a novel intervention that unites training in mindfulness, reappraisal, savoring skills target mechanisms underpinning appetitive dysregulation pathogenic process contributes obesity among cancer survivors; identify potential therapeutic MORE intervention; obtain effect sizes...
Abstract Model systems that recapitulate the complexity of human tumors and reality variable treatment responses are urgently needed to better understand cancer biology develop more effective therapies. Here we report development characterization a large bank patient-derived xenografts (PDX) matched organoid cultures from represent some greatest unmet needs in breast research treatment. These include endocrine-resistant, treatment-refractory, metastatic cancers and, cases, multiple tumor...
Toxic epidermal necrolysis (TEN) and Stevens–Johnson Syndrome (SJS) are rare yet severe exfoliative skin disorders. The authors examined the efficacy of predictive models for their use as prognostic indicators in pediatric SJS or TEN. Over a 15-year period, 41 patients ≤18 years age were identified reviewed. Predictive compared retrospectively to observed mortality population included: SCORTEN (Score Epidermal Necrolysis), Pediatric Index Mortality 2, Risk III-24, Abbreviated Burn Severity...
The COVID-19 pandemic has disrupted many facets of life. We evaluated pandemic-related health care experiences, prevention behaviors and measures, behaviors, psychosocial outcomes among rural urban cancer patients.Among 1,472 adult patients, who visited Huntsman Cancer Institute in the past 4 years completed a survey (August-September 2020), we assessed impact on medical appointments, prevention/health factors, stratified by urbanicity.Mean age was 61 years, with 52% female, 97% non-Hispanic...
Abstract Background Psilocybin-assisted psychotherapy has demonstrated significant promise as a treatment for depression, anxiety, and existential distress associated with serious medical illness generally been employed on an individual basis, which presents challenges scaling resource availability. There are also compelling theoretical reasons to suggest that group-based formats-if utilized in thoughtful fashion-might offer unique or enhanced therapeutic benefits certain conditions...
This prognostic study performed external validation of a machine learning model to predict 6-month mortality among patients with advanced solid tumors.
To design an interface to support communication of machine learning (ML)-based prognosis for patients with advanced solid tumors, incorporating oncologists' needs and feedback throughout design.
Hospice aides are integral to the delivery of home hospice care and play an essential role in effective communication collaboration interdisciplinary team. Despite their critical role, little is known about aides' perceptions providing services. This qualitative study explores perspectives work, relationships with patients, families team members, contributions end-of-life care. Two focus groups (N = 13), 16 hours observation in-home caregiving were conducted. Focus group data inductively...