A5039071000- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Advanced biosensing and bioanalysis techniques
- Advanced Biosensing Techniques and Applications
- Phagocytosis and Immune Regulation
- RNA Interference and Gene Delivery
- Lipid Membrane Structure and Behavior
- Cellular transport and secretion
- Estrogen and related hormone effects
- Nanoparticle-Based Drug Delivery
- Lysosomal Storage Disorders Research
- Erythrocyte Function and Pathophysiology
- Radiopharmaceutical Chemistry and Applications
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Cell Adhesion Molecules Research
- PI3K/AKT/mTOR signaling in cancer
- Cancer Immunotherapy and Biomarkers
- Computational Drug Discovery Methods
- Glycosylation and Glycoproteins Research
- Pancreatic and Hepatic Oncology Research
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
University of Utah
2021-2025
Shaanxi University of Chinese Medicine
2024
Huntsman Cancer Institute
2021-2024
Jackson Laboratory
2022
University of Cincinnati Medical Center
2004-2020
University of Cincinnati
2005-2017
Cincinnati Children's Hospital Medical Center
2004-2016
Chinese Academy of Medical Sciences & Peking Union Medical College
1998-2000
Chinese Academy of Sciences
1998
Harbin Medical University
1998
Despite the fact that continuity of morphology fossil specimens modern humans found in China has repeatedly challenged Out-of-Africa hypothesis, Chinese populations are underrepresented genetic studies. Genetic profiles 28 sampled supported distinction between southern and northern populations, while latter biphyletic. Linguistic boundaries often transgressed across language families studied, reflecting substantial gene flow populations. Nevertheless, evidence does not support an independent...
Models that recapitulate the complexity of human tumors are urgently needed to develop more effective cancer therapies. We report a bank patient-derived xenografts (PDXs) and matched organoid cultures from represent greatest unmet need: endocrine-resistant, treatment-refractory metastatic breast cancers. leverage PDXs PDX-derived organoids (PDxO) for drug screening is feasible cost-effective with in vivo validation. Moreover, we demonstrate feasibility using these models precision oncology...
// Subrahmanya D. Vallabhapurapu 1 , Víctor M. Blanco Mahaboob K. Sulaiman Swarajya Lakshmi Zhengtao Chu 1,2 Robert S. Franco and Xiaoyang Qi Division of Hematology Oncology, Department Internal Medicine, University Cincinnati College Cincinnati, Ohio, USA 2 Divison Human Genetics, Correspondence to: Qi, email: Keywords : phosphatidylserine, surface exposure, cancer cell biomarker, flippase, calcium Received August 27, 2015 Accepted September 09, Published October Abstract Viable cells...
Abstract Development of candidate cancer treatments is a resource-intensive process, with the research community continuing to investigate options beyond static genomic characterization. Toward this goal, we have established landscapes 536 patient-derived xenograft (PDX) models across 25 types, together mutation, copy number, fusion, transcriptomic profiles, and NCI-MATCH arms. Compared human tumors, PDXs typically higher purity fit dynamic driver events molecular properties via multiple...
// Víctor M. Blanco 1 , Zhengtao Chu 1,2 Subrahmanya D. Vallabhapurapu Mahaboob K. Sulaiman Ady Kendler 3 Olivier Rixe 4 Ronald E. Warnick 5 Robert S. Franco and Xiaoyang Qi Division of Hematology Oncology, Department Internal Medicine, University Cincinnati College Cincinnati, Ohio 2 Human Genetics, Pediatrics, Children's Hospital Medical Center, Pathology Laboratory Hematology/Oncology, Georgia Regents University, GRU Cancer Augusta, Neurosurgery, Brain Tumor Mayfield Clinic,...
Assessing risk of recurrence for nonmetastatic triple-negative breast cancer (TNBC) is a key determinant therapeutic strategy. The best predictor failure to achieve pathologic complete response after preoperative chemotherapy, but it imperfectly correlates with the definitive end points relapse-free and overall survival (OS). inability accurately predict has led increasingly toxic treatment regimens patients early-stage TNBC. Better assays are needed tailor aggressive therapy who need avoid...
Abstract In the United States, more than 280,000 women are diagnosed with breast cancer every year, 90% of deaths caused by metastatic disease. 20-30% patients will develop metastasis, despite receiving state-of-the-art therapies. Once metastases detected, disease becomes incurable. Developing therapeutic interventions that eliminate metastasis represents a significant challenge in field, as tumors evolve and resistance, ultimately undermining tumor’s response to therapy. Underlying this...
Abstract Purpose: Saposin C is a multifunctional protein known to activate lysosomal enzymes and induce membrane fusion in an acidic environment. Excessive accumulation of lipid-coupled saposin lysosomes cytotoxic. Because neoplasms generate microenvironment, caused by leakage hypoxia, we hypothesized that may be effective anticancer agent. We investigated the antitumor efficacy systemic biodistribution nanovesicles comprised coupled with dioleoylphosphatidylserine preclinical cancer models....
Saposin C-dioleoylphosphatidylserine (SapC-DOPS) nanovesicles are a nanotherapeutic which effectively target and destroy cancer cells. Here, we explore the systemic use of SapC-DOPS in several models brain cancer, including glioblastoma multiforme (GBM), molecular mechanism behind its tumor-selective targeting specificity. Using two validated spontaneous tumor models, demonstrate ability to selectively cross blood–brain barrier (BBTB) tumors vivo reveal be contingent on exposure anionic...
Alternatively spliced tissue factor (asTF) promotes neovascularization and monocyte recruitment via integrin ligation. While asTF mRNA has been detected in some pancreatic ductal adenocarcinoma (PDAC) cell lines increased expression can promote PDAC growth a subcutaneous model, the of protein bona fide lesions and/or its role metastatic spread are yet to be ascertained. We here report that is abundant lesional stromal compartments five studied types carcinoma including PDAC. Analysis 29...
Only a small number of promising drugs target pancreatic cancer, which is the fourth leading cause cancer deaths with 5-year survival less than 5%. Our goal to develop new biotherapeutic agent in lysosomal protein (saposin C, SapC) and phospholipid (dioleoylphosphatidylserine, DOPS) are assembled into nanovesicles (SapC-DOPS) for treating cancer. A distinguishing feature SapC-DOPS their high affinity phosphatidylserine (PS) rich microdomains, abnormally exposed on membrane surface human...
Enzyme replacement therapy (ERT) can positively affect the visceral manifestations of lysosomal storage diseases (LSDs). However, exclusion intravenous ERT agents from central nervous system (CNS) prevents direct therapeutic effects.Using a neuronopathic Gaucher disease (nGD) mouse model, CNS-ERT was created using systemic, non-invasive, and CNS-selective delivery based on nanovesicles saposin C (SapC) dioleoylphosphatidylserine (DOPS) to deliver CNS cells tissues corrective, functional acid...
We created the PDX Network (PDXNet) portal (https://portal.pdxnetwork.org/) to centralize access National Cancer Institute-funded PDXNet consortium resources, facilitate collaboration among researchers and make these data easily available for research. The includes sections analysis results, metrics activities, processing protocols training materials data. Currently, contains model information resources from 334 new models across 33 cancer types. Tissue samples of were deposited in NCI's...
// Harold W. Davis 1 , Subrahmanya D. Vallabhapurapu Zhengtao Chu Swarajya L. Robert S. Franco Michelle Mierzwa 2 William Kassing Barrett and Xiaoyang Qi 1, 3 Division of Hematology/Oncology, Translational Research Laboratory, Department Internal Medicine, University Cincinnati College Cincinnati, OH, USA Radiation Oncology, Human Genetics, Pediatrics, Children's Hospital Medical Center, Correspondence to: Qi, email: xiaoyang.qi@uc.edu Keywords: radiotherapy-induced resistance; surface...
Abstract Model systems that recapitulate the complexity of human tumors and reality variable treatment responses are urgently needed to better understand cancer biology develop more effective therapies. Here we report development characterization a large bank patient-derived xenografts (PDX) matched organoid cultures from represent some greatest unmet needs in breast research treatment. These include endocrine-resistant, treatment-refractory, metastatic cancers and, cases, multiple tumor...
SapC-DOPS is a novel nanotherapeutic that has been shown to target and induce cell death in variety of cancers, including glioblastoma (GBM). GBM primary brain tumor known frequently demonstrate resistance apoptosis-inducing therapeutics. Here we explore the mode action for GBM, treatment being developed by Bexion Pharmaceuticals clinical testing patients. was observed lysosomal dysfunction cells characterized decreased glycosylation LAMP1 altered proteolytic processing cathepsin D...
Abstract Lung cancer is the deadliest type of for both men and women. In this study, we evaluate in vitro vivo efficacy a biotherapeutic agent composed lysosomal protein (Saposin C, SapC) phospholipid (dioleoylphosphatidylserine, DOPS), which can be assembled into nanovesicles (SapC–DOPS) with selective antitumor activity. SapC–DOPS targets phosphatidylserine, an anionic preferentially exposed surface cells tumor-associated vasculature. Because binding SapC to phosphatidylserine favored at...
Squamous cell carcinoma (SCC) and melanoma are malignant human cancers of the skin with an annual mortality that exceeds 10,000 cases every year in USA alone. In this study, lysosomal protein saposin C (SapC) phospholipid dioloylphosphatidylserine (DOPS) were assembled into cancer-selective nanovesicles (SapC-DOPS) successfully tested using several vitro vivo cancer models. Using MTT assay measures percentage death, SapC-DOPS cytotoxic effect on three tumor lines (squamous carcinoma,...
// Víctor M. Blanco 1 , Zhengtao Chu 1, 2 Kathleen LaSance 3 Brian D. Gray 4 Koon Yan Pak Therese Rider 5 Kenneth Greis Xiaoyang Qi Division of Hematology-Oncology, Department Internal Medicine, University Cincinnati College Cincinnati, Ohio 45267, USA Human Genetics, Pediatrics, Children's Hospital Medical Center, 45229, Radiology, Molecular Targeting Technologies, Inc., West Chester, Pennsylvania 19380, Cancer Biology, Correspondence to: Qi, email: xiaoyang.qi@uc.edu Keywords:...
// Dusten Unruh 1 , Betül Ünlü 2 Clayton S. Lewis Xiaoyang Qi Zhengtao Chu Robert Sturm Ryan Keil Syed A. Ahmad Timofey Sovershaev 3 Mariette Adam 4 Patrick Van Dreden Barry J. Woodhams 5 Divya Ramchandani 6 Georg F. Weber Janusz W. Rak 7 Alisa Wolberg 8 Nigel Mackman Henri H. Versteeg Vladimir Y. Bogdanov College of Medicine, University Cincinnati, OH, USA Leiden Medical Center, Leiden, The Netherlands Arctic Norway, Tromsø, Norway Diagnostica Stago R & D, Gennevilliers, France Haemacon...