A5062536269- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- Gastric Cancer Management and Outcomes
- Inflammatory mediators and NSAID effects
- Cancer, Lipids, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Screening and Detection
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Gastrointestinal Tumor Research and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Platelet Disorders and Treatments
- HER2/EGFR in Cancer Research
- Gastrointestinal disorders and treatments
- Estrogen and related hormone effects
- Cell Adhesion Molecules Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Eicosanoids and Hypertension Pharmacology
- PI3K/AKT/mTOR signaling in cancer
The University of Texas MD Anderson Cancer Center
2016-2025
City Of Hope National Medical Center
2019
City of Hope
2019
Springer Nature (Germany)
2017
Centre for Cancer Biology
1999-2015
University of Chicago
2010
Jeonbuk National University
2010
Dartmouth–Hitchcock Medical Center
2009
National Cancer Centre Singapore
2009
Texas A&M University
2009
Background Colorectal cancer (CRC) incidence is increasing in adults younger than 50 years. This study evaluated clinical and molecular features to identify those unique early‐onset CRC that differentiate these patients from years old or older. Methods Baseline characteristics were according the onset age with 3 independent cohorts. A fourth cohort was used describe impact of on consensus subtype (CMS) prevalence. Results retrospective review more 36,000 showed likely have microsatellite...
Abstract Purpose: Colorectal cancers are classified as right/left-sided based on whether they occur before/after the splenic flexure, with established differences in molecular subtypes and outcomes. However, it is unclear if this division optimal precise tumor location provides further information. Experimental Design: In 1,876 patients colorectal cancer, we compared mutation prevalence overall survival (OS) according to side location. Consensus subtype (CMS) was a separate cohort of 608...
High circulating neutrophil-lymphocyte ratio (NLR) appears to be prognostic in metastatic colorectal cancer (mCRC). We investigated the relationship of NLR with cytokines and molecular alterations. performed retrospective analyses on multiple cohorts CRC patients (metastatic untreated (n=166), refractory (n=161), hepatectomy (n=198), stage 2/3 (n=274), molecularly screened (n=342)). (ratio absolute neutrophil-to-lymphocyte counts peripheral blood) was defined as NLR>5. Plasma were evaluated...
HER2 amplification has been implicated in resistance to therapy with anti-epidermal growth factor receptor antibodies (anti-EGFRabs) metastatic colorectal cancer (mCRC). The purpose of the study was validate predictive impact mCRC.We analyzed patients RAS/BRAF wild-type mCRC across two distinct cohorts. In cohort 1 (n = 98), tested tumor tissue using dual situ hybridization (HER2 amplification: HER2/CEP17 ratio, 2.0 or greater). Cohort 2 70) included 16 and 54 nonamplified controls...
Prostaglandins exert a profound influence over the adhesive, migratory, and invasive behavior of cells during development progression cancer. Cyclooxygenase-2 (COX-2) microsomal prostaglandin E(2) synthase-1 (mPGES-1) are upregulated in inflammation This results production (PGE(2)), which binds to activates G-protein-coupled E(1-4) receptors (EP(1-4)). Selectively targeting COX-2/mPGES-1/PGE(2)/EP(1-4) axis pathway can reduce adhesion, migration, invasion, angiogenesis. Once stimulated by...
Non-coding RNAs have been drawing increasing attention in recent years as functional data suggest that they play important roles key cellular processes. N-BLR is a primate-specific long non-coding RNA modulates the epithelial-to-mesenchymal transition, facilitates cell migration, and increases colorectal cancer invasion. We performed multivariate analyses of from two independent cohorts patients show abundance associated with tumor stage, invasion potential, overall patient survival. Through...
Abstract Development of candidate cancer treatments is a resource-intensive process, with the research community continuing to investigate options beyond static genomic characterization. Toward this goal, we have established landscapes 536 patient-derived xenograft (PDX) models across 25 types, together mutation, copy number, fusion, transcriptomic profiles, and NCI-MATCH arms. Compared human tumors, PDXs typically higher purity fit dynamic driver events molecular properties via multiple...
KRAS and NRAS mutations occur in 45% of colorectal cancers, with combined MAPK pathway CDK4/6 inhibition identified as a potential therapeutic strategy. In the current study, this combinatorial treatment approach was evaluated co-clinical trial patient-derived xenografts (PDX), safety established clinical binimetinib palbociclib patients metastatic cancer RAS mutations. Across 18 PDX models undergoing dual MEK CDK4/6, 60% tumors regressed, meeting primary endpoint. Prolonged duration...
Although overexpression of the low-affinity p75 neurotrophin receptor (p75NTR) is frequently associated with advanced stages human melanoma progression, functional significance this finding unknown. We examined whether degree cell surface expression p75NTR in variants determines their extent invasion stimulated by nerve growth factor (NGF). Treatment MeWo cells or a metastatic spontaneous wheat germ agglutinin-resistant variant subline (70W) 2.5S NGF resulted dose-dependent enhancement...
3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) inhibitors, commonly known as statins, may possess cancer preventive and therapeutic properties. Statins are effective suppressors of cholesterol synthesis with a well-established risk-benefit ratio in cardiovascular disease prevention. Mechanistically, targeting HMGCR activity primarily influences biosynthesis prenylation signaling proteins. Pravastatin is hydrophilic statin that selectively taken up by sodium-independent organic anion...
3517 Background: HER2 amplification (HERamp), seen in 5% of KRAS wildtype (WT) metastatic colorectal cancers (mCRC), is associated with resistance to anti-epidermal growth factor receptor antibodies (antiEGFRabs). The purpose this study was validate the predictive impact HERamp mCRC. Methods: We performed systematic analyses RAS and BRAF WT mCRC patients (pts) across 2 distinct cohorts. tested cohort 1 (N = 97) using immunohistochemistry dual in-situ hybridization (HERamp: HER2/CEP17 ≥ 2.2)....