A5100752230- Cancer-related molecular mechanisms research
- Plant Molecular Biology Research
- Plant Reproductive Biology
- MicroRNA in disease regulation
- Retinoids in leukemia and cellular processes
- RNA modifications and cancer
- Circular RNAs in diseases
- RNA Research and Splicing
- Plant nutrient uptake and metabolism
- Plant Disease Resistance and Genetics
- Polysaccharides and Plant Cell Walls
- RNA and protein synthesis mechanisms
- Bioactive Compounds and Antitumor Agents
- Plant Stress Responses and Tolerance
- Phytochemistry and biological activity of medicinal plants
- Grey System Theory Applications
- Plant Gene Expression Analysis
- Plant tissue culture and regeneration
- Carbon dioxide utilization in catalysis
- Catalysis for Biomass Conversion
- Genomics, phytochemicals, and oxidative stress
- Plant Surface Properties and Treatments
- Plant biochemistry and biosynthesis
- Cancer Research and Treatments
- COVID-19 epidemiological studies
Lanzhou University
2012-2024
Guangdong Province Women and Children Hospital
2023-2024
Thomas Jefferson University
2011-2024
Yunnan Normal University
2018-2024
Peking University Shenzhen Hospital
2021-2023
BGI Group (China)
2015-2022
BGI Genomics
2019-2022
Sanya University
2022
South China Normal University
2021
Chongqing Public Health Medical Center
2007-2021
Human blood platelets are essential to maintaining normal hemostasis, and platelet dysfunction often causes bleeding or thrombosis. Estimates of genome-wide RNA expression using microarrays have provided insights the transcriptome but were limited by number known transcripts. The goal this effort was deep-sequence from leukocyte-depleted capture complex profile all expressed From each four healthy individuals we generated long (≥40 nucleotides) profiles total ribosomal-RNA depleted...
MicroRNAs (miRNAs) are endogenous, small noncoding RNAs that play important roles in various cellular functions and tumor development. Recent studies have indicated miR-21 is one of the miRNAs associated with growth metastasis, but role molecular mechanism regulating angiogenesis remain to be elucidated. In this study, was overexpressed by transfecting pre-miR-21 into human prostate cancer cells assayed using chicken chorioallantoic membrane (CAM). We found overexpression DU145 increased...
Significance MicroRNAs (miRNAs) are small ∼22-nt RNAs that important regulators of posttranscriptional gene expression. Since their initial discovery, they have been shown to be involved in many cellular processes, and misexpression is associated with disease etiology. Currently, nearly 2,800 human miRNAs annotated public repositories. A key question miRNA research how harbored by the genome. To answer this question, we examined 1,323 short RNA sequence samples identified 3,707 novel miRNAs,...
The Arabidopsis thaliana somatic embryogenesis receptor kinases (SERKs) consist of five members, SERK1 to SERK5, the leucine-rich repeat receptor-like kinase subfamily II (LRR-RLK II). SERK3 was named BRI1-Associated Receptor Kinase 1 (BAK1) due its direct interaction with brassinosteroid (BR) BRI1 in vivo, while SERK4 has also been designated as BAK1-Like (BKK1) for functionally redundant role BAK1. Here we provide genetic and biochemical evidence demonstrate that SERKs are absolutely...
Here we describe our study of miRNA isoforms (isomiRs) in breast cancer (BRCA) and normal data sets from the Cancer Genome Atlas (TCGA) repository. We report that full isomiR profiles, both known novel human-specific loci, are particularly rich information can distinguish tumor tissue much better than archetype miRNAs. IsomiR expression is also dependent on patient's race, exemplified by miR-183-5p, several isomiRs which upregulated triple negative BRCA white but not black women....
// Aristeidis G. Telonis 1 , Phillipe Loher Shozo Honda Yi Jing Juan Palazzo 2 Yohei Kirino and Isidore Rigoutsos Computational Medicine Center, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA Department of Pathology Anatomy Cell Biology, Correspondence to: Rigoutsos, email: Keywords : tRNA fragment, human genome, nuclear tRNA, mitochondrial Argonaute Received June 10, 2015 Accepted 20, Published July 06, Abstract We analyzed transcriptomic data from 452...
Hello MTO: Efficient and environmentally responsible conversion methods are needed to deal with excess glycerol production. The catalytic of allyl alcohol under neat conditions is catalyzed by methyltrioxorhenium (MTO). yields volatile products selectivity for very good. Mechanistic studies reveal transfer hydrogenation via bifunctional catalysis. Detailed facts importance specialist readers published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset....
Cholesterol metabolism disorder in hepatocytes predicts a higher risk of metabolic syndrome (MetS). Long noncoding RNAs (lncRNAs) have emerged as critical players cellular cholesterol metabolism, but their functions are not systematically clarified. Here, we identified novel lncRNA named lnc‐HC negatively regulating within through physical interaction with hnRNPA2B1. By further binding to the target messenger RNA Cyp7a1 or Abca1 , ‐hnRNPA2B1 complex decreases expressions two genes that...
Abstract Regulatory T (Treg) cells are essential for maintaining immune homeostasis and tolerance, but the mechanisms regulating stability function of Treg have not been fully elucidated. Here we show SUMO-specific protease 3 (SENP3) is a pivotal regulator that functions by controlling SUMOylation nuclear localization BACH2. cell-specific deletion Senp3 results in cell activation, autoimmune symptoms enhanced antitumor responses. SENP3-mediated BACH2 deSUMOylation prevents export BACH2,...
Non-coding RNAs have been drawing increasing attention in recent years as functional data suggest that they play important roles key cellular processes. N-BLR is a primate-specific long non-coding RNA modulates the epithelial-to-mesenchymal transition, facilitates cell migration, and increases colorectal cancer invasion. We performed multivariate analyses of from two independent cohorts patients show abundance associated with tumor stage, invasion potential, overall patient survival. Through...
Appropriate cell division and differentiation ensure normal anther development in angiosperms. BARELY ANY MERISTEM 1/2 (BAM1/2) RECEPTOR-LIKE PROTEIN KINASE2 (RPK2), two groups of leucine-rich repeat receptor-like protein kinases, are required for early specification. However, little is known about the molecular mechanisms underlying these RLK-mediated signaling pathways. Here, we show that CLAVATA3 INSENSITIVE RECEPTOR KINASEs (CIKs), a group novel coreceptor kinase-controlling stem...
Potato is an important food crop and its production susceptible to drought. Drought stress in growth usually multiple- or long-term. In this study, the drought tolerant potato landrace Jancko Sisu Yari was treated with stress, rehydration re-dehydration, RNA-seq applied analyze characteristics of gene regulation during these treatments. The results showed that drought-responsive genes mainly involved photosynthesis, signal transduction, lipid metabolism, sugar wax synthesis, cell wall...
Tree peony (Paeonia ostii) is an economically important ornamental plant native to China. It also notable for its seed oil, which abundant in unsaturated fatty acids such as α-linolenic acid (ALA). Here, we report chromosome-level genome assembly (12.28 Gb) of P. ostii. In contrast monocots with giant genomes, tree does not appear have undergone lineage-specific whole-genome duplication. Instead, explosive LTR expansion the intergenic regions within a short period (~ two million years) may...
Abstract Although arsenic trioxide (As2O3) induces apoptosis in a relatively wide spectrum of tumors, the sensitivity different cell types to this treatment varies great extent. Because reactive oxygen species (ROS) are critically involved As2O3-induced apoptosis, we attempted explore possibility that elevating cellular ROS level might be an approach facilitate apoptosis. Emodin, natural anthraquinone derivative, was selected because its semiquinone structure is likely increase generation...
AbstractThe intrinsic or acquired resistance to multiple drugs (MDR) of cancer cells remains one the main obstacles for chemotherapy. Development small molecule targeting hypoxia inducible factor-1 (HIF-1) has been recently proposed as strategy treatments drug-resistant solid tumors. In present study, emodin, proven a reactive oxygen species (ROS) generator by our previous work, was applied in combination with cisplatin and other chemotherapeutic multidrug resistant prostate carcinoma cell...
The focus of this study was to investigate the expression status Circ-vimentin (VIM) and further analyze its pathogenesis clinical significance in acute myeloid leukemia (AML) patients. Real-time quantitative polymerase chain reaction carried on Circ-VIM 113 AML patients 42 healthy controls. significantly upregulated compared with control positively correlated white blood cells (WBC) count. Receiver operating characteristic curve analysis indicated that performance could serve as a promising...
Hepatocellular carcinoma (HCC) is one of the most lethal malignant tumors. Cell division cycle associated 8 (CDCA8) an important multifactorial regulator in cancers. However, its up and downstream targets effects HCC are still unclear.A comprehensive bioinformatics analysis was performed using The Cancer Genome Atlas dataset (TCGA) to explore novel core oncogenes. We quantified CDCA8 levels tumors qRT-PCR. cell's proliferative, migratory, invasive abilities were detected a Counting Kit-8...
Catalytic deoxydehydration (DODH) of vicinal diols is carried out employing methyltrioxorhenium (MTO) as the catalyst and a sacrificial alcohol reducing agent. The reaction kinetics feature an induction period when MTO added last show zero-order in [diol] half-order dependence on [catalyst]. rate-determining step involves with alcohol, evidenced by KIE 1.4 large negative entropy activation (ΔS‡ = −154 ± 33 J mol–1 K–1). active form methyldioxorhenium(V) (MDO), which formed reduction or via...
Arsenic is a wide spread carcinogen associated with several kinds of cancers including skin, lung, bladder, and liver cancers. Lung one the major targets arsenic exposure. Angiogenesis pivotal process during carcinogenesis chronic pulmonary diseases, but role mechanism in regulating angiogenesis remain to be elucidated. In this study we show that short time exposure induces both human immortalized lung epithelial cells BEAS-2B adenocarcinoma A549. To molecular arsenic-inducing angiogenesis,...
Abstract Here, we report a high-quality draft genome of Chinese radish ( Raphanus sativus ) cultivar. This contains 387.73 Mb assembled scaffolds, 83.93% the scaffolds were anchored onto nine pseudochromosomes and 95.09% 43 240 protein-coding genes functionally annotated. 184.75 Mb (47.65%) repeat sequences was identified in genome. By comparative analyses against 10 other plant genomes, 2 275 780 gene families found unique to R. . is good reference for genomic study great value genetic...
Angiotensin II (Ang II) is the predominant effector peptide of renin–angiotensin system. Ang contributes to vascular remodeling in many cardiovascular diseases (eg, hypertension, atherosclerosis, restenosis, and aneurysm). Orphan nuclear receptor Nur77 has a crucial role functional regulation cells. The objective this study was define specific II–induced remodeling. expression initially found be elevated medial smooth muscle cells (VSMCs) thoracic aortas from mice continuously infused with...
The Foxo3 gene, belonging to the forkhead family, is one of classes transcription factors characterized by a DNA-binding domain, which usually considered being cancer suppressor gene. Circ-Foxo3 circular structure connects 3'end 5'end. Scholars detected that circ-Foxo3 could compete with for binding some miRNAs.In this study, we will test expression and in de novo acute myeloid leukemia (AML) patients explore relationship between gene circ-Foxo3. All AML samples normal control was measured...