A5082781988- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Asthma and respiratory diseases
- Epigenetics and DNA Methylation
- IL-33, ST2, and ILC Pathways
- Gut microbiota and health
- Neonatal Respiratory Health Research
- Molecular Biology Techniques and Applications
- Animal Nutrition and Physiology
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory and Cough-Related Research
- Adipose Tissue and Metabolism
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Pediatric health and respiratory diseases
- Glaucoma and retinal disorders
- Lipid metabolism and disorders
- Immune Response and Inflammation
- Vitamin C and Antioxidants Research
- Allergic Rhinitis and Sensitization
- Pulmonary Hypertension Research and Treatments
- Pancreatic function and diabetes
- Peroxisome Proliferator-Activated Receptors
Northwest A&F University
2017-2025
Central South University
2024
Soochow University
2018-2022
University Hospital of Basel
2014-2021
Xi'an Jiaotong University
2008-2021
University of Basel
2015-2021
Agriculture and Forestry University
2021
Wuxi Ninth People's Hospital
2019
Wuxi No.2 People's Hospital
2018
Ministry of Education of the People's Republic of China
2014
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis. The kinase inhibitor nintedanib specific for vascular endothelial growth factor receptor (VEGFR), platelet-derived (PDGFR) and fibroblast (FGFR) significantly reduced the rate of decline forced vital capacity versus placebo.To determine in vitro effect on primary human fibroblasts.Fibroblasts were isolated from lungs IPF patients non-fibrotic controls. We assessed VEGF, PDGF-BB basic FGF (bFGF) ± on: (i)...
Cholesterol metabolism disorder in hepatocytes predicts a higher risk of metabolic syndrome (MetS). Long noncoding RNAs (lncRNAs) have emerged as critical players cellular cholesterol metabolism, but their functions are not systematically clarified. Here, we identified novel lncRNA named lnc‐HC negatively regulating within through physical interaction with hnRNPA2B1. By further binding to the target messenger RNA Cyp7a1 or Abca1 , ‐hnRNPA2B1 complex decreases expressions two genes that...
Abdominal fat or fatty liver cause huge economic losses in the poultry industry, and nonalcoholic disease (NAFLD) is also a global health issue humans. More than 90% of de novo lipogenesis humans chickens undertaken by liver, which proved to be full lipids new-born chickens. Folic acid was thought have correlation with lipid metabolism. Primary hepatocytes from were employed as natural model early stage vitro further explore whether folic could prevent current study. We found that addition...
A study was conducted to the effects of glucose oxidase (GOD) supplement on growth performance, gut function, and cecal microbiota in broiler chickens from 1 42 d, further evaluate use GOD as an antibiotic substitution. total 525 1-d-old healthy Arbor Acres broilers were randomly assigned five treatments, including control group, promoters (AGP) three groups, with seven replicates per treatment 15 birds replicate. Growth function digestive ability barrier, determined. Compared increased...
Abstract This study investigated the influence of Bacillus ‐based probiotics on performance and intestinal health in broiler challenged with Clostridium perfringens ‐induced necrotic enteritis. One‐day‐old Arbor Acre ( n = 480) were randomly assigned to four treatments 10 cages 12 birds: (a) basal diet negative control (NC), no nor antibiotics formulated contain 2,930 3,060 kcal/kg 24.07 15.98% CP, for starter finisher diet, respectively, (b) + enramycin (5 mg/kg), an antibiotic growth...
Pneumonia caused by methicillin-resistant Staphylococcus aureus (MRSA) continues to carry a high burden in terms of mortality. With the roles gut microbiota mediating lung diseases being gradually uncovered, details molecular mechanism "gut-lung axis" mediated beneficial microorganisms and small-molecule metabolites have attracted attention researchers. However, further studies are still necessary determine efficacy microbial-based interventions. Our findings indicate that sodium butyrate...
Abstract Protein arginine methyltransferase (PRMT)1, methylating both histones and key cellular proteins, has emerged as a regulator of various processes. This study aimed to identify the mechanism that regulates PRMT1 in chronic Ag-induced pulmonary inflammation (AIPI) E3 rat asthma model. rats were challenged with OVA for 1 or 8 wk induce acute AIPI. Expression mRNAs was detected by real-time quantitative PCR. PRMT1, TGF-β, COX2, vascular endothelial growth factor protein expression lung...
Abstract Tissue remodeling of subepithelial mesenchymal cells is a major pathologic condition chronic obstructive pulmonary disease and asthma. Fibroblasts contribute to fibrotic events inflammation in both airway diseases. Recent mechanistic studies established link between mitochondrial dysfunction or aberrant biogenesis leading tissue the wall Protein arginine methyltransferase-1 (PRMT1) participated inflammation. This study investigated mechanism by which PRMT1 regulates mass primary...
Hypoimmunity and numerous stresses are two major challenges in broiler industry. Nutrient intervention at the specific time of embryonic stage is a feasible way to improve animal performance. This study was conducted investigate possible effects ovo feeding (IOF) vitamin C age 15th day (E15) on growth performance, antioxidation immune function broilers. A total 240 fertile eggs were randomly divided into groups (0 3 mg injected dose E15), new-hatched chicks from each treatment allocated six...
The patho-mechanism leading to airway wall remodeling in allergic asthma is not well understood and resistant therapies. This study assessed the effect of immunoglobulin E (IgE) absence allergens on human primary smooth muscle cell (ASMC) vitro. ASMCs were obtained from five patients controls. Proliferation was determined by direct counts, mitochondrial activity expression cytochrome c, protein immunoblotting immuno-fluorescence, migration microscopy imaging, collagen deposition based ELISA...
Protein arginine methyltransferases (PRMTs), catalyzing methylation of both histones and other cellular proteins, have emerged as key regulators various processes. This study aimed to identify PRMTs involved in Ag-induced pulmonary inflammation (AIPI), a rat model for asthma, explore the role PRMT1 IL-4-induced eosinophil infiltration process. E3 rats were i.p. sensitized with OVA/alum intranasally challenged OVA induce AIPI. The expressions PRMT1-6, eotaxin-1, CCR3 lungs screened by...
Abstract Pdcd4 has been known as a tumor-suppressor gene initially and is up-regulated during apoptosis. Surprisingly, we found that was differentially expressed in the lung from E3 rats with AIPI, an animal model for asthma, but precise role of AIPI still remained to be defined. In present study, first evaluated expression control RT-qPCR, Western blot, immunohistochemistry. Then, investigated effects intervention on markers macrophage alternative activation airway remodeling. Upon...
Bronchial thermoplasty (BT) is to date the only therapy that provides a lasting reduction in airway wall remodelling. However, mechanism of action BT not well understood. This study aimed characterise changes remodelling regulating signalling pathways by asthma.Bronchoalveolar lavage fluid (BALF) was obtained from eight patients with severe asthma before and after BT. Primary bronchial epithelial cells were isolated 23 (n=66) (n=62) Epithelial cell culture supernatant (Epi.S) collected...
Abstract Protein arginine methyltransferase 1 (PRMT1) catalyzes methylation of histones and other cellular proteins, thus regulates gene transcription protein activity. In antigen-induced pulmonary inflammation (AIPI) PRMT1 was up-regulated in the epithelium, while chronic AIPI, increased shifted to fibroblasts. this study we investigated cell type specific regulatory mechanism PRMT1. Epithelial cells fibroblasts were stimulated with IL-4 or IL-1β. Gene expression determined by RT-qPCR,...
The therapeutic administration of recombinant proteins is utilized in a multitude research studies for treating various diseases. In this study, we investigate the potential Orosomucoid 2 (Orm2), an acute phase protein predominantly secreted by hepatocytes, non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH). Our results show that high Orm2 expression prevents high-fat-diet (HFD)-induced obesity mice. Pharmacological ORM2 ameliorates hepatic steatosis, inflammation,...
Early nutrition of pullets could determine the overall development and performance laying hens. With aim to reduce use antibiotic growth promoters (AGPs) maintain pullets, effect simultaneous short-termed supplementation AGPs (bacitracin zinc 20 mg/kg colistin sulfate 4 mg/kg) Bacillus subtilis (B. subtilis) DSM17299 probiotic, as well during whole period (0~16 weeks) on development, intestinal health, caecal microbiota were evaluated. In present study, a total 630 one-day-old Hy-Line Brown...
Scope Orosomucoid 2 (Orm2) is a hepatocyte‐secreted protein that plays crucial role in regulating obesity‐type metabolic disease and immunity. The imbalance of gut microbiota one the causes obesity, but mechanism relationship between Orm2 obesity remains unclear. Methods results Orm2‐/‐ (Orm2 knockout) mice on normal diet developed spontaneous disturbances at 20th week. Through 16S rRNA gene sequencing, study finds has different microbial composition compared to wild type (WT) mice....
Heat-induced stress has a significant impact on the health of broilers. It induces panting behavior and elevates oxygen consumption, leading to considerable strain broiler lungs. However, precise effects heat lung injury, along with changes in gut microbiota, are not yet fully understood. In our study, Arbor Acres (AA) broilers were employed as model assess efficacy sodium butyrate (SB) mitigating stress-induced while concurrently exploring potential role microbiota this phenomenon. Heat...