A5012871384- Sarcoma Diagnosis and Treatment
- Ear and Head Tumors
- Musculoskeletal synovial abnormalities and treatments
- Bone Tumor Diagnosis and Treatments
- Cardiac tumors and thrombi
- Tumors and Oncological Cases
- Testicular diseases and treatments
- Neuroblastoma Research and Treatments
- Childhood Cancer Survivors' Quality of Life
- Vascular Tumors and Angiosarcomas
- Renal and related cancers
- Radiopharmaceutical Chemistry and Applications
- Salivary Gland Tumors Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Intraperitoneal and Appendiceal Malignancies
- Acute Lymphoblastic Leukemia research
- CAR-T cell therapy research
- Soft tissue tumors and treatment
- Lymphoma Diagnosis and Treatment
- Chemotherapy-induced cardiotoxicity and mitigation
- Urologic and reproductive health conditions
- Management of metastatic bone disease
- Head and Neck Surgical Oncology
- RNA Interference and Gene Delivery
Children's Hospital of Los Angeles
2019-2023
University of Southern California
2019-2022
The University of Texas MD Anderson Cancer Center
2011-2021
Children's Center
2019
St. Jude Children's Research Hospital
2018
Pediatrics and Genetics
2012-2017
The University of Texas at Austin
2013-2015
Scripps MD Anderson Cancer Center
2010
Memorial Hermann
2009
Weatherford College
2008
Background Colorectal cancer (CRC) incidence is increasing in adults younger than 50 years. This study evaluated clinical and molecular features to identify those unique early‐onset CRC that differentiate these patients from years old or older. Methods Baseline characteristics were according the onset age with 3 independent cohorts. A fourth cohort was used describe impact of on consensus subtype (CMS) prevalence. Results retrospective review more 36,000 showed likely have microsatellite...
The effects of metal ions released from orthopedic implants on nearby bone cells remain largely unknown. purpose this study was to examine the acute toxicity osteogenic derived marrow. Bone marrow stromal were cultured with found in commonly used implants, that is, Ti-6Al-4V, Co-Cr-Mo, and 316L stainless steel. Solutions individual combinations representing alloy composition prepared atomic absorption standards added cultures give concentrations ranging 50 ppb ppm. After a 48-h period...
Abstract Background Traditionally, physicians have believed that limb‐salvage surgery has functional and cosmetic advantages over amputation, yet the literature is equivocal. Therefore, we sought to compare psychosocial outcomes in osteosarcoma survivors after amputation. We hypothesized there be neither nor outcome differences between groups. Procedure Participants received treatment of extremity osteosarcoma, had their cancer diagnosis at least 2 years prior, were 16 old. A comprehensive...
Abstract Purpose: Desmoplastic small round cell tumor (DSRCT), which harbors EWSR1-WT1 t(11;22)(p13:q12) chromosomal translocation, is an aggressive malignancy that typically presents as intra-abdominal sarcomatosis in young males. Given its rarity, optimal treatment has not been defined. Experimental Design: We conducted a retrospective study of 187 patients with DSRCT treated at MD Anderson Cancer Center over 2 decades. Univariate and multivariate regression analyses were performed....
Abstract Background There are limited data regarding the differences in clinical presentation and outcome of liposarcomas between adult pediatric patients. The role adjuvant radiotherapy treatment childhood liposarcoma is unclear. Procedure A multi‐institutional retrospective analysis medical records was performed for patients ≤21 years age presenting with a verified histologic diagnosis liposarcoma. Results Thirty‐three were evaluable this study, 23 whom male. Median 17.2 years. Twenty‐four...
Purpose This non-randomized, patient-access protocol, assessed both safety and efficacy outcomes following liposomal muramyl-tripeptide-phosphatidylethanolamine (L-MTP-PE; mifamurtide) in patients with high-risk, recurrent and/or metastatic osteosarcoma. Methods Patients received mifamurtide 2 mg/m2 intravenously twice-weekly ×12 weeks, then weekly ×24 weeks without chemotherapy. Serum concentration-time profiles were collected. Adverse events within 24 hours of drug administration...
BACKGROUND To the best of authors' knowledge, there has been relatively little research published to date regarding very long‐term survivors childhood and adolescent osteosarcoma. In current study, authors compared survival outcomes patients with osteosarcoma who were treated either limb salvage procedures or amputation. METHODS A total 38 survived ≥ 20 years from time diagnosis divided into 2 groups according whether they underwent amputation salvage. Participants asked complete a...
Abstract Background Alveolar soft part sarcoma (ASPS) is a rare mesenchymal tumor characterized by ASPL‐TFE3 translocation. Apart from complete surgical resection, there no standard management strategy. Procedure The clinical data of 69 children and young adults less than 30 years old with ASPS diagnosed 1980–2014 were retrospectively collected four major institutions. Results Median age at diagnosis was 17 (range: 1.5–30). Forty‐four (64%) female. follow‐up 46 months 1–409). Most common...
The purpose of this study is to evaluate the clinical, pathologic, and multimodality cross-sectional imaging features a cohort 94 patients with desmoplastic small round cell tumor (DSRCT).This retrospective pathologically verified DSRCT was conducted at tertiary cancer center between 2001 2013. Epidemiologic, findings were recorded. Tumor size, location, shape distribution pattern metastases presentation analyzed.DSRCT most often occurred in young (median age, 21.5 years; range, 5-53 years),...
The prognosis of metastatic osteosarcoma continues to be poor. We hypothesized that alpha-emitting, bone-targeting radium 223 dichloride (223RaCl2) can safely administered patients with and early signals response or resistance assessed by quantitative qualitative correlative imaging studies biomarkers.A 3+3 phase I, dose-escalation trial 223RaCl2 (50, 75, 100 kBq/kg) was designed in recurrent/metastatic aged ≥15 years. Objective measurements included changes standardized uptake values...
Chemotherapy during radiation and/or bone-seeking radioisotope therapy (153-samarium; 1 mCi/kg) may improve osteosarcoma cancer control.We analyzed our preliminary experience in high-risk, metastatic, recurrent patients a consecutive period of 20 months (May 2005-December 2006).Thirty-nine high-risk had radiotherapy; 119 sites were irradiated. A median four irradiated per patient (range 1-14). The dose and number fractions was 30 Gy 10 10-70 4-35 fractions). Chemotherapy, most commonly...
The survival of patients with advanced osteosarcoma is poor limited therapeutic options. There an urgent need for new targeted therapies based on biomarkers. Recently, theranostic molecular profiling services cancer by CLIA-certified commercial companies as well in-house in academic medical centers have expanded exponentially. We evaluated profiles whose tumor tissue had been analyzed one the following methods: 1. 182-gene next-generation exome sequencing (Foundation Medicine, Boston, MA),...
Pediatric jaw osteosarcoma is uncommon, and data are scarce regarding clinical presentation, prognostic factors, outcome.A single-institution medical record review from 1983 to 2008 for 12 patients age ≤ 21 years was undertaken this study.Median diagnosis 16.3 (range, 6.3-21.9). Nine had mandible tumors. Osteoblastic subtype most common (4 patients). Most tumors were large (ie, T2; n = 8) high-grade (n 8). Treatment characteristics varied. Median follow-up 27.1 months 8-252 months). Five...
Abstract Background Desmoplastic small round cell tumor (DSRCT) is an aggressive, often fatal soft tissue sarcoma that lacks optimal salvage regimen. We retrospectively reviewed data from 29 pretreated DSRCT patients who received pazopanib at MD Anderson Cancer Center after failure of standard chemotherapies. Subjects, Materials, and Methods Medical records treated January 2012 to December 2016 were regression analyses performed. Median progression-free survival (PFS) overall (OS) estimated...