A5012361899- Head and Neck Surgical Oncology
- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Sinusitis and nasal conditions
- Ear and Head Tumors
- Meningioma and schwannoma management
- Oral and Maxillofacial Pathology
- Bone Tumor Diagnosis and Treatments
- Tumors and Oncological Cases
- Pituitary Gland Disorders and Treatments
- Tracheal and airway disorders
- Infectious Diseases and Mycology
- Nonmelanoma Skin Cancer Studies
- Cancer Diagnosis and Treatment
- Cutaneous Melanoma Detection and Management
- Adrenal and Paraganglionic Tumors
- Lung Cancer Treatments and Mutations
- Immune Response and Inflammation
- Dysphagia Assessment and Management
- Voice and Speech Disorders
- Thyroid Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Sarcoma Diagnosis and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Head and Neck Anomalies
The University of Texas MD Anderson Cancer Center
2015-2024
Weatherford College
2023
Anderson University - South Carolina
2021
Scripps MD Anderson Cancer Center
2010-2014
University of Houston
2013
Sun Yat-sen University
2012
Sun Yat-sen University Cancer Center
2012
Baylor College of Medicine
2012
State Key Laboratory of Oncology in South China
2012
University of Pennsylvania
2000-2004
To evaluate the oncologic outcomes of patients with sinonasal cancer treated endoscopic resection.Retrospective review.Tertiary care academic center.All biopsy-proved malignant neoplasm region who were resection between 1992 and 2007 included in study, their charts reviewed for demographics, histopathologic findings, treatment details, outcome.Oncologic outcomes, including disease recurrence survival.Of a total 120 patients, 93 (77.5%) underwent an exclusively approach (EEA) 27 (22.5%)...
Large patient cohorts are necessary to validate the efficacy of transoral robotic surgery (TORS) in management head and neck cancer.To review oncologic outcomes TORS from a large multi-institutional collaboration identify predictors disease recurrence disease-specific mortality.A retrospective records 410 patients undergoing for laryngeal pharyngeal cancers January 1, 2007, through December 31, 2012, was performed. Pertinent data were obtained 11 participating medical institutions.Select...
Abstract BACKGROUND: Sinonasal mucosal melanoma is a rare disease associated with very poor prognosis. Because most of the series extend retrospectively several decades, we sought to determine prognostic factors and outcomes recent treatment modalities. METHODS: A retrospective chart review 58 patients treated for sinonasal at tertiary cancer center between 1993 2004. The were staged according American Joint Committee on Cancer (AJCC) staging system. Demographic, clinical pathological...
Mucoepidermoid carcinoma (MEC) is the most common malignancy of major salivary glands. Prior reports noted histological grade and tumor stage as consistently important prognostic factors. This study reviewed experience patients with MEC at University Texas MD Anderson Cancer Center to determine impact clinical pathologic findings on disease outcomes.A retrospective review was performed gland treated a tertiary cancer center from 1990 2007.A total 125 were included. The 5-year overall...
Sunitinib malate is a multitargeted receptor tyrosine kinase inhibitor used in the treatment of human malignancies. A substantial number sunitinib-treated patients develop cardiac dysfunction, but mechanism sunitinib-induced cardiotoxicity poorly understood. We show that mice treated with sunitinib and coronary microvascular dysfunction exhibit an impaired response to stress. The physiological changes caused by are accompanied depletion pericytes. Pericytes cell type dependent on intact...
Although lymphatic metastasis does not affect overall survival for patients with differentiated thyroid carcinoma, locoregional control can be improved cervical lymphadenectomy. The major morbidity of neck dissection (ND) the management regional metastases is spinal accessory (cranial nerve XI) dysfunction. To avoid this complication, some surgeons have advocated a limited ND.To establish patterns lateral in carcinoma and role comprehensive ND, we performed review our experience...
Adenoid cystic carcinoma of the sinonasal tract is a rare cancer that accounts for 10% all malignancies at this site. The objective current study was to evaluate prognostic factors, treatment outcomes, recurrence patterns, and survival rates adenoid carcinoma.A retrospective chart review performed an academic tertiary referral center. Between 1990 2004, 105 patients were evaluated single institution. Demographics, presentation, anatomic site, Tumor, Lymph Node, Metastasis (TNM)...
Multimodal therapy is a well-established approach for the treatment of sinonasal undifferentiated carcinoma (SNUC); however, optimal sequence various treatments modalities yet to be determined. This study aimed assess role induction chemotherapy (IC) in guiding definitive patients with SNUC.Ninety-five previously untreated diagnosed SNUC and treated between 2001 2018 at The University Texas MD Anderson Cancer Center were included analysis. Patients curative intent received IC before...
Abstract BACKGROUND: Adenoid cystic carcinoma (ACC) is characterized by slow growth, frequent local recurrences, and distant metastasis (DM). However, these findings frequently are reported in patients with advanced‐stage tumors, but the outcomes of early‐stage tumors poorly defined. We sought to evaluate risk factors for development DM ACC. METHODS: retrospectively reviewed charts 60 who were diagnosed clinical (T1‐2/N0) ACC determine survival patients. RESULTS: was detected 12 (20%)...
<h3>Objective</h3> To review the oncologic outcomes in patients with advanced (stage III-IV) squamous cell carcinoma of paranasal sinuses treated induction chemotherapy prior to definitive local therapy. <h3>Methods</h3> The medical records 46 consecutive previously untreated, biopsy-proved who received during course their treatment were reviewed for demographics, tumor types and stages, details, outcomes. <h3>Results</h3> Of (median age, 59 years), epicenter was maxillary sinus 31 (67%),...
Salivary gland adenoid cystic carcinoma (ACC) has heterogeneous clinical behavior. Currently, all patients are treated uniformly, and no standard-of-care systemic therapy exists for metastatic ACC. We conducted an integrated proteogenomic analyses of ACC tumors to identify dysregulated pathways propose a classification with therapeutic implications.RNA/DNA sequencing 54 flash-frozen salivary ACCs reverse phase protein array (RPPA) in 38 specimens were performed, validation by Western...
Esthesioneuroblastoma is a rare cancer of the anterior cranial base that arises in region olfactory rootlets. The purpose this study was to review long-term outcomes patients diagnosed with esthesioneuroblastoma (ENB) treated at single institution determine factors associated improved disease control and survival.A retrospective 70 ENB University Texas MD Anderson Cancer Center between 1992 2007 undertaken. Survival recurrence analyzed compared using Kaplan-Meier method log-rank...
Background The purpose of this study was to determine the antitumor activity epidermal growth factor receptor (EGFR) inhibitor gefitinib in patients with recurrent/metastatic salivary gland cancer. Methods We conducted a phase II adenoid cystic carcinoma (ACC) and non-ACC. Gefitinib administered 250 mg orally daily. primary endpoint tumor response. Secondary endpoints included progression-free survival (PFS), overall (OS), disease control rates. EGFR human 2 (HER2) expression were evaluated...
6500 Background: ECOG-ACRIN 3311 examines reduced postoperative therapy in patients with “intermediate risk” p16+ oropharynx cancer (OPC) undergoing primary transoral surgical management. We report the endpoint of 2-year progression free survival (PFS) for randomized to 50Gy vs 60Gy without chemotherapy. Methods: Between December 2013 and July 2017, 82 credentialed surgeons performed resection (TOS) 519 OPC (cT1-2 stage III/IV AJCC7 matted neck nodes); post-operative management was...
Squamous cell carcinoma is the most common type of sinonasal malignancy. Despite improvements in surgical resection and adjuvant therapy, which are considered standard care, outcome for patients with locoregionally advanced disease remains poor. The objective this study was to investigate role induction chemotherapy squamous determine oncologic outcomes those patients.The included 123 consecutive previously untreated, (stage III IV) who were treated curative intent at University Texas MD...
We conducted a phase II trial evaluating the efficacy of VEGFR inhibitor axitinib and PD-L1 avelumab in patients with recurrent/metastatic adenoid cystic carcinoma (R/M ACC).
To describe a novel robotic surgical approach that allows adequate endoscopic access for resection of tumors involving the anterior and central skull base 2-handed, tremor-free, dissection precise suturing dural defects.Transnasal approaches are being increasingly used base. One major disadvantage this is inability to provide watertight closure reconstruction, which limits its safety widespread adoption in surgery intracranial tumors. Other disadvantages include limited depth perception...