A5086320684- Head and Neck Cancer Studies
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Head and Neck Surgical Oncology
- Radiomics and Machine Learning in Medical Imaging
- Dysphagia Assessment and Management
- Salivary Gland Tumors Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- RNA modifications and cancer
- Esophageal and GI Pathology
- Tracheal and airway disorders
- Cancer-related molecular mechanisms research
- Brain Metastases and Treatment
- Oral health in cancer treatment
- Reconstructive Surgery and Microvascular Techniques
- Voice and Speech Disorders
- Cancer-related Molecular Pathways
- Tumors and Oncological Cases
- Lung Cancer Research Studies
- Nonmelanoma Skin Cancer Studies
- Global Cancer Incidence and Screening
- Polyomavirus and related diseases
- Genetic factors in colorectal cancer
- Molecular Biology Techniques and Applications
- Antenna Design and Analysis
The University of Texas MD Anderson Cancer Center
2020-2025
Fox Chase Cancer Center
2012-2021
Temple University Health System
2013-2020
Temple University
2008-2020
Louisiana State University
2018
Temple University Hospital
2006-2014
Philadelphia University
2006
Palmetto Hematology Oncology
2006
UPMC Hillman Cancer Center
2000-2003
University of Pittsburgh
2002
Epidermal growth factor receptor (EGFR) is overexpressed in head and neck squamous cell carcinoma (HNSCC) where expression levels correlate with decreased survival. Therapies that block EGFR have shown limited efficacy clinical trials primarily when combined standard therapy. The most common form of mutant (EGFRvIII) has been described several cancers, chiefly glioblastoma. present study was undertaken to determine the incidence EGFRvIII HNSCC biological consequences on tumor response...
Definitive or postoperative chemoradiation (CRT) is curative for human papillomavirus-associated (HPV+) oropharynx cancer (OPC) but induces significant toxicity. As a deintensification strategy, we studied primary transoral surgery (TOS) and reduced radiation therapy (RT) in intermediate-risk HPV+ OPC.
Abstract Objectives/Hypothesis: Clinical and molecular patterns of head neck squamous cell carcinoma (HNSCC) in nonsmokers smokers may be different. Analysis these improve understanding management this disease. Study Design: three hundred five subjects were included (46 nonsmokers, 29 former smokers, 230 smokers). Subsets analyzed for p53 mutation, human papillomavirus (HPV), loss heterozygosity (LOH) at 10 chromosomal loci. Methods: information was common disease among the groups. The gene...
6500 Background: ECOG-ACRIN 3311 examines reduced postoperative therapy in patients with “intermediate risk” p16+ oropharynx cancer (OPC) undergoing primary transoral surgical management. We report the endpoint of 2-year progression free survival (PFS) for randomized to 50Gy vs 60Gy without chemotherapy. Methods: Between December 2013 and July 2017, 82 credentialed surgeons performed resection (TOS) 519 OPC (cT1-2 stage III/IV AJCC7 matted neck nodes); post-operative management was...
BACKGROUND Left ventricular hypertrophy is a generalized adaptation to increased afterload, but the growth factors mediating this response have not been identified. To explore whether hypertrophic was associated with changes in local insulin-like factor-I (IGF-I) gene regulation, we examined induction of cardiac IGF-I three models systolic hypertension and resultant hypertrophy. METHODS AND RESULTS The model systems were suprarenal aortic constriction, uninephrectomized spontaneously...
The purpose of this study was to report associations between p16 status, clinicopathologic characteristics, and outcomes for head neck squamous cell carcinoma unknown primary (CUP).Specimens CUP were reanalyzed. Human papillomavirus (HPV) status determined by stain. A tissue microarray (TMA) constructed evaluate biomarkers potentially prognostic in (HNSCC).A majority the population (n = 26; 74%) positive (+). Prognostic factors benefiting survival p16+ (p < .0001), absence macroscopic...
The impact of extranodal extension (ENE) metastatic papillary thyroid carcinoma (PTC) on short- and long-term clinical outcomes, including biochemical testing, has not been reported.This single-institution National Cancer Institute-designated Comprehensive Center cohort study included patients with macroscopic metastases excluded gross residual disease after surgery, distant disease, or poorly differentiated carcinoma. A suppressed stimulated thyroglobulin (Tg) < 1 ng/mL, without suspicious...
Head/neck sarcomas are rare, accounting for about 1% of head/neck malignancies and 5% sarcomas. Outcomes have historically been worse in this group, due to anatomic constraints leading difficulty completely excising tumors, with high rates local recurrence. We retrospectively analyzed cases soft tissue (STS) osteogenic managed a multi-disciplinary setting at Fox Chase Cancer Center from 1999-2009 describe clinicopathologic characteristics, treatment, outcomes, prognostic factors disease...
Clinical decision making for human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) is predominantly guided by disease stage anatomic location, with few validated biomarkers. The epidermal growth factor receptor (EGFR) an important therapeutic target, but its value in guiding remains ambiguous. We integrated analysis of clinically annotated tissue microarrays data available through the TCGA, to investigate idea that expression signatures involving EGFR, proteins...
6009 Background: E3311 is a phase II trial of TOS by credentialed surgeons with pathology-driven deintensified post-operative management in HPV+ OPC. Intermediate risk patients were randomized between standard and reduced dose radiation. We present mature outcome data, at median follow up 52.4 months (m). Methods: Patients eligible who had resectable cT1-2 stage III/IV AJCC7 p16+ OPC without matted neck nodes. Those clear margins, 0-1 + nodes (LN), no extranodal extension (ENE) observed (Arm...
ABSTRACT Prognosis for patients with recurrent/metastatic (R/M) head and neck squamous cell cancer (HNSCC) remains poor. We hypothesized that the addition of an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) to standard therapy would improve responses by inhibiting nuclear translocation EGFR designed a phase 2 trial chemotherapy, cetuximab erlotinib in R/M HNSCC. 24 were enrolled treated carboplatin, paclitaxel administered 21-day cycles. Erlotinib was added cycle 2....
Abstract Background Pathologic extranodal extension (pENE) is a crucial prognostic factor in oropharyngeal cancer (OPC), but determining pENE from imaging has high inter‐observer variability. The role of clinician specialty the accuracy imaging‐detected (iENE) remains unclear. purpose this study to assess influence on preoperative iENE detection human papillomavirus (HPV)‐positive OPC using computed tomography (CT) imaging. Methods This prospective observational evaluated pretherapy CT...
Objective: Patient-reported outcomes (PROs) contain valuable information that can be leveraged by providers to perform timely interventions and improve quality of life survival. However, the implementation electronic PROs (ePROs) remains a challenge from technical, behavioral, evaluation perspectives. Our objective was construct robust health record (EHR)-integrated ePRO infrastructure founded on RE-AIM (Reach-Effectiveness-Adoption-Implementation-Maintenance) principles. Materials Methods:...
Prognosis for patients with recurrent/metastatic (R/M) head and neck squamous cell cancer (HNSCC) remains poor. We hypothesized that the addition of an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) to standard therapy would improve responses by inhibiting nuclear translocation EGFR designed a phase 2 trial chemotherapy, cetuximab, erlotinib in R/M HNSCC. A 24 were enrolled treated carboplatin, paclitaxel, cetuximab administered 21-day cycles. Erlotinib was added...
Abstract Background. The impact of posttreatment neck dissection on prolonged feeding tube dependence in patients with head and squamous cell cancer (HNSCC) treated primary radiation or chemoradiation remains unknown. Methods. We conducted a retrospective cohort study using propensity score adjustment to investigate the effect dependence. Results. A review 67 node‐positive HNSCC (T1‐4N1‐3), chemoradiation, no evidence tumor recurrence follow‐up at least 24 months, was performed. Following...
BACKGROUND In head and neck cancer patients prior to treatment, dysphagia noted by is more common than aspiration on formal swallow studies. The authors hypothesized that patient‐reported impacts multiple domains of quality life (QOL) predicts disease recurrence disease‐related death. METHODS Swal‐QOL, a dysphagia‐specific, swallowing‐related, QOL measure, the EuroQOL‐5D‐3L were administered 159 before treatment with curative intent in this prospective cohort study. Logistic regression...
Objectives To describe the deployment of otolaryngologists and evaluate factors associated with geographic distribution in United States. Study Design Cross‐sectional study. Methods The otolaryngology physician supply was defined as number per 100,000 hospital referral region (HRR). derived from American Medical Association Masterfile or Medicare Enrollment Provider Utilization Files. Multiple linear regression tested association population, physician, on Medicare‐enrolled...
Background: Gastrin-releasing peptide receptor (GRPR)-mediated autocrine growth appears to be an early marker of susceptibility tobacco-related lung cancers. Because expression GRPR, however, has not been reported in squamous cell carcinoma the head and neck (SCCHN), we investigated its that ligand GRP normal mucosa SCCHN tissues involvement these proteins proliferation cells. Methods: We assessed GRPR messenger RNA (mRNA) specimens from 25 patients with SCCHN, six control noncancer...