A5057870347- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Tumors and Oncological Cases
- Ear and Head Tumors
- Head and Neck Surgical Oncology
- Cancer Diagnosis and Treatment
- Cancer-related gene regulation
- Myasthenia Gravis and Thymoma
- Oral Health Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Inflammatory mediators and NSAID effects
- Oral health in cancer treatment
- COVID-19 and healthcare impacts
- Estrogen and related hormone effects
- Cervical Cancer and HPV Research
- Cutaneous Melanoma Detection and Management
- Sarcoma Diagnosis and Treatment
- Head and Neck Anomalies
- Lung Cancer Treatments and Mutations
- Global Cancer Incidence and Screening
- Salivary Gland Disorders and Functions
- Reconstructive Surgery and Microvascular Techniques
- Radiomics and Machine Learning in Medical Imaging
- Oropharyngeal Anatomy and Pathologies
The University of Texas MD Anderson Cancer Center
2015-2025
University of Illinois Chicago
2008-2013
University of Chicago Medical Center
2010-2012
Stanford University
2011
Baylor College of Medicine
2009
Tulane University
2009
The University of Texas Southwestern Medical Center
2008
Medical College of Wisconsin
2002-2004
Abstract Background Pathologic extranodal extension (pENE) is a crucial prognostic factor in oropharyngeal cancer (OPC), but determining pENE from imaging has high inter‐observer variability. The role of clinician specialty the accuracy imaging‐detected (iENE) remains unclear. purpose this study to assess influence on preoperative iENE detection human papillomavirus (HPV)‐positive OPC using computed tomography (CT) imaging. Methods This prospective observational evaluated pretherapy CT...
To compare survival rates between patients with squamous cell carcinoma of the head and neck (SCCHN) without a history smoking (never smokers) those current or previous (ever smokers).Fifty never smokers newly diagnosed SCCHN were matched to 50 ever according sex, age, tumor site, overall stage, nodal treatment. Survival analysis was performed using Kaplan-Meier estimates. Matched-pair compared Cox proportional hazards model.The had greater (P =.020), disease-specific =.022), recurrence-free...
Background: The authors examined whether the preoperative serum concentrations of cotinine accurately predict risk complications in patients undergoing flap reconstruction head and neck cancer defects. Methods: Patients with incident stage III or IV squamous cell carcinoma resection pedicled free were selected from an existing database 500 who participated a prospective epidemiologic study reviewed retrospectively. Preoperative determined using competitive microplate immunoassay....
Abstract It is unknown whether population-level racial or ethnic disparities in mortality from squamous cell carcinoma of the head and neck (SCCHN) also occur setting standardized multidisciplinary-team directed care. Therefore, we conducted a matched-pair study that controlled for several potentially confounding prognostic variables to assess difference survival exists African American Hispanic compared with non-Hispanic white SCCHN patients receiving similar Matched pairs were 81 case...
To compare the survival rates of patients 40 years or younger and diagnosed with squamous cell carcinoma head neck (SCCHN) those older than who underwent same treatment. In 2 previous matched-pair analyses, had been matched for tumor stage, site, sex, date presentation but not type treatment.Between 1995 2001, 46 participated in a prospective epidemiologic study that included more 500 newly SCCHN. We each these by race, overall treatment modality years. Ultimately, 31 were 62 patients....
Objective: Previous studies have demonstrated consistent benefit in older adults undergoing cochlear implantation as compared with younger control groups, age category thresholds between 60 and 70 years. The objective of this study is to report auditory performance implant recipients than 75 years, a cohort for which few data been reported. Study Design: Retrospective chart review. Setting: Academic program tertiary-care hospital. Patients: Twenty-eight were subdivided into users 80 years...
The objective of this study was to evaluate the complication rate transtemporal cranioplasties using hydroxyapatite cement (HAC) for repair.We conducted a retrospective case review patients receiving HAC in Acoustic Neuroma and Skull Base Surgery Program between July 1998 December 2002.This at tertiary referral center.A total 76 were performed 72 undergoing lateral skull base surgery. Patients anterior surgery or those which used other reconstructive purposes excluded from study.We studied...
BACKGROUND Patients with advanced primary and recurrent salivary duct carcinoma (SDC), a rare lethal malignancy, have limited therapeutic options. Novel small‐molecule agents aimed at targeting critical signaling associated SDC tumorigenesis may lead to new options for patients these tumors. The human epidermal growth factor receptor 2 (HER2)/phosphoinositide 3‐kinase (PI3K) axis, an important oncogenic pathway, has been targeted therapy in several solid Currently, little is known about the...
Abstract Background This study reports long‐term head and neck cancer (HNC) patient‐reported symptoms using the MD Anderson Symptom Inventory Head Neck Cancer Module (MDASI‐HN) in a large cohort of HNC survivors. Methods MDASI‐HN results were prospectively collected from an institutional survivorship database. Associations with clinicopathologic data analyzed χ 2 , Mann‐Whitney, univariate regression. Results Nine hundred twenty‐eight patients included. Forty‐six percent had oropharyngeal...
Salivary gland carcinomas (SGCs) are pathologically classified into several widely diverse subtypes, of which adenoid cystic carcinoma (ACC), mucoepidermoid (MEC), and salivary duct (SDC) the most commonly encountered. A comparative genetic analysis these subtypes provides detailed information on alterations that associated with their tumorigenesis may lead to identification biomarkers guide tumor-specific clinical trials.Whole-genome sequencing 58 common SGCs (20 ACCs, 20 SDCs, 18 MECs) was...
Acinic cell carcinoma (AcCC) is a morphologically distinctive salivary gland malignancy often associated with chromosome rearrangements leading to overexpression of the NR4A3 transcription factor. However, little known about how contributes AcCC biology. Detailed RNA-sequencing 21 archived samples revealed fusion reads arising from recurrent t(4;9), t(9;12), t(8;9) or t(2;4) chromosomal translocations, which positioned highly active enhancers adjacent promoter
Abstract Background Swallowing therapy is commonly provided as a treatment to lessen the risk or severity of dysphagia secondary radiotherapy (RT) for head and neck cancer (HNC); however, best practice not yet established. This trial will compare effectiveness prophylactic (high low intensity) versus reactive interventions swallowing in patients with HNC undergoing RT. Methods multi-site, international randomized clinical (RCT) include 952 adult receiving who are at high post-RT dysphagia....
Objective: To assess the knowledge of first-(M1) and fourth-(M4) year medical students regarding head neck cancer (HNC) risk factors, signs, symptoms, frequency; designated oral screening recommendations; physical examination techniques; school curriculum on this subject.Design: Cross-sectional cohort study using a survey questionnaire.
Abstract Purpose: To determine the expression of glucocorticoid receptor (GR) and androgen (AR) in salivary duct carcinoma (SDC) to analyze role these proteins development management this disease entity. Experimental Design: We performed a phenotypic assessment GR AR localization expression, determined their association with clinicopathologic factors 67 primary SDCs. In vitro functional response analysis SDC cell lines was also performed. Results: Of tumors, 12 (18%) overexpressed protein,...