A5029830592- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Ear Surgery and Otitis Media
- Head and Neck Surgical Oncology
- Meningioma and schwannoma management
- Hearing Loss and Rehabilitation
- Ear and Head Tumors
- Ophthalmology and Eye Disorders
- Ion channel regulation and function
- Cerebral Venous Sinus Thrombosis
- Nicotinic Acetylcholine Receptors Study
- Neurofibromatosis and Schwannoma Cases
- Facial Nerve Paralysis Treatment and Research
- Neuropeptides and Animal Physiology
- Biochemical Analysis and Sensing Techniques
- Herpesvirus Infections and Treatments
- Glaucoma and retinal disorders
- Neuroscience of respiration and sleep
- Tracheal and airway disorders
- Trigeminal Neuralgia and Treatments
- Bone Tumor Diagnosis and Treatments
- Connexins and lens biology
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Anomalies
- Neuroscience and Music Perception
Johnson University
2016-2025
Rutgers, The State University of New Jersey
2016-2025
Rutgers Sexual and Reproductive Health and Rights
2025
Robert Wood Johnson University Hospital
2022
Creative Commons
2022
American Society of Neuroradiology
2022
May Institute
2022
Okayama Prefecture
2017
College Station Medical Center
2016-2017
Legacy Health
2012-2017
ContextChronic otitis media (OM) is a common pediatric infectious disease. Previous studies demonstrating that metabolically active bacteria exist in culture-negative middle-ear effusions and experimental infection with Haemophilus influenzae the chinchilla model of results formation adherent mucosal biofilms suggest chronic OM may result from biofilm infection.ObjectiveTo test hypothesis humans biofilm-related.Design, Setting, PatientsMiddle-ear mucosa (MEM) biopsy specimens were obtained...
In Brief Objective: The purpose of this study was to conduct a large-scale investigation with adult recipients the Clarion, Med-El, and Nucleus cochlear implant systems (1) determine average scores ranges performance for word sentence stimuli presented at three intensity levels (70, 60, 50 dB SPL); (2) provide information on variability each subject by obtaining test-retest measures all test conditions; (3) further evaluate potential use lower speech presentation (i.e., 60 and/or SPL) in...
Binaural hearing has been shown to support better speech perception in normal-hearing listeners than can be achieved with monaural stimulus presentation, particularly under noisy listening conditions. The purpose of this study was evaluate whether bilateral electrical stimulation could confer similar benefits for cochlear implant listeners.A total 26 postlingually deafened adult patients short duration deafness were implanted at five centers and followed up 1 yr. Subjects received MED-EL...
COVID-19 is a pandemic respiratory and vascular disease caused by SARS-CoV-2 virus. There growing number of sensory deficits associated with molecular mechanisms underlying these are incompletely understood.
A retrospective review of 373 adult patients admitted to Harbor General Hospital between 1980 and 1984 for minor closed head injury (Glasgow coma scale 13-15) was performed determine the benefits skull radiography, computed tomographic (CT) scanning head, admission observation. Variables reviewed were mental status, neurological examination, presence or absence loss consciousness, clinical evidence basilar fracture, fracture on radiography. The examination (including status Glasgow scale) in...
Objective This study evaluates the U.S. experience with first 40 patients who have undergone audiologic rehabilitation using BAHA bone-anchored hearing aid. Study Design is a multicenter, nonblinded, retrospective case series. Setting Twelve tertiary referral medical centers in United States. Patients Eligibility for implantation included loss and an inability to tolerate conventional aid, bone-conduction pure tone average levels at 60 dB or less 0.5, 1, 2, 4 kHz. Intervention met clinical...
The ultrastructure of ten normal human endolymphatic sacs (ES), fixed immediately after death and obtained at autopsy, was observed by transmission electron microscopy. roles the epithelium, subepithelial space, vasculature, ES leukocytes were morphologically studied to evaluate possible immunologic functions ES. In addition, five intraosseous biopsies from patients undergoing translabyrinthine acoustic neuroma resection using immunoperoxidase technique identify specific leukocyte...
Objective: This communication is the first assessment of outcomes after surgical repair cochlea-facial nerve dehiscence (CFD) in a series patients. Pre- and postoperative quantitative measurement validated survey instruments, symptoms, diagnostic findings anonymous video descriptions symptoms cohort 16 patients with CFD third window syndrome (TWS) were systematically studied. Study design: Observational analytic case-control study. Setting: Quaternary referral center. Patients: Group 1 had 8...
Objective/Hypothesis Frailty has emerged as a powerful risk stratification tool across surgical specialties; however, an analysis of the impact frailty on outcomes following skull base surgery not been published. The aim this study was to assess validity 5‐factor modified index (mFI‐5) predictor perioperative morbidity and mortality in patients undergoing surgery. Methods A mFI‐5 score calculated for surgeries using National Surgical Quality Improvement Program (NSQIP) database from 2005...
The striatum is the primary input nucleus of basal ganglia, integrating a dense plexus inputs from cerebral cortex and thalamus to regulate action selection learning. Neuroanatomical mapping its sub compartments has been carried out extensively in rats mice, non-human primates, cats allowing comparative neuroanatomy studies derive heuristics about striatal composition function. Here, we systematically map corticostriatal topography motor, somatosensory, auditory, visual cortices as well...
Abstract In 1907 J. Ramsay Hunt suggested that herpes zoster oticus resulted from a geniculate ganglionitis; however, many contemporary authors believe this disorder represents neuritis or polycranial neuropathy. Herpes varicella‐zoster viral (VZV) DNA was identified, using the polymerase chain reaction, in archival celloidin‐embedded temporal bone sections two patients who clinically had syndrome (herpes oticus). The presence of VZV confirmed by sequencing PCR products. These experiments...
Postmortem examination of the brain and temporal bones a patient with well-documented vestibular neuritis showed selective neuronal loss in Scarpa's ganglia on side absent caloric response. There was hair cells an "epithelialization" utricular macule semicircular canal cristae deafferented side, synaptic density nuclei decreased compared that normal side. All findings were consistent isolated viral infection ganglia. This is first description effects chronic deafferentation sensory epithelia...
AbstractA time sequence study of the effect hemilabyrinthectomy on endolymphatic sac was performed in mice. Light and transmission electron microscopy showed significant morphological changes epithelial lining adjacent structures. Initially (2 4 days post-labyrinthectomy) lumen collapsed, but later (7 it dilated or ‘ballooned’ filled with a darkly staining homogeneous substance. This substance, which has been identified histochemically as proteoglycan, appeared to be secreted from epithelium...
Preliminary studies show that bilateral cochlear implantation improves speech-recognition ability in many subjects; however, the magnitude of this improvement has been variable. The objective our research was to explore means better differentiate binaural benefit patients who receive implants (CIs) describe.Binaural improvements speech-perception performance will be consistently evident across when they are tested more challenging listening situations.This a prospective clinical study....
Elevated levels of hsa-microRNA-21 (miR-21) in vestibular schwannomas (VSs) may contribute to tumor growth by downregulating the suppressor phosphatase and tensin homolog (PTEN) consequent hyperactivation protein kinase B (AKT), a key signaling cellular pathways that lead growth.Vestibular are benign tumors arise from nerve. Left untreated, VSs can result hearing loss, tinnitus, dysfunction, trigeminal nerve even become life threatening. Despite efforts characterize VS transcriptome,...
Patients with peripheral vestibular dysfunction because of gravitational receptor asymmetries display signs cognitive and are assumed to have neurobehavioral sequelae. This was tested pre- postoperatively quantitative measurements in three cohort groups superior semicircular canal dehiscence syndrome (SSCDS) symptoms with: 1) (SCD) repaired via a middle cranial fossa craniotomy plugging only; 2) otic capsule defects not visualized imaging (no-iOCD) round window reinforcement (RWR) or 3) both...
Recent reports have emphasized free-flap reconstruction for large defects of the scalp and calvarium following resection tumors, infection, or trauma. In most cases, however, a carefully planned local transposition rotation flap may be equally effective, technical difficulties donor-site problems associated with microsurgical tissue transfer are then avoided. We present 10 patients whose full-thickness covered an average area 241 cm2, 27 percent, skull surface. Although this series included...
Objective: To determine the effectiveness of auditory steady-state response (ASSR) as a measure hearing sensitivity in young children suspect for significant loss.Design: Within-subject comparisons click brainstem (ABR) thresholds and ASSR thresholds. Subjects:The study population comprised 42 loss subsequently referred assessment using electrophysiologic techniques.Main Outcome Measures: Electrophysiologic threshold responses ABR stimuli (0.5, 1, 2, 4 kHz) right left ears.Results: Based on...
We conducted a prospective longitudinal study of two cohorts patients who had superior semicircular canal dehiscence syndrome (SSCDS); one group radiographically confirmed (SCD), and the other exhibited no identified otic capsule on imaging (no-iOCD). compiled data obtained from structured symptomatology interviews; diagnostic studies; three-dimensional, high-resolution, temporal bone computed tomography; retrospective case review our tertiary care referral center. Eleven adults 1 child with...
Abstract Objective/Hypothesis: In specific clinical situations, endoscopes offer better visualization than the microscope during acoustic neuroma (vestibular schwannoma) surgery and can therefore decrease incidence of postoperative complications cerebrospinal fluid (CSF) leakage recurrence tumor. This study was undertaken to determine if use adjunctive endoscopy provides complementary information operating surgeon for neuromas. Method: Seventy‐eight patients with neuromas underwent tumor...
The purpose of this paper is to describe a safe new technique for intraoperative identification the site cerebrospinal fluid rhinorrhea. Cerebrospinal (CSF) rhinorrhea after intracranial or intranasal surgery known potential complication with significant morbidity and mortality. It currently accepted that endoscopic management CSF preferred method surgical repair, higher success rates less than repair in selected cases. Accurate leakage necessary successful repair. Computer tomography (CT)...
The objective of this study was to determine the utility and safety rigid endoscopy as an adjunct during posterior fossa surgery treat cranial neuropathies.A suboccipital craniotomy performed for 19 patients with non-neoplastic processes involving Vth, VIIth, and/or VIIIth nerves. Ten trigeminal neuralgia (n = 8), hemifacial spasm 1), or intractable tinnitus 1) underwent primarily microvascular decompression procedures. One patient geniculate nervus intermedius sectioning combined...