Objective: This communication is the first assessment of outcomes after surgical repair cochlea-facial nerve dehiscence (CFD) in a series patients. Pre- and postoperative quantitative measurement validated survey instruments, symptoms, diagnostic findings anonymous video descriptions symptoms cohort 16 patients with CFD third window syndrome (TWS) were systematically studied. Study design: Observational analytic case-control study. Setting: Quaternary referral center. Patients: Group 1 had 8...

Background and objective The International Classification of Headache Disorders, Third Edition (ICHD-3), significantly influences clinicians’ understanding headache disorders. In this study, we aim to elucidate how the hierarchical structure ICHD-3 shapes interconnectivity among Methods A network comprises elements known as “nodes,” with connections between them referred “edges.” our a node represents diagnosis that meets at least one diagnostic criterion ICHD-3. We developed two models for...

Background: In clinical circumstances with more than one headache disorders, misrecognition can occur if each disorder is not separately and individually evaluated. For example, consider the case of a patient baseline tension type headaches lasting hours who now develops cluster nausea. Merging characteristics both disorders may yield illusion migraine. Do these types misrecognitions necessarily because ICHD3 criteria? Are there combinations criteria, any, which this misrecognition?...

Choosing migraine prevention medications often involves trial and error. Operations research methodologies, however, allow us to derive a mathematically optimum way conduct such error processes. Given probability of success (defined as 50% reduction in headache days) adverse events function time, we seek develop solve an operations model, applicable any arbitrary patient, minimizing time until discovery effective medication. We then apply our model real life data for chronic prevention. An...

Both S1 and XELOX (capecitabine+oxaliplatin) have been recommended as an adjuvant treatment for gastric cancer according to the guidelines of National Comprehensive Cancer Network (NCCN). This study compared two regimens in terms monetary costs, assuming equal efficacy both regimens. Chemotherapy cost data 188 patients were collected from medical records, 91 group 97 XELOX. Costs classified direct costs (chemotherapy, hospitalization, venous access, tests), adverse event-related treatments...

This project seeks to identify the top 30 drugs most commonly associated with headaches in U.S. Food and Drug Administration Adverse Event Reporting System (FAERS), as well their respective reporting odds ratios (RORs).Headache secondary medication use is a well-known entity. However, which medications are likely cause on global scale unknown.We extracted case identifiers, adverse events, attributed for entries FAERS database from July 1, 2018, March 31, 2020. Entries were split into two...

Abstract Background Stigmatization and trivialization of headache confront individuals with disorders, but the degree to which media may contribute is incompletely understood. Objective The objective this study was quantify frequency disparaging metaphorical use words “headache” “migraine” in articles summaries major publications. Methods This longitudinal analyzed a dataset 1.3 million written by authors editors 38 Data cover publications from 1998 up 2017. or rated two (P.Z. A.V.) as...

Background/objective Preventive medications are crucial in migraine prevention. In cases of refractory headaches, multiple may be required. We seek to identify a comprehensive list preventive headache that can used as two, three, and four drug combinations without drug–drug interactions. Methods compiled prevention from Szperka et al.’s “Migraine Care the Era COVID-19” well American Headache Society’s 2018 2021 “Consensus Statements on Integrating New Migraine Treatments into Clinical...

(1) Objective: Resting-state fMRI studies have indicated that juvenile myoclonic epilepsy (JME) could cause widespread functional connectivity disruptions between the cerebrum and cerebellum. However, directed influences or effective connectivities (ECs) these brain regions are poorly understood. In current study, we aimed to evaluate ECs cerebellum in patients with new-onset JME. (2) Methods: Thirty-four JME thirty-four age-, sex-, education-matched healthy controls (HCs) were included this...

Introduction Real-life headache presentations may fit more than one ICHD3 diagnosis. This project seeks to exhaustively list all logically consistent “co-diagnoses” according the criteria. We limited our cases of two concurrent diagnoses. Methods included criteria for “Migraine” (1.1, 1.2, 1.3), “Tension-type headache” (2.1, 2.2, 2.3, 2.4), “Trigeminal autonomic cephalalgias” (3.1, 3.2, 3.3, 3.4, 3.5), and “Other primary disorders.” also excluded “probable” diagnosis Each characteristic in...

Background: Polypharmacy in abortive medications is often inevitable for patients with refractory headaches. Objective: We seek to enumerate an exhaustive list of headaches that are without drug-drug interactions. Methods: updated a acute based on the widely used Jefferson Headache Manual novel including ubrogepant, lasmiditan, and rimegepant. Opioids barbiturate-containing products excluded. From this resultant medications, we then conducted search all pair-wise interactions via DrugBank's...

Introduction: The pace of emerging scientific literature far outstrips that guideline updates, yet clinical practice may require early implementation after careful review. Recently developed large language model (LLM) based machine learning systems are potential assistive tools to identify novel or research avenues as they emerge. Here we use GPT3.5, a LLM by OpenAI, evaluate 3 interventions for aneurysmal subarachnoid hemorrhage (aSAH), with comparison conclusions from systematic review,...

<sec> <title>BACKGROUND</title> Clinical trials demonstrate the efficacy and tolerability of medications targeting calcitonin gene–related peptide (CGRP) signaling for migraine prevention. However, these may not accurately reflect real-world experiences more diverse heterogeneous patient populations, who often have higher disease burden comorbidities. Therefore, postmarketing safety surveillance is warranted. Regulatory organizations encourage marketing authorization holders to screen...

Background Clinical trials demonstrate the efficacy and tolerability of medications targeting calcitonin gene–related peptide (CGRP) signaling for migraine prevention. However, these may not accurately reflect real-world experiences more diverse heterogeneous patient populations, who often have higher disease burden comorbidities. Therefore, postmarketing safety surveillance is warranted. Regulatory organizations encourage marketing authorization holders to screen digital media suspected...

Non-headache literature inevitably influences headache research, but the way this interdisciplinary interaction occurs has seldom been evaluated.Utilizing network analysis techniques within PubMed Central (PMC) database, we illustrate a novel method by which to identify and characterize important non-headache with significant impact world.Using National Center for Biotechnology Information E-utilities application programing interface custom backend software, all PMC articles containing words...

Differential diagnosis is fundamental to medicine. Using DiffNet, a differential generator, as model, we studied the structure and organization of how collections diagnoses (i.e., sets diagnoses) are related in ICHD3. Furthermore, explored clinical theoretical implication these answers.DiffNet freely distributed generator for headaches using graph properties ICHD3: (1) DiffNet considers each ICHD3 node. (2) An edge exists between two if they connected by either classification hierarchy or...

Background: Twitter is a leading microblogging platform, with over 126 million daily active users as of 2019, which allows for large-scale analysis tweets related to migraine. June 2020 encompassed the National Migraine and Headache Awareness Month in United States American Society’s virtual annual conference, offer opportunities us study online migraine advocacy. Objective: We aim content individual about migraine, well patterns other topics that were discussed those tweets. In addition, we...