A5035994064- Head and Neck Cancer Studies
- Oral health in cancer treatment
- Advanced Radiotherapy Techniques
- COVID-19 and healthcare impacts
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Cancer survivorship and care
- Cancer Diagnosis and Treatment
- Dysphagia Assessment and Management
- Head and Neck Surgical Oncology
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Treatment and Pharmacology
- Enhanced Recovery After Surgery
- Venous Thromboembolism Diagnosis and Management
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Voice and Speech Disorders
- Multiple Myeloma Research and Treatments
- CAR-T cell therapy research
- Salivary Gland Disorders and Functions
- Global Cancer Incidence and Screening
- Trauma and Emergency Care Studies
- Cerebrovascular and Carotid Artery Diseases
- biodegradable polymer synthesis and properties
- Neutropenia and Cancer Infections
The University of Texas MD Anderson Cancer Center
2017-2025
Case Western Reserve University
1976-2025
Mediclinic City Hospital
2025
Ain Shams University
2015-2023
University of Birmingham
2020-2022
Institut de Virologie
2020-2021
NIHR Birmingham Biomedical Research Centre
2021
Yorkshire Cancer Research
2021
Urology Foundation
2021
Association for Cancer Surgery
2021
Radiomics is one such "big data" approach that applies advanced image refining/data characterization algorithms to generate imaging features can quantitatively classify tumor phenotypes in a non-invasive manner. We hypothesize certain textural of oropharyngeal cancer (OPC) primary tumors will have statistically significant correlations patient outcomes as local control. Patients from an IRB-approved database dispositioned (chemo)radiotherapy for locally OPC were included this retrospective...
Accurate clinical target volume (CTV) delineation is essential to ensure proper tumor coverage in radiation therapy. This a particularly difficult task for head-and-neck cancer patients where detailed knowledge of the pathways microscopic spread necessary. paper proposes solution auto-segment these volumes oropharyngeal using two-channel 3D U-Net architecture. The first channel feeds network with patient's CT image providing anatomical context, whereas second provides location and...
Chimeric antigen receptor (CAR) T cell therapy is being increasingly used to treat patients with advanced hematologic malignancies; however, the symptoms related standard of care CAR during first year after treatment have not been assessed using patient-reported outcome (PRO) measurements. This study aimed quantify patients' perspectives symptom burden and functional status PROs for malignancies, especially in who experienced grade 2-4 toxicities. Sixty were enrolled this observational...
Purpose Recent data suggest that imaging radiomic features of a tumor could be indicative important genomic biomarkers. Understanding the relationship between and is for basic cancer research future patient care. We performed comprehensive study to discover imaginggenomic associations in head neck squamous cell carcinoma (HNSCC) explore potential predicting alternations using features. Methods Our retrospective integrated whole-genome multiomics from The Cancer Genome Atlas with matched...
Abstract Second primary malignancy (SPM) may occur after index head and neck cancer (HNC) treatment. This study evaluated the prevalence outcome of SPM in patients with HNC treated definitive radiotherapy. Eligible include those mucosal radiotherapy between 2000 2010. was defined as an invasive at a noncontiguous site diagnosed least 6 months completion Clinical data were collected, Kaplan–Meier method used to estimate overall survival. In total, 1512 studied. The majority had oropharyngeal...
K/MnOx catalysts on MnO2 and Fe3O4 supports were synthesized compared for the deep oxidation of cyclohexane. The presence potassium (K) enhanced catalytic activity to with similar composition but without K. Interestingly, lowest loading used in this study (0.63 mmoles/g support) performed better than those higher loadings. K increased water adsorption, decreased extent sintering, inhibited changes crystal phase catalyst support, as evidenced by TGA, XRD, BET surface area analyses. XRD...
Background: Breast cancer is the most common in Egyptian females. Most patients present at a late stage with subsequent poor outcomes. Aim: To study awareness of breast cancer, its risk factors and screening. investigate impact caring for family member on future attitudes caregivers. Methods: The included 704 females divided into two groups. A non-caregivers group including 248 participants representing general population caregivers 456 patients. We used questionnaire comprised 45 questions...
Abstract Incidental pulmonary embolisms (IPEs) are common in cancer patients. Examining the characteristics and outcomes of IPEs patients can help to ensure proper management, promoting better outcomes. To determine clinical characteristics, for patients, we conducted a 1:2 ratio case-control study identified all consecutive with IPE who visited emergency department at The University Texas MD Anderson Cancer Center between 1 January 2006 2016. Each case was matched 2 controls using...
We aim to determine the feasibility and dosimetric benefits of a novel MRI-guided IMRT dose-adaption strategy for human papillomavirus positive (HPV+) oropharyngeal squamous cell carcinoma (OPC).Patients with locally advanced HPV+ OPC underwent pre-treatment in-treatment MRIs every two weeks using RT immobilization setup. For each patient, plans were created (i.e. standard adaptive). The prescription dose was 2.12 Gy/fx 33 fractions initial PTV. adaptive plans, new PTVadaptive generated...
Background The current study was performed to assess the efficacy of surveillance imaging in patients with head and neck cancer (HNC) who are treated definitively radiotherapy. Methods Eligible included those a demonstrable disease‐free interval (≥1 follow‐up procedure without evidence disease subsequent visit/imaging procedure) underwent treatment HNC from 2000 through 2010. Results A total 1508 were included. median overall survival 99 months, period 59 months. Of patients, 190 (12.6%)...
We sought to model chronic radiation-associated dysphagia (RAD) in patients given intensity-modulated radiation therapy (IMRT) for oropharyngeal squamous cell cancer (OPSCC) as a function of age and dose non-target swallowing muscles.We reviewed 300 with T1-T4 N0-3 M0 OPSCC definitive IMRT concurrent chemotherapy. Chronic RAD was defined aspiration or stricture on videoflouroscopy/endoscopy, gastrostomy tube, pneumonia at ≥12 months after IMRT. Doses autosegmented regions interest (ROIs;...
MRI-guided radiotherapy planning (MRIgRT) may be superior to CT-guided in some instances owing its improved soft tissue contrast. However, MR images do not communicate electron density information necessary for dose calculation and therefore must either co-registered CT or algorithmically converted synthetic CT. No robust quality assessment of commercially available MR-CT registration algorithms is yet available; thus we sought quantify formally.Head neck non-contrast T2 MRI scans acquired...
Summary This cross‐sectional study aimed to develop and validate a patient‐reported outcomes (PROs) assessment tool assess symptom burden daily functioning in patients after chimeric antigen receptor (CAR) T‐cell therapy, the MD Anderson Symptom Inventory (MDASI‐CAR). The items were generated based on literature review, content elicitation interviews with patients, clinician's review. completed MDASI core module, single‐item quality‐of‐life (QoL) measure Patient‐Reported Outcomes Measurement...