A5020795619- Head and Neck Cancer Studies
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Colorectal and Anal Carcinomas
- Oral health in cancer treatment
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Lung Cancer Research Studies
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Advanced NMR Techniques and Applications
- Esophageal Cancer Research and Treatment
- Cancer Diagnosis and Treatment
- interferon and immune responses
- Metabolism, Diabetes, and Cancer
- Voice and Speech Disorders
- Cancer-related gene regulation
- Head and Neck Surgical Oncology
- Medical Imaging Techniques and Applications
- Cancer-related molecular mechanisms research
- Reconstructive Surgery and Microvascular Techniques
Baylor College of Medicine
2016-2025
Michael E. DeBakey VA Medical Center
2018-2025
The University of Texas MD Anderson Cancer Center
2011-2023
The Wallace H. Coulter Department of Biomedical Engineering
2023
Georgia Institute of Technology
2023
Princess Margaret Cancer Centre
2019
Albert Einstein College of Medicine
2016
Montefiore Medical Center
2016
Molecular Oncology (United States)
2012
The University of Texas Southwestern Medical Center
2011
Laryngotracheal stenosis (LTS) is largely considered a structural entity, defined on anatomic terms (i.e., percent stenosis, distance from vocal folds, overall length). This has significant implications for identifying at-risk populations, devising systems-based preventive strategies, and promoting patient-centered treatment. The present study was undertaken to test the hypothesis that LTS heterogeneous with regard etiology, natural history, clinical outcome.Retrospective cohort of...
Mortality of patients with head and neck squamous cell carcinoma (HNSCC) is primarily driven by tumor radioresistance leading to locoregional recurrence (LRR). In this study, we use a classification TP53 mutation (disruptive vs. nondisruptive) examine impact on clinical outcomes radiation sensitivity.Seventy-four HNSCC treated surgery postoperative 38 lines were assembled; for each, was sequenced the in vitro measured using clonogenic assays. p53 protein expression inhibited short hairpin...
Abstract BACKGROUND: Tumor metabolism is an essential contributor to disease progression and response treatment. An understanding of the metabolic phenotype head neck squamous cell carcinoma (HNSCC) will allow development appropriate antimetabolic strategies for this tumor type. METHODS: A panel 15 HNSCC lines was assayed glucose glutamine dependence sensitivity inhibitors. In addition, broad‐spectrum metabolomic analysis using mass spectrometry/liquid chromatography combined with individual...
Background: Anaplastic thyroid cancer (ATC) is one of the most lethal forms with a high mortality rate. Current guidelines support surgery for resectable ATC followed by external beam radiation therapy (EBRT) or without chemotherapy. Treatment those who are unresectable palliative. Our goal was to examine first-line therapies as well role genomic profiling in an effort better understand how approach ATC. Methods: This retrospective study patients were seen at our institution from January...
No single cancer immunotherapy will likely defeat all evasion mechanisms of solid tumors, including plasticity tumor antigen expression and active immune suppression by the environment. In this study, we increase breadth, potency, duration anti-tumor activity chimeric receptor (CAR) T cells using an oncolytic virus (OV) that produces cytokine, checkpoint blockade, a bispecific tumor-targeted cell engager (BiTE) molecule. First, constructed BiTE molecule specific for CD44 variant 6 (CD44v6),...
Cisplatin is commonly utilized in the treatment of solid tumors. Its mechanism action complex and multiple mechanisms resistance have been described. We sought to determine impact cisplatin-generated oxidative stress on head neck squamous cell carcinoma (HNSCC) proliferation, survival metabolic activity order identify a potential signature associated with cisplatin response. DNA-bound represents small fraction total intra-cellular but generates robust Neutralization reverses toxicity...
Background. We investigated the radiographic and pathologic response rate of esophageal adenocarcinoma treated with neoadjuvant chemoradiation in patients taking metformin. Material methods. Two hundred eighty-five concurrent (CRT) followed by esophagectomy from 1997 to 2012 were included study, including 29 diabetics metformin, 21 not metformin 235 non-diabetics. Pre- post-treatment positron emission tomography (PET) scans available for 204 patients. Pathologic was graded at time surgery....
Abstract Despite therapeutic advancements, oral cavity squamous cell carcinoma (OCSCC) remains a difficult disease to treat. Systemic platinum-based chemotherapy often leads dose-limiting toxicity (DLT), affecting quality of life. PRV111 is nanotechnology-based system for local delivery cisplatin loaded chitosan particles, that penetrate tumor tissue and lymphatic channels while avoiding systemic circulation toxicity. Here we evaluate using animal models cancer, followed by clinical trial in...
Abstract Purpose: Cisplatin (CDDP)-based chemotherapy is a first-line treatment for patients with advanced head and neck squamous cell carcinomas (HNSCC), despite high rate of failures, acquired resistance, subsequent aggressive behavior. The purpose this study was to the mechanism CDDP resistance metastasis in HNSCC. We investigated role NRF2 pathway activation as driven event tumor progression Experimental Design: Human HNSCC lines that are highly resistant were generated. Clonogenic...
Importance For patients with head and neck squamous cell carcinoma (HNSCC), initiation of postoperative radiation therapy (PORT) within 6 weeks surgery is recommended by the National Comprehensive Cancer Network Guidelines Commission on Cancer. Although individual-level measures socioeconomic status are associated receipt timely, guideline-adherent PORT, role neighborhood-level disadvantage has not been examined. Objective To characterize association delays in receiving PORT. Design,...
To characterize tumor growth and metastatic potential in head neck squamous cell carcinoma (HNSCC) lines an orthotopic murine model of oral tongue cancer to correlate TP53 mutation status with these findings.Cells from each 48 HNSCC were orthotopically injected into the tongues nude mice. Tumor volume, cervical lymph node metastasis, mouse survival recorded. Direct sequencing gene Western blot analysis for p53 protein after induction 5-fluorouracil was conducted. Cell categorized as either...
Abstract Locally advanced rectal cancer is commonly treated with chemoradiation prior to total mesorectal excision ( TME ). Studies suggest that metformin may be an effective chemopreventive agent in this disease as well a possible adjunct current therapy. In study, we examined the effect of use on pathologic complete response pCR ) rates and outcomes cancer. The charts 482 patients locally adenocarcinoma from 1996 2009 were reviewed. Median radiation dose was 50.4 Gy (range 19.8–63)....
Hyperpolarized [1-(13)C]-pyruvate has shown tremendous promise as an agent for imaging tumor metabolism with unprecedented sensitivity and specificity. Imaging hyperpolarized substrates by magnetic resonance is unlike traditional MRI because signals are highly transient their spatial distribution varies continuously over observable lifetime. Therefore, new approaches needed to ensure optimal measurement under these circumstances. Constrained reconstruction algorithms can integrate prior...
Anaplastic thyroid carcinoma (ATC) is an aggressive disease that requires rapid diagnosis and multimodality treatment. Recent advances in targeted therapeutics have provided ATC patients with previously unavailable treatment options, which may improve clinical outcomes the coming years. Continued development of high-throughput next-generation sequencing provides clinicians unparalleled ability to characterize genomic background tumors order guide selection trial enrollment.Twenty-three...
The outcomes of patients with unresected anaplastic thyroid carcinoma (ATC) from the National Cancer Data Base (NCDB) were assessed, and potential correlations explored between radiation therapy (RT) dose overall survival (OS).The study cohort was comprised who underwent either no surgery or grossly incomplete resection. Correlates OS using univariate analysis multivariable (MVA).In total, 1288 analyzed. mean patient age 70.2 years, 59.7% women, 47.6% received neck RT. median 2.27 months,...
Abstract Treatment of head and neck squamous cell carcinoma, HNSCC, often requires multimodal therapy, including radiation therapy. The efficacy radiotherapy in controlling locoregional recurrence, the most frequent cause death from is critically important for patient survival. One potential biomarker to determine radioresistance TP53 whose alterations are predictive poor response. DNA-damaging reactive oxygen species (ROS) a by-product ionizing that lead activation p53, transcription p21...
Metformin is a commonly used antidiabetic medication which has demonstrated promise as an anticancer agent alone and in combination with conventional treatment regimens. There increasing evidence that metformin can also generate immunomodulatory effects solid tumors currently being investigated adjunct to immune checkpoint inhibitors (ICIs). We hypothesized would shift immunity unfavorable tumor growth tested this hypothesis preclinical model of head neck cancer.Using syngeneic mouse human...
Abstract Background Human papillomavirus (HPV)–associated oropharyngeal squamous cell carcinoma (OPSCC) has excellent control rates compared to nonvirally associated OPSCC. Multiple trials are actively testing whether de-escalation of treatment intensity for these patients can maintain oncologic equipoise while reducing treatment-related toxicity. We have developed OP-TIL, a biomarker that characterizes the spatial interplay between tumor-infiltrating lymphocytes (TILs) and surrounding cells...
Background The existence of immunologically ‘cold tumors’ frequently found across a wide spectrum tumor types represents significant challenge for cancer immunotherapy. Cold tumors have poor baseline pan-leukocyte infiltration, including low prevalence cytotoxic lymphocytes, and not surprisingly respond unfavorably to immune checkpoint (IC) inhibitors. We hypothesized that cold harbor mechanism escape upstream independent ICs may be driven by biology rather than differences in mutational...
ABSTRACT Keloid formation has been linked to aberrant fibroblast activity, exacerbated by growth factors and inflammatory mediators. Prostaglandin E2 (PGE2), synthesized from arachidonic acid cyclooxygenases (COX) synthases (PGES), acts as both an mediator modulator. Although PGE2 known antifibrotic effects in the lower airway, its role dermal fibrosis general, keloid particular, remains unclear. This study focused on: (1) of on migration, contraction, collagen synthesis (2) endogenous...
Metformin use has been linked to improved cancer outcomes. The purpose of this study was determine the impact metformin on survival patients with laryngeal cancer.We retrospectively reviewed 205 a diagnosis squamous cell carcinoma (SCC).Patients taking presented more early-stage tumors (T1 and T2) less regional metastasis (N0; 81% metformin+ vs 50% metformin-) compared diabetes not metformin. At last follow-up, 76% were alive, 41% for diabetics 51% nondiabetics. users demonstrated increased...