A5079532080- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Traumatic Brain Injury and Neurovascular Disturbances
- Pituitary Gland Disorders and Treatments
- Head and Neck Surgical Oncology
- Brain Metastases and Treatment
- Neurosurgical Procedures and Complications
- Advanced Radiotherapy Techniques
- History of Medical Practice
- Vascular Malformations Diagnosis and Treatment
- Trigeminal Neuralgia and Treatments
- Management of metastatic bone disease
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Diversity and Career in Medicine
- Endometrial and Cervical Cancer Treatments
- Medical History and Innovations
- Neurofibromatosis and Schwannoma Cases
- Colorectal and Anal Carcinomas
- Ophthalmology and Eye Disorders
- Cancer, Hypoxia, and Metabolism
- Intracerebral and Subarachnoid Hemorrhage Research
- Surgical Simulation and Training
- Anatomy and Medical Technology
- Trauma and Emergency Care Studies
Vanderbilt University Medical Center
2016-2025
Neurological Surgery
2015-2024
Thomas Jefferson University Hospital
2023-2024
Thomas Jefferson University
2023-2024
Vanderbilt University
2014-2024
Orlando Health
2014-2024
Monroe Carell Jr. Children's Hospital
2021
University of Florida Health
2014-2020
UF Health Cancer Center
2014-2020
Allen Institute
2018
Antiangiogenic agents have recently shown impressive radiological responses in high-grade glioma. However, it is not clear if the are related to vascular changes or due antitumoral effects. The authors report mature results of a clinical study bevacizumab-based treatment recurrent gliomas.Sixty-one patients with gliomas received bevacizumab at 10 mg/ kg every 2 weeks for 4 doses an 8-week cycle along either irinotecan carboplatin. choice concomitant chemotherapeutic agent was based on number...
Abstract BACKGROUND: Anorectal melanoma is a rare disease with poor prognosis. Because survival determined by distant failure, many centers have adopted sphincter‐sparing excision for primary tumor control. However, this approach associated high rates of local failure (∼50%). In study, the authors report their 20‐year experience combined radiation therapy (RT) treatment localized anorectal melanoma. METHODS: The reviewed records 54 patients who were treated at University Texas MD Anderson...
Abstract Locally advanced rectal cancer is commonly treated with chemoradiation prior to total mesorectal excision ( TME ). Studies suggest that metformin may be an effective chemopreventive agent in this disease as well a possible adjunct current therapy. In study, we examined the effect of use on pathologic complete response pCR ) rates and outcomes cancer. The charts 482 patients locally adenocarcinoma from 1996 2009 were reviewed. Median radiation dose was 50.4 Gy (range 19.8–63)....
Abstract BACKGROUND Ventricular entry during glioblastoma resection and tumor contact with the subventricular zone (SVZ) have both been shown to associate development of hydrocephalus, leptomeningeal dissemination, distant parenchymal recurrence, decreased survival. However, prior studies did not analyze these variables together in a single-patient population; therefore, it is unknown which an independent predictor outcomes. OBJECTIVE To conduct comparative outcome analysis surgical...
Abstract Purpose: To review early outcomes for patients enrolled on our institution's protocol (PC01) with unresectable pancreatic cancer, and to test whether the serious adverse event rate could be reduced from 15% (expected) <5%. Patients Methods: Twelve were enrolled, but only 11 are reported in this analysis. Pathology all was reviewed at University of Florida Health Medical Center Jacksonville confirm diagnosis adenocarcinoma. Unresectability defined by radiographic evidence encasement...
Prototyping of cerebral vasculature models through stereolithographic methods have the ability to accurately depict 3D structures complicated aneurysms with high accuracy. We describe method manufacture such a model and review some its uses in context treatment planning, research, surgical training.We prospectively used data from rotational angiography 40-year-old female who presented an unruptured right paraclinoid aneurysm. The virtual was then converted physical life-sized model.The...
Patient Reported Outcome Measures (PROMs) quantify the patient's quality of life and symptom burden. This study assesses implementation an automated PROM-capture system in outpatient cranial neurosurgery clinic. We conducted both quantitative qualitative analyses a PROM tool single-center, dedicated brain tumor The primary measures were PROMIS-10 FACT-Br. outcome interest was completion. For analysis, patients providers queried over 6-month period to participate phone interview on their...
INTRODUCTION: Complications are an unfortunate, ubiquitous part of neurosurgery. METHODS: We surveyed 142 members the Congress Neurological Surgeons (CNS) to delineate array coping mechanisms adopted and magnitude impact that complications have on their wellbeing. RESULTS: Most respondents had resulted in death a patient (58.5%) even more short or long-term harm (80.3% 79.6%, respectively). significant (55.6%) profound (38.0%) emotional The most common healthy strategies were using errors as...
Primary CNS lymphoma was diagnosed in 13 patients after stereotaxic biopsy of indeterminate intracerebral mass lesions. Two also had laser extirpation CT-visible tumor. The group consisted 10 men and 3 women, aged 17 to 81 (mean, 55 years; median, 60 years). lesions on CT were characteristically hyperdense, homogenously contrast-enhancing, associated with mild moderate effect. Five more than one lesion visible CT. Complete staging procedures for occult systemic negative all patients....
Prophylaxis is increasingly prescribed in treatment of haemophilia and its benefit believed to be most significant for the youngest patients as haemophilic arthropathy may prevented if prophylaxis initiated prior recurrent haemarthroses. While clinical data are readily available A, analogous B relatively limited. A prospective study recombinant factor IX (BeneFIX; rFIX), designed allow investigator according customary practices, was conducted children <6 years old with severe B. Nearly all...
The effect of overloading and underloading on tissue ingrowth into the porous-coated titanium segmental prosthesis was studied in a canine femoral model. has modular components that are connected by conical coupling joint. One dog's hind legs immobilized suspended for three weeks using an external fixator to minimize loading prevent weight-bearing, while contralateral leg allowed bear weight freely, simulating situation. Five dogs reached final study period twelve without complication. There...
For many years the design of loop type directional couplers has relied heavily on experiment. One most common varieties been coupler much shorter than a wavelength and having built-in termination (vestigial arm). In this paper criteria for any length are considered, their application to either coaxial line or waveguide discussed. The theoretical basis is established by first considering theory coupled transmission lines. Several designs which utilize quarter-wavelength loops have very...