A5082668053- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Pancreatic and Hepatic Oncology Research
- Metastasis and carcinoma case studies
- Advanced Radiotherapy Techniques
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal Tumor Research and Treatment
- Advances in Oncology and Radiotherapy
- Colorectal Cancer Treatments and Studies
- Clinical practice guidelines implementation
- Esophageal Cancer Research and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Screening and Detection
- Cancer Genomics and Diagnostics
- Cervical Cancer and HPV Research
- Neuroendocrine Tumor Research Advances
- Renal cell carcinoma treatment
- Cancer Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Management of metastatic bone disease
- Anorectal Disease Treatments and Outcomes
- Medical Imaging Techniques and Applications
- Multiple and Secondary Primary Cancers
The University of Texas MD Anderson Cancer Center
2016-2025
Northwestern University
2016-2024
University of Southern California
2016-2023
Radiation Oncology Associates
2012-2022
Scripps MD Anderson Cancer Center
2015-2021
The University of Texas Health Science Center at Houston
2021
Medway Maritime Hospital
2020
AbbVie (United States)
2019
Novartis (Switzerland)
2019
Merck Serono (Switzerland)
2019
Gastric cancer is the third leading cause of cancer-related deaths worldwide. Over 95% gastric cancers are adenocarcinomas, which typically classified based on anatomic location and histologic type. generally carries a poor prognosis because it often diagnosed at an advanced stage. Systemic therapy can provide palliation, improved survival, enhanced quality life in patients with locally or metastatic disease. The implementation biomarker testing, especially analysis HER2 status,...
Abstract Esophageal cancer is the sixth leading cause of cancer-related deaths worldwide. Squamous cell carcinoma most common histology in Eastern Europe and Asia, adenocarcinoma North America Western Europe. Surgery a major component treatment locally advanced resectable esophageal esophagogastric junction (EGJ) cancer, randomized trials have shown that addition preoperative chemoradiation or perioperative chemotherapy to surgery significantly improves survival. Targeted therapies including...
Gastric cancer is the fifth most frequently diagnosed and third leading cause of death from in world. Several advances have been made staging procedures, imaging techniques, treatment approaches. The NCCN Clinical Practice Guidelines Oncology (NCCN Guidelines) for Cancer provide an evidence- consensus-based approach management patients with gastric cancer. This manuscript discusses recommendations outlined staging, assessment HER2 overexpression, systemic therapy locally advanced or...
The NCCN Clinical Practice Guidelines in Oncology for Gastric Cancer provide evidence- and consensus-based recommendations a multidisciplinary approach the management of patients with gastric cancer. For resectable locoregional cancer, guidelines recommend gastrectomy D1+ or modified D2 lymph node dissection (performed by experienced surgeons high-volume centers). Postoperative chemoradiation is preferred option after complete resection T3-T4 tumors node-positive T1-T2 tumors. chemotherapy...
We conducted a phase II trial of preoperative gemcitabine and cisplatin chemotherapy in addition to chemoradiation (Gem-Cis-XRT) pancreaticoduodenectomy (PD) for patients with stage I/II pancreatic adenocarcinoma.Chemotherapy consisted (750 mg/m(2)) (30 given every 2 weeks four doses. Chemoradiation weekly infusions (400 combined radiation therapy Gy 10 fractions administered over weeks) delivered 5 days per week. Patients underwent restaging 4 6 after completion and, the absence disease...
Neoadjuvant chemoradiotherapy for rectal cancer is associated with improved local control and may result in complete tumor response. Associations between response disease following radical resection should be established before used to evaluate treatment strategies. The purpose of this study was assess compare oncologic outcomes the degree pathologic after chemoradiotherapy.All patients locally advanced (cT3-4 or cN+ by endorectal ultrasonography, computed tomography, magnetic resonance...
Esophageal cancer is the sixth most common cause of deaths worldwide. Adenocarcinoma more in North America and Western European countries, originating mostly lower third esophagus, which often involves esophagogastric junction (EGJ). Recent randomized trials have shown that addition preoperative chemoradiation or perioperative chemotherapy to surgery significantly improves survival patients with resectable cancer. Targeted therapies trastuzumab ramucirumab produced encouraging results...
Abstract BACKGROUND The objective of this study was to identify predictive factors for pathologic complete response and tumor downstaging after preoperative chemoradiation rectal cancer. METHODS Between 1989 2004, 562 patients with nonmetastatic adenocarcinoma received underwent mesorectal excision. median radiation dose 45 Gray (Gy) (range, 19.8–58.6 Gy), 77% concurrent infusional 5‐fluorouracil, 20% capecitabine, 3% other regimens. RESULTS Nineteen percent achieved a (CR), whereas had only...
Overview Upper gastrointestinal tract cancers originating in the esophagus, esophagogastric junction (EGJ), and stomach constitute a major health problem around world. An estimated 37,640 new cases of 25,070 deaths from upper occurred United States 2010.1 A dramatic shift location tumors has States.2,3 Changes hisNCCN
Standard therapies for localized inoperable intrahepatic cholangiocarcinoma (IHCC) are ineffective. Advances in radiotherapy (RT) techniques and image guidance have enabled ablative doses to be delivered large liver tumors. This study evaluated the effects of RT dose escalation treatment IHCC.Seventy-nine consecutive patients with IHCC were identified treated definitive from 2002 2014. At diagnosis, median tumor size was 7.9 cm (range, 2.2 17 cm). Seventy (89%) received systemic chemotherapy...
Purpose This phase II trial was designed to assess the efficacy and safety of cetuximab, gemcitabine, oxaliplatin followed by capecitabine, radiation therapy in locally advanced pancreatic cancer (LAPC). Patients Methods Treatment-naive eligible patients (n = 69) received intravenous gemcitabine (1,000 mg/m 2 ) (100 every weeks for four doses, (50.4 Gy gross tumor only) with concurrent capecitabine (825 twice daily on treatment days). Cetuximab (500 started day 1 chemotherapy continued...
Cancers originating in the esophagus or esophagogastric junction constitute a major global health problem. Esophageal cancers are histologically classified as squamous cell carcinoma (SCC) adenocarcinoma, which differ their etiology, pathology, tumor location, therapeutics, and prognosis. In contrast to esophageal usually affects lower esophagus, SCC is more likely localize at higher than tracheal bifurcation. Systemic therapy can provide palliation, improved survival, enhanced quality of...
Consensus abstract Background The management of primary rectal cancer beyond total mesorectal excision planes (PRC-bTME) and recurrent (RRC) is challenging. There global variation in standards no guidelines exist. To achieve cure most patients require extended, multivisceral, exenterative surgery, conventional planes. aim the Beyond TME Group was to consensus on definitions principles management, identify areas research priority. Methods Delphi methodology used consensus. consisted invited...
The current study was conducted to determine whether there were differences in outcome for patients with unresectable locally advanced pancreatic cancer (LAPC) who received treatment chemoradiation therapy (CR) versus induction chemotherapy followed by CR (CCR).Between December 1993 and July 2005, 323 consecutive LAPC treated at the authors' institution radiotherapy concurrent gemcitabine or fluoropyrimidine chemotherapy. Two hundred forty-seven as initial treatment, 76 a median of 2.5...
Abstract This study tested the effects of fluid‐induced shear on high density monolayer cultures adult articular chondrocytes. Fluid‐induced (1.6 Pa) was applied by cone viscometer to normal human and bovine chondrocytes for periods 24, 48, 72 hours. At 48 hours, caused individual elongate align tangential direction rotation. stimulated glycosaminoglycan synthesis 2‐fold (p < 0.05) increased length newly synthesized chains in In chondrocytes, hydrodynamic size proteoglycans also...
The articular cartilage of diarthrodial joints experiences a variety stresses, strains and pressures that result from normal activities daily living. In cartilage, the extracellular matrix exists as highly organized composite specialized macromolecules distributes loads at bony ends. chondrocyte response to mechanical loading is recognized an integral component in maintenance homeostasis. With inappropriate joint, occurs with traumatic injury, ligament instability, malalignment or excessive...
Consensus abstract Background The management of primary rectal cancer beyond total mesorectal excision planes (PRC-bTME) and recurrent (RRC) is challenging. There global variation in standards no guidelines exist. To achieve cure most patients require extended, multivisceral, exenterative surgery, conventional planes. aim the Beyond TME Group was to consensus on definitions principles management, identify areas research priority. Methods Delphi methodology used consensus. consisted invited...
To identify predictive factors for locoregional recurrence (LR), distant metastasis (DM), and overall survival (OS) in patients treated with chemoradiation surgery rectal cancer.Between 1989 2001, 470 cancer were preoperative (89%) or postoperative (11%) mesorectal excision. Median radiation dose was 45 Gy; 97% received concurrent infusional 5-fluorouracil, 65% adjuvant chemotherapy. follow-up interval 5.7 years.The 5-year rates of freedom from LR, DM, OS 90%, 79%, 80%, respectively. On...