A5014886949- RNA modifications and cancer
- Cancer-related gene regulation
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Epigenetics and DNA Methylation
- Esophageal and GI Pathology
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Transplantation: Methods and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Nerve Injury and Rehabilitation
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Hedgehog Signaling Pathway Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Myasthenia Gravis and Thymoma
- Tracheal and airway disorders
- Infectious Diseases and Mycology
- Dysphagia Assessment and Management
- Mechanical Circulatory Support Devices
- Ultrasound in Clinical Applications
- Synthesis and biological activity
The University of Texas Southwestern Medical Center
2015-2025
Southwestern Medical Center
2015-2023
Harold C. Simmons Comprehensive Cancer Center
2022-2023
Children's Medical Center
2017
Scott & White Memorial Hospital
2008-2015
Baylor Scott & White Health
2011-2015
Temple University
2015
Texas A&M University System
2013
Texas A&M Health Science Center
2008-2011
Cleveland Clinic
2005-2010
Gastric cancer is the third leading cause of cancer-related deaths worldwide. Over 95% gastric cancers are adenocarcinomas, which typically classified based on anatomic location and histologic type. generally carries a poor prognosis because it often diagnosed at an advanced stage. Systemic therapy can provide palliation, improved survival, enhanced quality life in patients with locally or metastatic disease. The implementation biomarker testing, especially analysis HER2 status,...
Cancers originating in the esophagus or esophagogastric junction constitute a major global health problem. Esophageal cancers are histologically classified as squamous cell carcinoma (SCC) adenocarcinoma, which differ their etiology, pathology, tumor location, therapeutics, and prognosis. In contrast to esophageal usually affects lower esophagus, SCC is more likely localize at higher than tracheal bifurcation. Systemic therapy can provide palliation, improved survival, enhanced quality of...
<h3>Importance</h3> Distant recurrence following preoperative chemoradiotherapy and resection in patients with gastroesophageal adenocarcinoma is common. Adjuvant chemotherapy may improve survival. <h3>Objective</h3> To compare adjuvant postoperative observation adenocarcinoma. <h3>Design, Setting, Participants</h3> Propensity score–matched analysis using the National Cancer Database. We included adult who received a diagnosis between 2006 2013 of clinical stage T1N1-3M0 or T2-4N0-3M0 distal...
ABSTRACT Background and Objectives The presence of lymph node metastases in patients with gastric gastroesophageal junction (GEJ) adenocarcinoma provides prognostic information guides treatment decisions. We sought to determine the sensitivity computed tomography (CT) imaging for clinical nodal staging resectable GEJ a size cut‐off optimize diagnostic accuracy. Methods performed retrospective review who underwent curative‐intent resection or at our institution between 2010 2023. reviewed CT...
Endopeptidase (EP) 24.15 cleaves the Tyr5-Gly6 bond of luteinizing hormone-releasing hormone (LHRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), and is primary LHRH degrading enzyme in pituitary hypothalamic membrane preparations. Potent specific inhibitors were used to identify enzymes involved vivo degradation LHRH. After i.c.v. administration LHRH, only about 1% peptide was recovered from brain after 1 hr. Concurrent N-[1-(RS)-carboxy-3-phenylpropyl]-Ala-Ala-Phe-p-aminobenzoate...
Background. The main cause of morbidity and mortality after lung transplantation (LT) is bronchiolitis obliterans syndrome (BOS). Anti-HLA antibodies development LT has been shown to play an important role in BOS pathogenesis. However, the nature non-HLA developed their pathogenesis have not determined. Methods. Sera from 16 BOS+ patients 11 BOS− were collected at 12, 24, 36, 48 months LT. class I II absorbed with pooled human platelets lymphoblastoid cell lines, respectively. Then, presence...
In the past 30 years, incidence of esophageal adenocarcinoma (EAC) has increased more rapidly than any other cancer in United States. The prevalence obesity and diabetes mellitus drastically as well. We explored potential association between obesity, mellitus, EAC. By means retrospective interrogation an administrative database from fiscal year 2005-2009, we identified two cohorts. cohort was defined patients with distal esophagus or gastric cardia. comparison contained gastroesophageal...
Abstract Hispanic/Latino patients have a higher incidence of gastric cancer and worse cancer-related outcomes compared with other backgrounds. Whether there is molecular basis for these disparities unknown, as very few been included in previous studies. To determine the genomic landscape patients, we performed whole-exome sequencing (WES) RNA on tumor samples from 57 patients; germline analysis was conducted 83 patients. The results were data Asian White published by Cancer Genome Atlas. had...
Double lumen endotracheal tubes (DLT) are commonly used to provide single lung ventilation during thoracic surgery. A fiberoptic bronchoscope (FOB) is typically confirm accurate DLT placement. Accounting for initial purchase, maintenance, repair and cleaning, the use of an FOB can cost as much $312 per procedure. The VivaSight (VS-DLT) incorporates a built-in camera, which aimed at reducing its associated costs. In this study, we compared rate when intubating using either VS-DLT or...
Epiphrenic diverticulum is a rare disease associated with distal esophageal obstruction and weakened muscularis propria. We have adhered to an operative strategy of excision (diverticulectomy), repair wall, relief functional mechanical obstruction. sought assess this pathophysiology-directed treatment strategy. From 1987 2005, 44 patients underwent surgery for epiphrenic diverticulum. Diverticulectomy, repair, was performed in 35 (80%) esophagectomy nine (10%). Outcome (symptoms, diet,...
Although a rare entity, chondrosarcoma is the most common malignant tumor of chest wall. Most patients present with an enlarging, painful anterior wall mass arising from costochondrosternal junction. CT scan intravenous contrast gold standard radiographic study for diagnosis and operative planning. Contrary to previous dictum, resection may be performed in appropriate surgical candidate based on imaging characteristics or image-guided percutaneous biopsy results; incisional rarely required....
Abstract Purpose: Itraconazole has been repurposed as an anticancer therapeutic agent for multiple malignancies. In preclinical models, itraconazole antiangiogenic properties and inhibits Hedgehog pathway activity. We performed a window-of-opportunity trial to determine the biologic effects of in human patients. Experimental Design: Patients with non–small cell lung cancer (NSCLC) who had planned surgical resection were administered 300 mg orally twice daily 10–14 days. underwent dynamic...
Complete thymectomy is a key component of the optimal treatment for myasthenia gravis. Unilateral, minimally invasive approaches are increasingly utilized with debate about laterality approach. A right-sided approach has wider field view, while left-sided accesses potentially more thymic tissue. We aimed to assess impact on perioperative and medium-term outcomes, identify predictors 'good outcome' using standard definitions.We performed multicentre review 123 patients who underwent gravis...
Epineurial scarring in peripheral nerve after injury inhibits normal axonal regeneration primarily due to fibroblast deposition of type I collagen. The transforming growth factor beta (TGF-beta) family is an important class signaling molecules that has been shown stimulate fibroblasts produce aim this study was design a prototypic therapeutic system which the neutralization TGF-beta crushed rat sciatic would decrease collagen formation. A total 45 experimental Lewis rats were used. Group 1...
Abstract Background Lenvatinib is a multitargeted tyrosine kinase inhibitor that being tested in combination with immune checkpoint inhibitors to treat advanced gastric cancer; however, little data exists regarding the efficacy of lenvatinib monotherapy. Patient-derived xenografts (PDX) are established by engrafting human tumors into immunodeficient mice. The generation PDXs may be hampered growth lymphomas. In this study, we compared use mice different degrees immunodeficiency establish...