A5071617413- MRI in cancer diagnosis
- Renal cell carcinoma treatment
- Radiomics and Machine Learning in Medical Imaging
- Renal and related cancers
- Radiation Dose and Imaging
- Prostate Cancer Diagnosis and Treatment
- Hip disorders and treatments
- Advanced X-ray and CT Imaging
- Orthopaedic implants and arthroplasty
- Maternal and fetal healthcare
- Pregnancy and preeclampsia studies
- Prostate Cancer Treatment and Research
- Peripheral Nerve Disorders
- Medical Imaging Techniques and Applications
- Cancer Genomics and Diagnostics
- Orthopedic Infections and Treatments
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Shoulder Injury and Treatment
- Total Knee Arthroplasty Outcomes
- Sarcoma Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Ultrasound in Clinical Applications
- Radiology practices and education
- Botulinum Toxin and Related Neurological Disorders
Southwestern Medical Center
2016-2025
The University of Texas Southwestern Medical Center
2016-2025
Southern Methodist University
2016-2025
Zunyi Medical University
2025
NYU Langone Health
2024
Thomas Jefferson University Hospital
2024
Hebei Medical University
2024
Second Hospital of Hebei Medical University
2024
Advanced Imaging Research (United States)
2016-2023
University of Pennsylvania
2023
Abstract Purpose: The heterodimeric transcription factor HIF-2 is arguably the most important driver of clear cell renal carcinoma (ccRCC). Although considered undruggable, structural analyses at University Texas Southwestern Medical Center (UTSW, Dallas, TX) identified a vulnerability in α subunit, which heterodimerizes with HIF1β, ultimately leading to development PT2385, first-in-class inhibitor. PT2385 was safe and active first-in-human phase I clinical trial patients extensively...
Artificial intelligence (AI) algorithms are prone to bias at multiple stages of model development, with potential for exacerbating health disparities. However, in imaging AI is a complex topic that encompasses coexisting definitions.
The detection of small renal masses is increasing with the use cross-sectional imaging, although many incidental lesions have negligible metastatic potential. Among malignant clear cell carcinoma most prevalent and aggressive subtype. A method to identify such histology would aid in risk stratification. Our goal was evaluate a likelihood scale for multiparametric magnetic resonance imaging diagnosis histology.We retrospectively reviewed records patients cT1a who underwent partial or radical...
Abstract Focused ultrasound combined with bubble-based agents serves as a non-invasive way to open the blood-brain barrier (BBB). Passive acoustic detection was well studied recently monitor emissions induced by bubbles under energy, but ability perform reliable BBB opening real-time feedback control algorithm has not been fully evaluated. This study focuses on characterizing of different types bubbles: Optison, Definity, and custom-made nanobubble. Their performance based evaluated both...
Purpose To assess the diagnostic performance and interreader agreement of a standardized algorithm in determining histologic type small (≤4 cm) renal masses (SRMs) with multiparametric magnetic resonance (MR) imaging. Materials Methods This single-center retrospective HIPAA-compliant institutional review board–approved study included 103 patients 109 SRMs resected between December 2011 July 2015. The requirement for informed consent was waived. Presurgical MR images were reviewed by seven...
To determine how to optimize the delivery of machine learning techniques in a clinical setting detect intracranial hemorrhage (ICH) on non-contrast-enhanced CT images radiologists improve workflow.In this study, commercially available algorithm that flags abnormal noncontrast examinations for ICH was implemented busy academic neuroradiology practice between September 2017 and March 2019. The introduced three phases: (a) as "pop-up" widget ancillary monitors, (b) marked examination reading...
In patients with acute pulmonary embolism (PE), timely intervention (e.g., initiation of anticoagulation) is critical for optimizing clinical outcomes.
The use of artificial intelligence in screening mammography was supported by patients primarily as a second reader, despite concerns about loss personal interaction, privacy, transparency, and bias.
Background The high operational cost of MRI limits its utility for hepatocellular carcinoma (HCC) screening. Abbreviated‐protocol dynamic contrast‐enhanced (aMRI) may help lower while maintaining the accuracy complete‐protocol diagnostic (cMRI). Purpose To compare aMRI to cMRI HCC detection in cirrhosis patients. Study Type Cross‐sectional study. Population Cirrhosis patients undergoing suspected HCC. Field Strength/Sequence 1.5T and 3T; (coronal T 2 ‐weighted, axial 1 ‐weighted...
Hip dysplasia (HD) leads to premature osteoarthritis. Timely detection and correction of HD has been shown improve pain, functional status, hip longevity. Several time-consuming radiological measurements are currently used confirm HD. An artificial intelligence (AI) software named HIPPO automatically locates anatomical landmarks on anteroposterior pelvis radiographs performs the needed measurements. The primary aim this study was assess reliability tool as compared multi-reader evaluation in...
Background Placenta accreta spectrum (PAS) in women with previous cesarean delivery has become increasingly prevalent. Depending on the severity, patient management may involve hysterectomy. Purpose To investigate textural analyses as radiomics MRI of placenta predicting PAS requiring hysterectomy a high‐risk population. Study Type Retrospective. Population Sixty‐two prior referred for because sonographic suspicion PAS. Field Strength/Sequence 1.5T T 1 W, 2 and diffusion‐weighted imaging...
Diagnostic Utility of a Likert Scale Versus Qualitative Descriptors and Length Capsular Contact for Determining Extraprostatic Tumor Extension at Multiparametric Prostate MRIDaniel N. Costa1,2, Niccolo M. Passoni3, John R. Leyendecker1, Alberto Diaz de Leon1, Yair Lotan3, Claus G. Roehrborn3, Susana Otero-Muinelo1, Harpreet Grewal1, Yin Xi1, Franto Francis4, Neil Rofsky1,2 Ivan Pedrosa1,2,3Audio Available | Share Claim CREDIT
When performing ultrasound (US) for hepatocellular carcinoma (HCC) screening, numerous factors may impair hepatic visualization, potentially lowering sensitivity. US LI-RADS includes a visualization score as technical adequacy measure.
To develop and evaluate domain-specific pretrained bidirectional encoder representations from transformers (BERT) models in a transfer learning task on varying training dataset sizes to annotate larger overall dataset.The authors retrospectively reviewed 69 095 anonymized adult chest radiograph reports (reports dated April 2020-March 2021). From the cohort, 1004 were randomly selected labeled for presence or absence of each following devices: endotracheal tube (ETT), enterogastric (NGT,...
Abstract Treatment of prosthetic joint infection (PJI) usually requires surgical replacement the infected and weeks antibiotic therapy, due to formation biofilm. We introduce a non-invasive method for thermal destruction biofilm on metallic implants using high-frequency (>100 kHz) alternating magnetic fields (AMF). In vitro investigations demonstrate >5-log reduction in bacterial counts after 5 minutes AMF exposure. Confocal scanning electron microscopy confirm removal matrix...