A5050692082- Pelvic floor disorders treatments
- Anorectal Disease Treatments and Outcomes
- Diverticular Disease and Complications
- Hepatocellular Carcinoma Treatment and Prognosis
- Pelvic and Acetabular Injuries
- MRI in cancer diagnosis
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Renal cell carcinoma treatment
- Colorectal Cancer Surgical Treatments
- Hernia repair and management
- Urological Disorders and Treatments
- Urinary Bladder and Prostate Research
- Liver Disease and Transplantation
- Urinary Tract Infections Management
- Renal and related cancers
- Colorectal Cancer Screening and Detection
- Radiation Dose and Imaging
- Pancreatitis Pathology and Treatment
- Colorectal and Anal Carcinomas
- Urologic and reproductive health conditions
- Circular RNAs in diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
The University of Texas Southwestern Medical Center
2016-2025
Southwestern Medical Center
2015-2025
North Carolina State University
2024
Hôpital Paris Saint-Joseph
2023
University of Zurich
2023
Medanta The Medicity
2021
Medanta The Medicity
2021
Cleveland Clinic
2020
Vanderbilt University Medical Center
2019
Advanced Imaging Research (United States)
2017-2018
Background Abbreviated MRI is a proposed paradigm shift for hepatocellular carcinoma (HCC) surveillance, but data on its performance are lacking histopathologically confirmed early-stage HCC. Purpose To evaluate the sensitivity and specificity of dynamic contrast-enhanced abbreviated HCC detection, using surgical pathologic findings as reference standard. Materials Methods This retrospective study was conducted at three U.S. liver transplant centers in patients with cirrhosis who underwent...
BTG3 / ANA APRO4 has been reported to be a tumor suppressor gene in some malignancies. It constitutes important negative regulatory mechanism for Src-mediated signaling, regulator of the cell cycle and inhibits transcription factor E2F1. We report that is downregulated renal cancer inactivation through promoter hypermethylation. Quantitative real-time polymerase chain reaction (PCR) showed was tissues cells. Genistein 5-aza-2′-deoxycytidine (5Aza-C) induced messenger RNA (mRNA) expression...
Abstract Purpose: To evaluate apparent diffusion coefficient (ADC) values for characterization of a variety focal liver lesions and specifically differentiation solid benign (focal nodular hyperplasia [FNH] adenomas) from malignant neoplasms (metastases hepatocellular carcinoma [HCC]) in large case series. Materials Methods: A total 542 382 patients were evaluated. ADC measured 166 hemangiomas, 112 hepatomas, 107 metastases, 95 cysts, 10 abscesses, 43 FNH, nine adenomas. ADCs 1.5 1.6 (×10 −3...
MicroRNAs (miRNAs) are small noncoding RNAs that have important roles in numerous cellular processes. Recent studies shown aberrant expression of miRNAs prostate cancer tissues and cell lines. On the basis miRNA microarray data, we found miR-145 is significantly downregulated cancer. We investigated functional significance The was low all lines tested (PC3, LNCaP DU145) compared with normal line, PWR-1E, cancerous regions human tissue when matched adjacent normal. Overexpression...
Background and Aims There are limited data on hepatocellular carcinoma (HCC) growth patterns, particularly in Western cohorts, despite implications for surveillance, prognosis, treatment. Our study’s aim was to quantify tumor doubling time (TDT) identify correlates associated with indolent rapid growth. Approach Results We performed a retrospective multicenter cohort study of patients cirrhosis diagnosed HCC from 2008 2017 at six US European health systems two or more contrast‐enhanced...
The detection of small renal masses is increasing with the use cross-sectional imaging, although many incidental lesions have negligible metastatic potential. Among malignant clear cell carcinoma most prevalent and aggressive subtype. A method to identify such histology would aid in risk stratification. Our goal was evaluate a likelihood scale for multiparametric magnetic resonance imaging diagnosis histology.We retrospectively reviewed records patients cT1a who underwent partial or radical...
Purpose To assess the diagnostic performance and interreader agreement of a standardized algorithm in determining histologic type small (≤4 cm) renal masses (SRMs) with multiparametric magnetic resonance (MR) imaging. Materials Methods This single-center retrospective HIPAA-compliant institutional review board–approved study included 103 patients 109 SRMs resected between December 2011 July 2015. The requirement for informed consent was waived. Presurgical MR images were reviewed by seven...
The functional significance of Wnt antagonist DKK1 has not been investigated in renal cell carcinoma (RCC). Therefore, we hypothesized that may be a tumor suppressor gene and is epigenetically silenced, thus decreased cause progression RCC. To assess the function DKK1, established stable transfected cells monitored them regarding viability, colony formation, apoptosis, cycle, invasive capability. RCC lines had levels which were increased after treatment with 5-Aza-2'-deoxycytidine...
Background The high operational cost of MRI limits its utility for hepatocellular carcinoma (HCC) screening. Abbreviated‐protocol dynamic contrast‐enhanced (aMRI) may help lower while maintaining the accuracy complete‐protocol diagnostic (cMRI). Purpose To compare aMRI to cMRI HCC detection in cirrhosis patients. Study Type Cross‐sectional study. Population Cirrhosis patients undergoing suspected HCC. Field Strength/Sequence 1.5T and 3T; (coronal T 2 ‐weighted, axial 1 ‐weighted...
Standardization of MRI Screening and Reporting in Individuals With Elevated Risk Pancreatic Ductal Adenocarcinoma: Consensus Statement the PRECEDE ConsortiumChenchan Huang, MD1, Diane M. Simeone, MD2, Lyndon Luk, MD3, Elizabeth Hecht, MD4, Gaurav Khatri, MD5, Avinash Kambadakone, MBBS, MD, DNB6, Hersh Chandarana, Justin Ream, MD7, Jessica N. Everett, MS2, Alexander Guimaraes, PhD8, Joy Liau, PhD9, Anil K. Dasyam, MD10, Carla Harmath, MD11, Alec J. Megibow, MPH1 for ConsortiumAudio Available...