A5051071188- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Tumor Research and Treatment
- Neuroendocrine Tumor Research Advances
- Epigenetics and DNA Methylation
- Cell Adhesion Molecules Research
- Cancer, Hypoxia, and Metabolism
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Surgical Treatments
- Sarcoma Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac tumors and thrombi
- Neuroblastoma Research and Treatments
- Colorectal and Anal Carcinomas
- Cutaneous Melanoma Detection and Management
- Ubiquitin and proteasome pathways
- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
Mount Sinai Medical Center
2016-2025
Roswell Park Comprehensive Cancer Center
2014-2023
Advanced Materials Enterprises (China)
2021
Lanzhou University
2021
Penn State Milton S. Hershey Medical Center
2020
Jacobi Medical Center
2019
American College of Surgeons
2009-2016
Florida College
2005-2015
University of Florida
2005-2015
Buffalo State University
2012
Gastric cancer is the third leading cause of cancer-related deaths worldwide. Over 95% gastric cancers are adenocarcinomas, which typically classified based on anatomic location and histologic type. generally carries a poor prognosis because it often diagnosed at an advanced stage. Systemic therapy can provide palliation, improved survival, enhanced quality life in patients with locally or metastatic disease. The implementation biomarker testing, especially analysis HER2 status,...
Abstract Esophageal cancer is the sixth leading cause of cancer-related deaths worldwide. Squamous cell carcinoma most common histology in Eastern Europe and Asia, adenocarcinoma North America Western Europe. Surgery a major component treatment locally advanced resectable esophageal esophagogastric junction (EGJ) cancer, randomized trials have shown that addition preoperative chemoradiation or perioperative chemotherapy to surgery significantly improves survival. Targeted therapies including...
Gastric cancer is the fifth most frequently diagnosed and third leading cause of death from in world. Several advances have been made staging procedures, imaging techniques, treatment approaches. The NCCN Clinical Practice Guidelines Oncology (NCCN Guidelines) for Cancer provide an evidence- consensus-based approach management patients with gastric cancer. This manuscript discusses recommendations outlined staging, assessment HER2 overexpression, systemic therapy locally advanced or...
Esophageal cancer is the sixth most common cause of deaths worldwide. Adenocarcinoma more in North America and Western European countries, originating mostly lower third esophagus, which often involves esophagogastric junction (EGJ). Recent randomized trials have shown that addition preoperative chemoradiation or perioperative chemotherapy to surgery significantly improves survival patients with resectable cancer. Targeted therapies trastuzumab ramucirumab produced encouraging results...
Objective To examine the authors' experience with preoperative ipsilateral portal vein embolization (PVE) and assess its role in extended hepatectomy. Summary Background Data Extended hepatectomy (five or more liver segments) has been associated higher complication rates increased postoperative dysfunction than have standard hepatic resections involving lesser volumes. Recently, PVE used patients who a predicted (postresection) future remnant (FLR) volume less 25% of total an attempt to...
In some organs (eg, the lung), endocrine tumors are classified on basis of mitotic rate and necrosis. The purpose this study was to evaluate prognostic factors in pancreatic neoplasms recently treated at a single institution.In 136 patients undergoing surgery from 1979 1998, influence disease-free survival (DFS) disease-specific (DSS) tumor size, rate, vascular invasion, necrosis, metastases, nuclear grade determined. Cases were further grouped according an existing proposed classification...
Objective The purpose of the study was to determine whether early postoperative enteral feeding with an immune-enhancing formula (IEF) decreases morbidity, mortality, and length hospital stay in patients upper gastrointestinal (GI) cancer. Summary Background Data Early IEF has been associated improved outcome trauma critical care patients. Evaluable data documenting reduced complications after major GI surgery for malignancy are limited. Methods Between March 1994 August 1996, 195 a...
The indications for preoperative biliary stenting in patients with obstructive jaundice are controversial. We evaluated the effect of on bacterobilia and infectious complications following surgical treatment proximal cholangiocarcinoma.A retrospective review was performed all undergoing metropolitan cancer surgery service.Seventy-one underwent palliative bypass or curative resection cholangiocarcinoma from March 1, 1991, to April 1997, were entered into a prospective database. Forty-one...
Purpose The WHO classification for well-differentiated pancreatic endocrine neoplasms (PENs) incorporates both stage and grade. This study compares the prognostic value of a simplified staging grading system with in large single-institution study. Patients Methods A prospective database (1982 to 2005) identified 183 patients who underwent operative treatment PENs. Tumors were staged (< 2 cm primary, ≥ or metastases) graded (low grade: no necrosis < two mitoses/50 high-powered fields...
Failure to rescue (FTR), or death after a potentially preventable complication, is nationally endorsed, publicly reported quality measure. However, little known about the impact of frailty on FTR, in particular low-risk surgical procedures.To assess association with FTR patients undergoing inpatient surgery.This study assessed cohort 984 550 general, vascular, thoracic, cardiac, and orthopedic surgery National Surgical Quality Improvement Program between January 1, 2005, December 31, 2012....
Focal adhesion kinase (FAK) is a cytoplasmic tyrosine that overexpressed in many types of tumors, including pancreatic cancer, and plays an important role cell survival signaling. Pancreatic cancer lethal disease very resistant to chemotherapy, FAK has been shown recently assist tumor survival. Therefore, excellent potential target for anti-cancer therapy. We identified novel small molecule inhibitor (1,2,4,5-Benzenetetraamine tetrahydrochloride, we called Y15) targeting the main...
We conducted a meta-analysis to evaluate the efficacy of anti-programmed cell death 1 (PD-1)/programmed ligand (PD-L1) monotherapy or immunotherapy combined with chemotherapy and further estimated value PD-L1 expression in predicting response from anti-PD-1/PD-L1 treatments as combination chemotherapy.Clinical trial data were searched electronic databases, which evaluated PD-1/PD-L1 inhibitors non-small lung cancer (NSCLC) correlated levels.Fifteen randomized-controlled trials involving...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is known for its hypovascularity. Bevacizumab, an anti-angiogenic drug, added to standard chemotherapy demonstrated no improvement in outcome PDAC. Therefore, we hypothesized that increased vascularity may be associated with improved outcomes PDAC possibly due better delivery of tumor specific immune cells. To test this hypothesis, patients were classified into either high or low CD31 expression groups utilizing mRNA from RNA-sequence data The...
A preoperative biliary stent is commonly used after the initial evaluation of patient with a periampullary mass.To evaluate effect on operative difficulty, postoperative complications, and length hospital stay pancreatoduodenectomy.A retrospective review prospectively collected consecutive series.The Memorial Sloan-Kettering Cancer Center's Surgical Service, New York, NY.Seventy-four patients underwent pancreatoduodenectomy between March 1, 1994, February 15, 1996. Thirty-five did not...
To determine the utility of MRI for assessing axillary lymph node status in patients with breast cancer.A consecutive series who underwent MR before surgical management cancer sampling between 2005 and 2007 were identified. MRs evaluated number nodes, contrast kinetics, nodal area, nodes no fatty hilum. Data analyzed context final pathology, sentinel status, status. Correlations using Kendall's tau-b test. Reported P values are one-sided.Fifty-six females (median = 58 years) studied....
Esophageal cancer in the United States carries a poor prognosis with overall 5 year survival rate of approximately 10%. Due to this dismal outcome, data analyzing factors predictive for greater than years are not available.Single institution retrospective review esophageal resection curative intent from 1984 2004. We identified 50 actual survivors (long term survivors, LTS) out 266 patients (19%) invasive and, using multivariate logistic regression, compared characteristics between LTS, and...