A5063210126- Superconducting Materials and Applications
- Particle accelerators and beam dynamics
- Physics of Superconductivity and Magnetism
- Superconductivity in MgB2 and Alloys
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Advanced Photocatalysis Techniques
- Postharvest Quality and Shelf Life Management
- Fusion materials and technologies
- Dialysis and Renal Disease Management
- Epigenetics and DNA Methylation
- Plant-Microbe Interactions and Immunity
- Breast Cancer Treatment Studies
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Complement system in diseases
- Electronic Packaging and Soldering Technologies
- Nanoplatforms for cancer theranostics
- Electric Motor Design and Analysis
- Fungal and yeast genetics research
- Blood groups and transfusion
- Phytochemistry and biological activities of Ficus species
- Nanocomposite Films for Food Packaging
- Tuberculosis Research and Epidemiology
Lanzhou University
2025
Chongqing Normal University
2021-2025
Shenyang University of Technology
2024
Hyper Tech Research (United States)
2015-2024
TU Dresden
2024
American Academy of Ophthalmology
2023-2024
Helmholtz-Zentrum Dresden-Rossendorf
2024
University Hospital Carl Gustav Carus
2024
Anhui University of Traditional Chinese Medicine
2024
Merck & Co., Inc., Rahway, NJ, USA (United States)
2022-2024
Abstract Pancreatic ductal adenocarcinoma (PDAC) is known for its hypovascularity. Bevacizumab, an anti-angiogenic drug, added to standard chemotherapy demonstrated no improvement in outcome PDAC. Therefore, we hypothesized that increased vascularity may be associated with improved outcomes PDAC possibly due better delivery of tumor specific immune cells. To test this hypothesis, patients were classified into either high or low CD31 expression groups utilizing mRNA from RNA-sequence data The...
Abstract Excessive mitochondrial fission acts as a pro-proliferative marker in some cancers and organ fibrosis; its potential role renal fibroblast activation fibrogenesis has never been investigated. Here, we showed more pronounced fragmented mitochondria fibrotic than non-fibrotic humans mice. In mouse model of obstructive nephropathy, phosphorylation Drp1 at serine 616 (p-Drp1S616) acetylation H3K27(H3K27ac) was increased kidneys; pharmacological inhibition by mdivi-1 substantially...
Abstract Due to the loss of DNA repair mechanisms in colorectal cancer (CRC) with microsatellite instability (MSI), somatic mutations accumulate within DNA; making them more prone attack by tumor infiltrating lymphocytes (TIL) and macrophages. We hypothesize that MSI-High (MSI-H) patients have favorable survival due increased immunogenicity. The Cancer Genome Atlas (TCGA) was used evaluate gene expression from 283 CRC, comparing MSI-H stable (MSS) patients. CIBERSORT algorithm estimated...
Annexin A1 (ANXA1) is a phospholipid-linked protein involved in inflammation, immune response, and mast cell reactivity. Recently, we reported that ANXA1 associated with aggressive features of triple-negative breast cancer (TNBC); however, its clinical relevance remains controversial. We hypothesized human TNBC high expression mRNA pro-cancerous infiltration, including cells, an phenotype. Clinical RNA-seq data were obtained from The Cancer Genome Atlas (TCGA, n = 1079) Molecular Taxonomy...
Estrogen receptor (ER) positive breast cancer (BC), the most abundant BC subtype, is notorious for poor response to neoadjuvant chemotherapy (NAC). The androgen (AR) was reported support estradiol-mediated ER activity in an vitro system. Recently, ER-positive with fewer tumor infiltrating lymphocytes (TILs) shown have a better prognosis, opposite trend seen ER-negative BC. We hypothesized that high expression of AR will TILs and inferior NAC, but prognosis. In both TCGA METABRIC cohorts,...
Some microRNAs (miRNAs) are known to suppress breast cancer. However, whether the expressions of these tumor suppressive miRNAs translate patient survival were not investigated in large cohort. Nine (miR-30a, miR-30c, miR-31, miR-126, miR-140, miR-146b, miR-200c, miR-206, and miR-335) be cancer Genomic Data Common data portal miRNA-Seq dataset The Cancer Genome Atlas (TCGA) (n = 1052). Of 9 miRNAs, miR-30a, miR-335 found have significantly lower expression tissues compared paired normal...
7-demethoxytylophorine (DEM) is a phenanthroindolizidine alkaloid, which reported to be effective in inhibiting leucocytes and regulation of human immunity. However, few studies the inhibitory effect DEM against plant-pathogenic fungi, particularly postharvest pathogen Penicillium italicum (P. italicum). Current have investigated antifungal activity through membrane damage energy deficit P. italicum. The results showed that potentially inhibits growth dose-dependent manner. In vitro...
Nb3Sn strands fabricated using Nb–Zr alloy can be internally oxidized, provided that oxygen is properly supplied via an oxide powder. This allows the formation of fine intragranular and intergranular ZrO2 particles in a matrix. These refine grain size by factor three thereby greatly enhance critical current density.
Cytolytic activity score (CYT), defined by granzyme A and perforin expression, is a useful marker for underlying immunity. We hypothesized that CYT-high hepatocellular carcinomas (HCCs) have stronger immunogenicity favorable tumor microenvironments, which would result in better clinical outcomes, using the cancer genome atlas (TCGA) cohort with 371 patients HCC. found HCCs were associated higher expressions of apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3 (APOBEC3),...
Triple‑negative breast cancer (TNBC) cells form angiogenesis‑independent vessel‑like structures to survive, known as vasculogenic mimicry (VM), contributing a poor prognosis for patients. Nuclear localized class I histone deacetylases (HDACs) enzymes, particularly HDACs 1, 2, 3 deacetylate chromatin histones, are overexpressed in cancers and epigenetically regulate the expression of genes involved initiation progression. The specific HDAC inhibitor, entinostat, has been shown attenuate tumor...
The aim of the study was to investigate if there were differences in associations stromal versus intratumoral tumor infiltrating lymphocytes (TILs) with pathology complete response (pCR) among breast cancer (BC) subtypes treated neoadjuvant therapy.The hematoxylin and eosin slides BC-core biopsy consecutive cases (n=331) reviewed from a single institution between 2000 2014. TIL-stroma (TIL-str) scored 0% 100%. Intratumoral (iTu-Ly) semiquantitatively incorporating infiltrate grade (0 3)...
Conceptual designs of 1.5 and 3.0 T full-body magnetic resonance imaging (MRI) magnets using conduction cooled MgB
Solar-blind deep-ultraviolet communication (SDUC) presents a promising candidate for use in short-range military communications. photodetectors (PDs) form up the core component of SDUC system’s receiving signal. In this study, an easy-to-integrate metal-semiconductor-metal (MSM)-type solar-blind PD is successfully fabricated based on β-Ga 2 O 3 film deposited c-plane sapphire substrates by low-cost radio-frequency magnetron sputtering. The device exhibits high responsivity 1.93 A W −1 ,...