A5014178704- Cancer-related Molecular Pathways
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal Cancer Research and Treatment
- Cancer and Skin Lesions
- Congenital Diaphragmatic Hernia Studies
- Thyroid and Parathyroid Surgery
- Vascular Tumors and Angiosarcomas
- Diverticular Disease and Complications
- Head and Neck Anomalies
- Multiple and Secondary Primary Cancers
- vaccines and immunoinformatics approaches
- COVID-19 and healthcare impacts
- Intestinal and Peritoneal Adhesions
Mount Sinai Medical Center
2019-2023
Roswell Park Comprehensive Cancer Center
2017-2021
Sylvester Comprehensive Cancer Center
2019-2020
Consumer VOICE
2020
Kyoto Prefectural University of Medicine
2018
Johnson University
2014-2016
Rutgers, The State University of New Jersey
2013-2016
Robert Wood Johnson University Hospital
2015
Rutgers Cancer Institute of New Jersey
2013-2014
Whittington Hospital
2002
// Xin Yu 1,2,* , Adam R. Blanden 3,* Sumana Narayanan 2 Lalithapriya Jayakumar David Lubin 3 Augeri 4 S. Kimball Stewart N. Loh and Darren Carpizo 1,2 1 Rutgers Cancer Institute of New Jersey, Jersey Department Surgery, Robert Wood Johnson Medical School, Brunswick, Biochemistry Molecular Biology, SUNY Upstate University, Syracuse, York Medicinal Chemistry, Ernest Mario School Pharmacy, Piscataway, * These authors contributed equally to this work Correspondence: Loh, email: Carpizo,...
Abstract Due to the loss of DNA repair mechanisms in colorectal cancer (CRC) with microsatellite instability (MSI), somatic mutations accumulate within DNA; making them more prone attack by tumor infiltrating lymphocytes (TIL) and macrophages. We hypothesize that MSI-High (MSI-H) patients have favorable survival due increased immunogenicity. The Cancer Genome Atlas (TCGA) was used evaluate gene expression from 283 CRC, comparing MSI-H stable (MSS) patients. CIBERSORT algorithm estimated...
Background: The corona virus disease of 2019 (COVID-19) imposed new public health constraints that deterred people from coming to the hospital. outcome patients who developed appendicitis during mandated COVID-19 quarantine has yet be examined. main objective was establish whether there an increased rate perforated seen quarantine. Secondary objectives included observing type procedure performed, length stay, and associated complications.
microRNA-143 (miR-143) is a well-known tumor suppressive microRNA that exhibits anti-tumoral function by targeting KRAS signaling pathways in various malignancies. We hypothesized miR-143 suppresses breast cancer progression and its effector molecules. further high expression of associated with favorable immune microenvironment estrogen receptor (ER)-positive patients which result improved survival. Two major publicly available cohorts; The Cancer Genome Atlas (TCGA) Molecular Taxonomy...
Background and Objectives Surgical management of colorectal cancer liver metastases continues to evolve optimize oncologic outcomes while maximizing parenchymal preservation. Long‐term data after intraoperative microwave ablation are limited. This study investigates patterns recurrence in patients who underwent ablation. Methods A retrospective analysis 33 from 2009 2013 at our institution was performed. Perioperative long‐term were reviewed determine recurrence. Results total 49 tumors...
The purpose of this study was to characterize disparities among centers performing major surgery for esophageal or gastric cancer stratified by case volume.The National Cancer Data Base (NCDB) queried cases esophagectomy total gastrectomy. Centers were compared based on number during 2004-2013: low volume [1-99], middle [100-200], and high [>200].For esophagectomy, 17,547 patients included; 73.5% treated in centers, 14.6% middle, 11.9% high. For gastrectomy, 20,059 included, with 87.5%,...
The significance of green public spaces is well documented in relation to social inclusiveness, human health, and biodiversity, yet how achieve what Gough (2017) has termed ‘sustainable wellbeing’ less understood. This contribution presents preliminary results from a study four mega-cities South Southeast Asia: Chennai (Republic India), Metro Manila the Philippines), Singapore, Shanghai (People’s Republic China), cities that have climates ranging tropical, subtropical temperate. conceptual...
Laparoscopic and robotic hernia surgery offers advantages over open herniorrhaphy including faster recover lower wound infection but is associated with rare serious complications such as visceral injury intestinal obstruction. We describe two cases of small bowel obstruction strangulation that occurred shortly after routine surgery. define this type strangulating internal a peritoneal pocket call attention to its diagnosis management.
Background The purpose of this study was to determine whether neoadjuvant and/or perioperative chemotherapy (NAC) has an overall survival (OS) benefit for patients with T2N0 gastric adenocarcinoma. Study Design We performed retrospective analyses using the National Cancer Data Base, 2004‐2013. Patients adenocarcinoma were divided into two treatment groups: (1) NAC plus surgery (NA + S) and (2) alone (S). Results Of 1,704 included, 277 (16.3%) received NAC, 1,427 (83.7%) treated alone. in NA...
Molecular analysis has been performed on a Malaysian patient with severe bleeding disorder due to factor XIII A subunit deficiency. Total mRNA was isolated from the patient's leucocytes and four overlapping segments corresponding entire coding region of cDNA were amplified by RT‐PCR. The efficiently expected size. Direct sequencing complete reading frame revealed single homozygous base change (nt 1327G→T) in exon 10 missense mutation, Val414Phe, catalytic core domain monomer. mutation...
Pedestrian and cyclist safety are not considered by urban planners or road users in India. Data on crashes tend to underreport involving this group. In spite of adopting a Non-Motorised-Transport (NMT) friendly policy 2014, Chennai city Tamil Nadu continues prioritise motorised transport. Five years after the NMT Policy adoption, pedestrian infrastructure was assessed 11 locations. A perception survey 37 also conducted as calls for changing mindset motorists towards pedestrians. The...
Hidradenocarcinoma (HC) is a rare malignant sweat gland tumor with metastatic potential primarily located in the head, neck, and trunk. We present an unusual case of large lower extremity Clear Cell HC managed surgical resection adjuvant locoregional radiation after excluding lymph node involvement.
473 Background: Neoadjuvant chemotherapy is increasingly being utilized for locally advanced (LAPC)/borderline resectable pancreatic cancer (BRPC); however, long term follow up data sparse. At our institution, we use FOLFIRINOX as the regimen of choice. Gemcitabine (Gem) and nab-Paclitaxel (Abraxane) in patients not suited or if they have poor radiographic response and/or develop significant toxicities to FOLFIRINOX. The aim this study was report institutional experience with neoadjuvant...
Background: Follicular neoplasm (Bethesda IV cytology) requires thyroid lobectomy for diagnosis. Approximately 15-30% of cases are ultimately malignant, requiring reoperative completion thyroidectomy. We sought to reassess whether intraoperative frozen section (FS) reduces the need thyroidectomy in these cases. Methods: A retrospective chart review fine needle aspiration (FNA) results showing follicular from 2003 2012 was performed. Our practice is offer with FS patients; suspicious FS,...