A5087826096- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Inflammatory Bowel Disease
- IL-33, ST2, and ILC Pathways
- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Microscopic Colitis
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Surgical Treatments
- Gastrointestinal Tumor Research and Treatment
- Barrier Structure and Function Studies
- Cancer-related Molecular Pathways
- Colorectal and Anal Carcinomas
- Digestive system and related health
- Epigenetics and DNA Methylation
- Neuroendocrine Tumor Research Advances
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
Vanderbilt University Medical Center
2016-2025
Vanderbilt University
2015-2025
Vanderbilt-Ingram Cancer Center
2006-2025
Washington University in St. Louis
2014-2025
Bipar
2015-2023
Nashville Oncology Associates
2023
American College of Surgeons
2023
Duke University
1994-2020
Translational Genomics Research Institute
2017
College of American Pathologists
2013-2017
Stromal cells can have a significant impact on the carcinogenic process in adjacent epithelia. The role of transforming growth factor-beta (TGF-beta) signaling such epithelial-mesenchymal interactions was determined by conditional inactivation TGF-beta type II receptor gene mouse fibroblasts (Tgfbr2fspKO). loss responsiveness resulted intraepithelial neoplasia prostate and invasive squamous cell carcinoma forestomach, both associated with an increased abundance stromal cells. Activation...
Tenofovir disoproxil fumarate (DF) is a nucleotide analogue and potent inhibitor of human immunodeficiency virus type 1 reverse transcriptase hepatitis B (HBV) polymerase.
Gastric cancer is the fifth most frequently diagnosed and third leading cause of death from in world. Several advances have been made staging procedures, imaging techniques, treatment approaches. The NCCN Clinical Practice Guidelines Oncology (NCCN Guidelines) for Cancer provide an evidence- consensus-based approach management patients with gastric cancer. This manuscript discusses recommendations outlined staging, assessment HER2 overexpression, systemic therapy locally advanced or...
Chronic use of nonsteroidal anti-inflammatory drugs results in a significant reduction risk and mortality from colorectal cancer humans. All the mechanism(s) by which exert their protective effects are not completely understood, but they known to inhibit cyclooxygenase activity. The enzymes catalyze key reaction conversion arachidonic acid prostaglandins, such as prostaglandin E2 (PGE2). Here we demonstrate that PGE2 treatment LS-174 human carcinoma cells leads increased motility changes...
The NCCN Clinical Practice Guidelines in Oncology for Gastric Cancer provide evidence- and consensus-based recommendations a multidisciplinary approach the management of patients with gastric cancer. For resectable locoregional cancer, guidelines recommend gastrectomy D1+ or modified D2 lymph node dissection (performed by experienced surgeons high-volume centers). Postoperative chemoradiation is preferred option after complete resection T3-T4 tumors node-positive T1-T2 tumors. chemotherapy...
The College of American Pathologists offers these protocols to assist pathologists in providing clinically useful and relevant information when reporting results surgical specimen examinations. regards the elements "Surgical Pathology Cancer Case Summary (Checklist)" portion as essential pathology report. However, manner which are reported is at discretion each specific pathologist, taking into account clinician preferences, institutional policies, individual practice.The developed an...
Cancer-associated fibroblasts (CAFs) are major components of the carcinoma microenvironment that promote tumor progression. However, mechanisms by which CAFs regulate cancer cell migration poorly understood. In this study, we show fibronectin (Fn) assembled mediates CAF–cancer association and directional migration. Compared with normal fibroblasts, produce an Fn-rich extracellular matrix anisotropic fiber orientation, guides cells to migrate directionally. align Fn increasing nonmuscle...
Persistent gastritis induced by Helicobacter pylori is the strongest known risk factor for adenocarcinoma of distal stomach, yet only a fraction colonized persons ever develop gastric cancer. The H. cytotoxin-associated gene ( cag ) pathogenicity island encodes type IV secretion system that delivers bacterial effector CagA into host cells after attachment, and + strains augment cancer risk. A aberrantly activated in precursor lesions β-catenin, activation β-catenin leads to targeted...
Esophageal cancer is the sixth most common cause of deaths worldwide. Adenocarcinoma more in North America and Western European countries, originating mostly lower third esophagus, which often involves esophagogastric junction (EGJ). Recent randomized trials have shown that addition preoperative chemoradiation or perioperative chemotherapy to surgery significantly improves survival patients with resectable cancer. Targeted therapies trastuzumab ramucirumab produced encouraging results...
Epithelial neuroendocrine tumors (NETs) have been the subject of much debate regarding their optimal classification. Although multiple systems nomenclature, grading, and staging proposed, none has achieved universal acceptance. To help define underlying common features these classification to identify minimal pathology data that should be reported ensure consistent clinical management reproducibility from therapeutic trials, a multidisciplinary team physicians interested in NETs was...
Probiotic bacteria can potentially have beneficial effects on the clinical course of several intestinal disorders, but our understanding probiotic action is limited. We identified a bacteria-derived soluble protein, p40, from Lactobacillus rhamnosus GG (LGG), which prevents cytokine-induced apoptosis in epithelial cells. In current study, we analyzed mechanisms by p40 regulates cellular responses cells and p40's experimental colitis using mouse models. show that recombinant protein activated...
Context ERBB2 (erb-b2 receptor tyrosine kinase 2 or HER2) is currently the only biomarker established for selection of a specific therapy patients with advanced gastroesophageal adenocarcinoma (GEA). However, there are no comprehensive guidelines assessment HER2 in GEA. Objectives To establish an evidence-based guideline testing GEA, formalize algorithms methods to improve accuracy while addressing which and tumor specimens appropriate, provide guidance on clinical decision making. Design...
The spectrum of nonalcoholic fatty liver disease (NAFLD) includes steatosis, steatohepatitis (NASH), and cirrhosis. Recognition timely diagnosis these different stages, particularly NASH, is important for both potential reversibility limitation complications. Liver biopsy remains the clinical standard definitive diagnosis. Diagnostic tools minimizing need invasive procedures or that add information to histologic data are in novel management strategies growing epidemic NAFLD. We describe an...
Overview Upper gastrointestinal tract cancers originating in the esophagus, esophagogastric junction (EGJ), and stomach constitute a major health problem around world. An estimated 37,640 new cases of 25,070 deaths from upper occurred United States 2010.1 A dramatic shift location tumors has States.2,3 Changes hisNCCN
Abstract Extracellular vesicles and exomere nanoparticles are under intense investigation as sources of clinically relevant cargo. Here we report the discovery a distinct extracellular nanoparticle, termed supermere. Supermeres morphologically from exomeres display markedly greater uptake in vivo compared with small exomeres. The protein RNA composition supermeres differs highly enriched cargo involved multiple cancers (glycolytic enzymes, TGFBI, miR-1246, MET, GPC1 AGO2), Alzheimer’s...