A5036231550- Helicobacter pylori-related gastroenterology studies
- Polyamine Metabolism and Applications
- Galectins and Cancer Biology
- Gastric Cancer Management and Outcomes
- Eosinophilic Esophagitis
- Inflammatory Bowel Disease
- IL-33, ST2, and ILC Pathways
- Cancer Research and Treatments
- Immune Cell Function and Interaction
- Gut microbiota and health
- Amino Acid Enzymes and Metabolism
- Inflammatory mediators and NSAID effects
- Cancer-related gene regulation
- Veterinary medicine and infectious diseases
- Microscopic Colitis
- Gastrointestinal disorders and treatments
- Epigenetics and DNA Methylation
- AI in cancer detection
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Gastroesophageal reflux and treatments
- Immune cells in cancer
- Selenium in Biological Systems
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cytokine Signaling Pathways and Interactions
Vanderbilt University Medical Center
2016-2025
VA Tennessee Valley Healthcare System
2016-2025
Vanderbilt University
2015-2024
Powerscreen (United Kingdom)
2024
Nashville Oncology Associates
2012-2023
Bipar
2012-2022
Lemuel Shattuck Hospital
2022
Vanderbilt-Ingram Cancer Center
2011-2021
Tennessee Oncology
2021
Breast Cancer Research Foundation
2020
Probiotic bacteria can potentially have beneficial effects on the clinical course of several intestinal disorders, but our understanding probiotic action is limited. We identified a bacteria-derived soluble protein, p40, from Lactobacillus rhamnosus GG (LGG), which prevents cytokine-induced apoptosis in epithelial cells. In current study, we analyzed mechanisms by p40 regulates cellular responses cells and p40's experimental colitis using mouse models. show that recombinant protein activated...
Significance Theory predicts that chronic pathogens with vertical or familial transmission should become less virulent over time because of coevolution. Although transmitted in this way, Helicobacter pylori is the major causative agent gastric cancer. In two distinct Colombian populations similar levels H. infection but different incidences cancer, we examined human and pathogen ancestry matched samples to assess whether their genomic variation affects severity premalignant lesions....
Nonalcoholic fatty liver disease occurs frequently in the setting of metabolic syndrome, but factors leading to nonalcoholic steatohepatitis (NASH) are not fully understood. This study investigated Toll-like receptor 4 (TLR4) signaling human with goal delineating whether activation this pathway segregates those from NASH. Experiments were performed using biopsy tissue obtained class III obese subjects undergoing bariatric surgery, and extended an immortalized hepatocyte HepaRG cell line...
Significance The pathogenesis of many bacteria is enhanced by the ability to establish persistent infection. Macrophages, particularly classically activated M1 macrophages, provide essential functions in initiation antibacterial immune responses. regulation macrophage activation still poorly understood. Here, we demonstrate that ornithine decarboxylase (ODC), rate-limiting enzyme polyamine synthesis, regulates during Helicobacter pylori and Citrobacter rodentium Deletion Odc macrophages...
Countries endemic for parasitic infestations have a lower incidence of Crohn's disease (CD) than nonendemic countries, and there been anecdotal reports the beneficial effects helminths in CD patients. Tuft cells small intestine sense direct immune response against eukaryotic parasites. We investigated activities tuft patients with mouse models intestinal inflammation.
The segment anything model (SAM) was released as a foundation for image segmentation. promptable segmentation trained by over 1 billion masks on 11M licensed and privacy-respecting images. supports zero-shot with various prompts (e.g., points, boxes, masks). It makes the SAM attractive medical analysis, especially digital pathology where training data are rare. In this study, we evaluate performance of representative tasks whole slide imaging (WSI), including (1) tumor segmentation, (2)...
Analyzing high resolution whole slide images (WSIs) with regard to information across multiple scales poses a significant challenge in digital pathology. Multi-instance learning (MIL) is common solution for working by classifying bags of objects (i.e. sets smaller image patches). However, such processing typically performed at single scale (e.g., 20× magnification) WSIs, disregarding the vital inter-scale that key diagnoses human pathologists. In this study, we propose novel cross-scale MIL...
The antimicrobial effect of nitric oxide (NO) is an essential part innate immunity. vigorous host response to the human gastric pathogen Helicobacter pylori fails eradicate organism, despite up-regulation inducible NO synthase (iNOS) in mucosa. Here we report that wild-type strains H. inhibit production by activated macrophages at physiologic concentrations l -arginine, common substrate for iNOS and arginase. Inactivation gene rocF , encoding constitutively expressed arginase restored...
Gastric adenocarcinoma is strongly associated with Helicobacter pylori infection; however, most infected persons never develop this malignancy. H. strains harboring the cag pathogenicity island (cag+), which encodes CagA and a type IV secretion system (T4SS), induce more severe disease outcomes. infection also iron deficiency, similarly augments gastric cancer risk. To define influence of deficiency on microbial virulence in carcinogenesis, Mongolian gerbils were maintained iron-depleted...
Abstract The glutathione peroxidases, a family of selenocysteine-containing redox enzymes, play pivotal roles in balancing the signaling, immunomodulatory, and deleterious effects reactive oxygen species (ROS). peroxidase GPX3 is only extracellular member this family, suggesting it may defend cells against ROS environment. Notably, hypermethylation underexpression occur commonly prostate, gastric, cervical, thyroid, colon cancers. We took reverse genetics approach to investigate whether...