A5015321964- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Neuroendocrine Tumor Research Advances
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Pancreatitis Pathology and Treatment
- Clinical practice guidelines implementation
- Neuroblastoma Research and Treatments
- Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Esophageal Cancer Research and Treatment
- Viral-associated cancers and disorders
- Multiple and Secondary Primary Cancers
- Global Healthcare and Medical Tourism
- Helicobacter pylori-related gastroenterology studies
- Nutrition and Health in Aging
- Intraperitoneal and Appendiceal Malignancies
- Esophageal and GI Pathology
- Historical, Religious, and Philosophical Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Management of metastatic bone disease
West Virginia University
2018-2025
Northwestern University
2016-2024
University of Southern California
2016-2023
West Virginia State University
2023
The Ohio State University
2012-2022
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2012-2022
King County Medical Examiner's Office
2022
The Ohio State University Wexner Medical Center
2011-2021
University Hospital Ulm
2021
Providence Portland Medical Center
2021
The NCCN Guidelines for Hepatobiliary Cancers provide treatment recommendations cancers of the liver, gallbladder, and bile ducts. Panel meets at least annually to review comments from reviewers within their institutions, examine relevant new data publications abstracts, reevaluate update recommendations. These Insights summarize panel's discussion most recent regarding locoregional therapy patients with hepatocellular carcinoma.
Pain, depression, and fatigue function as a symptom cluster thus may share common risk factors. Interpersonal relationships clearly influence health, suggesting that loneliness promote the development of pain, cluster. We hypothesized would be related to concurrent levels increases in over time.We utilized two observational studies with distinct longitudinal samples. Study 1 was sample cancer survivors benign controls (N = 115) assessed annually for 2 years. older adults caring spouse...
In Brief Objective: This study hypothesized that tumor size, number of tumors, surgical approach, and histology significantly affected microwave ablation (MWA) success recurrence-free survival. Background: Although many hepatobiliary centers have adopted MWA, the factors influence local control are not well described. Methods: Consecutive patients with hepatic malignancy treated by MWA were included from 4 high-volume institutions (2003–2011) grouped histology: hepatocellular carcinoma...
To investigate the influence of type surgery (transplant vs resection) on overall survival (OS) in patients with hilar cholangiocarcinoma (H-CCA).Outcomes after resection for H-CCA are poor, yet transplantation is currently only reserved well-selected unresectable disease.All who underwent from 2000 to 2015 at 10 institutions were included. Three additionally had active transplant protocols similar selection criteria over time periods.Of 304 suspected H-CCA, 234 attempted and 70 enrolled a...
Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) is a long and complex procedure significant blood fluid loss during debulking important pathophysiological alterations the HIPEC phase. We performed retrospective analysis of 78 consecutive patients undergoing cytoreductive at university hospital. Our data demonstrate large intra-operative turnover, 51% requiring transfusion. During HIPEC, airway pressure central venous increased lower oxygenation ratio as result...
Objective: The objective of this study was to test the hypothesis that distal pancreatectomy (DP) without intraperitoneal drainage does not affect frequency grade 2 or higher complications. Background: use routine drains during DP is controversial. Prior study, no prospective trial focusing on has been reported. Methods: Patients undergoing for all causes at 14 high-volume pancreas centers were preoperatively randomized placement a drain drain. Complications and their severity tracked 60...
Macrophages are attracted to developing tumors and can participate in immune surveillance eliminate neoplastic cells. In response, cells utilize NF-κB suppress this killing activity, but the mechanisms underlying their self-protection remain unclear. Here, we report that dynamic interaction between tumor macrophages is integrally linked by a soluble factor identified as growth differentiation 15 (GDF-15). vitro, tumor-derived GDF-15 signals proapoptotic activity inhibiting TNF nitric oxide...
Objective: The aim of this study was to identify the optimal fistula mitigation strategy following pancreaticoduodenectomy. Background: utility technical strategies prevent clinically relevant postoperative pancreatic (CR-POPF) pancreatoduodenectomy (PD) may vary by circumstances anastomosis. Fistula Risk Score (FRS) identifies a distinct high-risk cohort (FRS 7 10) that demonstrates substantially worse clinical outcomes. value various in these particular high-stakes cases has not been...
Lipocalin-2 (LCN2) promotes malignant development in many cancer types. LCN2 is upregulated patients with pancreatic ductal adenocarcinoma (PDAC) and obese individuals, but whether it contributes to PDAC unclear. In this study, we investigated the effects of Lcn2 depletion on diet-induced obesity, inflammation, development. Mice acinar cell-specific expression KrasG12D were crossed Lcn2-depleted animals fed isocaloric diets varying amounts fat content. Pancreas collected analyzed for...
Highlights•Development of a mouse model pancreatic adenocarcinoma (PDA)-induced cachexia•Model develops progressive wasting associated with advancing pancreas pathology•Induction cachexia in adult KPP mice models tissue loss PDA cancer patients•Gene ontology cachectic muscles from resembles that patientsSummaryCachexia is syndrome characterized by pronounced skeletal muscle loss. In cancer, increased morbidity and mortality decreased treatment tolerance. Although advances have been made...
Background The objective of this study was to assess the prognostic performance American Joint Committee on Cancer (AJCC) 8th edition in patients with intrahepatic cholangiocarcinoma (ICC) using a cancer registry. Methods Surveillance, Epidemiology, and End Results (SEER) registry queried identify 1008 who underwent surgical resection ICC during 1998‐2013. Kaplan‐Meier method Cox proportional hazards regression models were used analyze long‐term survival. relative discriminative abilities...
To compare the prognostic performance of American Joint Committee on Cancer/International Union Against Cancer seventh N stage relative to lymph node ratio (LNR), log odds metastatic nodes (LODDS), and score in gastric adenocarcinoma.Metastatic disease regional LN basin is a strong predictor worse long-term outcome following curative intent resection adenocarcinoma.A total 804 patients who underwent surgical adenocarcinoma were identified from multi-institutional database. The discriminative...
<h3>Importance</h3> The current recommendation is to perform re-resection for select patients with incidentally discovered gallbladder cancer. optimal time interval both patient selection and long-term survival not known. <h3>Objective</h3> To assess the association of from initial cholecystectomy reoperation overall survival. <h3>Design, Setting, Participants</h3> This cohort study was conducted January 1, 2000, December 31, 2014 at 10 US academic institutions. A total 207 cancer who...
Cancer-associated wasting, termed cancer cachexia, has a profound effect on the morbidity and mortality of patients but remains difficult to recognize diagnose. While increases in circulating levels number inflammatory cytokines have been associated with these associations were generally made advanced disease thus may be progression rather than directly cachexia syndrome. Thus, we sought assess potential biomarkers cancer-induced earlier stages disease.A custom multiplex array was used...
E2F-mediated transcriptional repression of cell cycle–dependent gene expression is critical for the control cellular proliferation, survival, and development. E2F signaling also interacts with programs that are downstream genetic predictors cancer development, including hepatocellular carcinoma (HCC). Here, we evaluated function atypical repressor genes E2f7 E2f8 in adult liver physiology. Using several loss-of-function alleles mice, determined combined deletion hepatocytes leads to HCC....