A5067249314- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Cells and Metastasis
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- PI3K/AKT/mTOR signaling in cancer
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Gene expression and cancer classification
- Multiple Myeloma Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Chromatin Remodeling and Cancer
- CAR-T cell therapy research
- Cancer, Stress, Anesthesia, and Immune Response
- Bladder and Urothelial Cancer Treatments
- Immunotherapy and Immune Responses
- Protein Tyrosine Phosphatases
- Lymphoma Diagnosis and Treatment
- Cancer-related gene regulation
Moffitt Cancer Center
2019-2025
First Affiliated Hospital of GuangXi Medical University
2025
Guangxi Medical University
2023-2025
Ningbo University
2024
University of South Florida
2021-2023
Baylor College of Medicine
2012-2021
Dan L Duncan Comprehensive Cancer Center
2013-2021
Children's Cancer Center
2015-2020
Baylor University
2019
The University of Texas MD Anderson Cancer Center
2013-2018
ARID1A, SWI/SNF chromatin remodeling complex subunit, is a recently identified tumor suppressor that mutated in broad spectrum of human cancers. Thus, it fundamental clinical importance to understand its molecular functions and determine whether ARID1A deficiency can be exploited therapeutically. In this article, we report key function regulating the DNA damage checkpoint. recruited double-strand breaks (DSB) via interaction with upstream checkpoint kinase ATR. At level, facilitates...
Large-scale integrated cancer genome characterization efforts including the atlas and cell line encyclopedia have created unprecedented opportunities to study biology in context of knowing entire catalog genetic alterations. A clinically important challenge is discover subtypes their molecular drivers a comprehensive context. Curtis et al. [Nature (2012) 486(7403):346-352] has recently shown that integrative clustering copy number gene expression 2,000 breast tumors reveals novel subgroups...
To test by randomized prospective multicenter trial the hypothesis that pancreaticoduodenectomy (PD) without use of intraperitoneal drainage does not increase frequency or severity complications.Some surgeons have abandoned drains placed during pancreas resection.We 137 patients to PD with (n = 68, drain group) and 69, no-drain compared safety this approach spectrum complications between 2 groups.There were no differences cohorts in demographics, comorbidities, pathology, pancreatic duct...
Approximately 20% of patients with
Human-induced pluripotent stem cells (hiPSCs) are generated from somatic by ectopic expression of the 4 reprogramming factors (RFs) Oct-4, Sox2, Klf4, and c-Myc. To better define stoichiometric requirements dynamic patterns required for successful hiPSC induction, we bicistronic lentiviral vectors encoding RFs co-expressed with discernable fluorescent proteins. Using this system, optimal stoichiometry RF to be highly sensitive Oct4 dosage, demonstrate impact that variations in relative...
Breast cancer methylomes contribute to metastatic potential, modulate the metastasis transcriptome, and predict disease outcome.
Large-scale cancer genome projects, such as the Cancer Genome Atlas (TCGA) project, are comprehensive molecular characterization efforts to accelerate our understanding of biology and discovery new therapeutic targets. The accumulating wealth multidimensional data provides a paradigm for important research problems including subtype discovery. current standard approach relies on separate clustering analyses followed by manual integration. Results can be highly type dependent, restricting...
Identification of clinically relevant tumor subtypes and omics signatures is an important task in cancer translational research for precision medicine. Large-scale genomic profiling studies such as The Cancer Genome Atlas (TCGA) Research Network have generated vast amounts genomic, transcriptomic, epigenomic, proteomic data. While these provided great resources researchers to discover driver molecular alterations, there are few computationally efficient methods tools integrative clustering...
Context: Hurthle cell cancer (HCC) is an understudied with poor prognosis. Objective: Our objective was to elucidate the genomic foundations of HCC. Design and Setting: We conducted a large-scale integrated analysis mutations, gene expression profiles, copy number alterations in HCC at single tertiary-care institution. Methods: Mass spectrometry-based genotyping used interrogate hot spot point mutations most common thyroid oncogenes: BRAF, RET, NRAS, HRAS, KRAS, PIK3CA, MAP2K1, AKT1. In...
Vα24-invariant natural killer T cells (NKTs) localize to tumors and have inherent antitumor properties, making them attractive chimeric antigen receptor (CAR) carriers for redirected cancer immunotherapy. However, clinical application of CAR-NKTs has been impeded, as mechanisms responsible NKT expansion the in vivo persistence these are unknown. Here, we demonstrated that antigen-induced primary NKTs vitro associates with accumulation a CD62L+ subset exhaustion CD62L– cells. Only survived...
Objective: The objective of this study was to test the hypothesis that distal pancreatectomy (DP) without intraperitoneal drainage does not affect frequency grade 2 or higher complications. Background: use routine drains during DP is controversial. Prior study, no prospective trial focusing on has been reported. Methods: Patients undergoing for all causes at 14 high-volume pancreas centers were preoperatively randomized placement a drain drain. Complications and their severity tracked 60...
Successful embryo implantation requires a receptive endometrium. Poor uterine receptivity can account for failure in women who experience recurrent pregnancy loss or multiple rounds of unsuccessful vitro fertilization cycles. Here, we demonstrate that the transcription factor Forkhead Box O1 (FOXO1) is critical regulator endometrial vivo. Uterine ablation Foxo1 using progesterone receptor Cre (PgrCre) mouse model resulted infertility due to altered epithelial cell polarity and apoptosis,...
High resolution microarrays and second-generation sequencing platforms are powerful tools to investigate genome-wide alterations in DNA copy number, methylation gene expression associated with a disease. An integrated genomic profiling approach measures multiple omics data types simultaneously the same set of biological samples. Such renders an that would not be available any single type. In this study, we use penalized latent variable regression methods for joint modeling identify common...