A5100450732- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- T-cell and Retrovirus Studies
- Chronic Lymphocytic Leukemia Research
- Polyamine Metabolism and Applications
- Multiple Myeloma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Eosinophilic Disorders and Syndromes
- Hematological disorders and diagnostics
- Cutaneous lymphoproliferative disorders research
- Immune Cell Function and Interaction
- Histone Deacetylase Inhibitors Research
- Mast cells and histamine
- Viral-associated cancers and disorders
- Amino Acid Enzymes and Metabolism
- Biochemical and Molecular Research
- Hematopoietic Stem Cell Transplantation
- Diabetes and associated disorders
- Cancer-related gene regulation
- Immunodeficiency and Autoimmune Disorders
- Cancer Immunotherapy and Biomarkers
- CNS Lymphoma Diagnosis and Treatment
Moffitt Cancer Center
2016-2025
Beijing University of Chinese Medicine
2016-2025
Second Affiliated Hospital of Nanchang University
2025
Nanchang University
2024-2025
Sichuan University
2024-2025
First Affiliated Hospital of Nanchang University
2024
China National Pharmaceutical Group Corporation (China)
2023-2024
West China Hospital of Sichuan University
2024
Sun Yat-sen University
2011-2023
Children's Hospital of Chongqing Medical University
2021-2023
Approximately 20% of patients with
Immunotherapy is a revolutionized therapeutic strategy for tumor treatment attributing to the rapid development of genomics and immunology, immune checkpoint inhibitors have successfully achieved responses in numbers types, including hematopoietic malignancy. However, acute myeloid leukemia (AML) heterogeneous disease there still lack systematic demonstration apply immunotherapy AML based on PD-1/PD-L1 blockage. Thus, identification molecules that drive immunosuppression stratify patients...
Abstract Acute myeloid leukemia (AML) is a heterogeneous malignancy with outcomes largely predicted by genetic abnormalities. Mutations of NPM1 are common in AML, occurring ∼30% cases, and generally considered favorable risk factor. highly specific for secondary AML (sMut) have been shown to confer poor prognosis, but the overall impact these mutations setting favorable-risk defined mutant remains unclear. In this multicenter study patients (n = 233) mutation at diagnosis, we observed that...
Abstract Purpose: Proliferation of T-follicular helper (TFH) CD4+ T cells is a postulated pathogenic mechanism for T-cell non-Hodgkin lymphomas (T-NHL). The inducible costimulator (ICOS) highly expressed by TFH, representing potential target. MEDI-570 monoclonal antibody against ICOS, which eliminates ICOS+ in preclinical models. Patients and Methods: We report the safety, pharmacokinetics (PK), pharmacodynamics (PD), clinical activity T-NHL. NCI-9930 phase I, first-in-human study...
Bilirubin has anti-inflammatory, antioxidant, and anti-cancer properties, with an inverse relationship between its levels cancer risk prognosis. However, the prognostic value of serum bilirubin in acute myeloid leukemia (AML) remains uncertain. This retrospective study analyzed pretreatment total (TBIL), direct (DBIL), indirect (IBIL) 284 AML patients 316 healthy controls. The significance was determined using Kaplan-Meier method Cox proportional hazards model. Pretreatment TBIL IBIL were...
Perinatal nicotine exposure (PNE) induces pulmonary dysplasia in offspring and it increases the risk of respiratory diseases both across generations. The maternal gut microbiota its metabolites, such as short-chain fatty acids (SCFAs), can regulate fetal lung development are susceptible to exposure. Therefore, modulation PNE-induced changes SCFAs may prevent occurrence offspring. Our previous studies demonstrated that electroacupuncture (EA) ameliorated impairment development. To further our...
Context.— The co-occurrence of plasma cell neoplasm (PCN) and lymphoplasmacytic lymphoma (LPL) is rare, their clonal relationship remains unclear. Objective.— To evaluate the clinicopathologic characteristics concomitant LPL/PCN. Design.— Retrospectively analyzed clinical laboratory data 14 cases. Results.— Three patients initially presented with immunoglobulin (Ig) M paraprotein, 1 IgG 10 had simultaneous diagnoses PCN LPL. In 13 cases, flow cytometry detected both LPL in marrow biopsies....
Background and objectivesCastleman disease (CD) is a lymphoproliferative condition with broad range of morphological clinical presentations. It categorized into distinct pathological subtypes, including localized unicentric CD, idiopathic multicentric human herpesvirus 8-associated or 8-negative variants. Diagnosing CD requires adherence to internationally recognized guidelines that integrate clinical, laboratory, histological findings. However, distinguishing from other diseases can be...
Abstract Context.—The clinical association between loss of the Y chromosome and acute myelogenous leukemia myelodysplastic syndrome (AML/MDS) has been debated because both phenomena are related to aging. A prior publication suggests that in more than 75% cells may indicate a clonal phenomenon could be marker for hematologic disease. Objective.—To evaluate relationship AML/MDS. Design.—A retrospective review cytogenetic reports 2896 male patients ascertained from 1996 2007 was performed....
With the help of proteomics technology, human plasma and urine proteomes, which closely represent protein compositions input output kidney, respectively, have been profiled in much greater detail by different research teams. Many datasets accumulated to form "reference profiles" proteomes. Comparing these two proteomes may us understand handling aspect kidney function a way, however, has unavailable until recent advances technology.After removing secreted proteins downstream 2611 1522 were...
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy with dismal clinical outcomes. Conventional chemotherapies such cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) hyperfractionated dexamethasone alternating high-dose cytarabine methotrexate (CVAD) have been commonly used for the BPDCN treatment until recent study showed promising outcomes in patients treated SL-401 (Tagraxofusp). In this single-institution retrospective study, we...
Abstract MYC oncoproteins regulate transcription of genes directing cell proliferation, metabolism, and tumorigenesis. A variety alterations drive expression in acute myeloid leukemia (AML), enforced hematopoietic progenitors is sufficient to induce AML. Here we report that AML progenitor growth survival rely on MYC-directed suppression Transcription Factor EB (TFEB), a master regulator the autophagy–lysosome pathway. Notably, although originally identified as an oncogene, TFEB functions...
Malignant bone lymphoma can be classified as primary (PBL) or secondary (SBL) lymphoma. However, the clinico-pathological characteristics and prognostic factors of PBL versus SBL have not yet been well defined. Whether with multifocal involvement should considered stage IV still remain controversial throughout literature.In this study, we retrospectively reviewed 127 patients diagnosed from 1998 to 2013 at Moffitt Cancer Center. Patients were (81 cases) (46 using WHO Classification Bone/Soft...