A5083930709- Carbon and Quantum Dots Applications
- MRI in cancer diagnosis
- Nanocluster Synthesis and Applications
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Conducting polymers and applications
- Multiple Myeloma Research and Treatments
- Polyoxometalates: Synthesis and Applications
- Radiomics and Machine Learning in Medical Imaging
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Electrochemical sensors and biosensors
- Gastric Cancer Management and Outcomes
- Metal-Organic Frameworks: Synthesis and Applications
- Luminescence and Fluorescent Materials
- Immune cells in cancer
- Acute Lymphoblastic Leukemia research
- Single-cell and spatial transcriptomics
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Lung Cancer Treatments and Mutations
- Chemical Synthesis and Reactions
- High-Velocity Impact and Material Behavior
- Water Treatment and Disinfection
- Retinal Diseases and Treatments
Hebei Provincial Center for Disease Control and Prevention
2025
Beijing University of Chinese Medicine
2025
Yangzhou University
2025
Huazhong University of Science and Technology
2010-2024
Wuhan Municipal Engineering Design & Research Institute
2024
Sichuan University
2018-2024
West China Hospital of Sichuan University
2018-2024
Hunan Provincial Maternal and Child Health Hospital
2024
He Eye Hospital
2023-2024
Northwest A&F University
2024
Abstract Lung adenocarcinomas (LUAD) arise from precancerous lesions such as atypical adenomatous hyperplasia, which progress into adenocarcinoma in situ and minimally invasive adenocarcinoma, then finally adenocarcinoma. The cellular heterogeneity molecular events underlying this stepwise progression remain unclear. In study, we perform single-cell RNA sequencing of 268,471 cells collected 25 patients four histologic stages LUAD compare them to normal cell types. We detect a group closely...
Abstract The therapeutic index for chemotherapeutic drugs is determined in part by systemic toxicity, so strategies dose intensification to improve efficacy must also address tolerability. In addressing this issue, we have investigated a novel combinatorial strategy of reconstructing drug molecule and using sequential drug-induced nanoassembly fabricate supramolecular nanomedicines (SNM). Using cabazitaxel as target agent, established that individual synthetic prodrugs tethered with...
Background Despite an increasing understanding of chronic obstructive pulmonary disease (COPD) pathogenesis, the mechanisms diverse cell populations in human lung remain unknown. Using single-cell RNA sequencing (scRNA-Seq), we can reveal changes within individual COPD that are important for pathogenesis and characteristics. Methods We performed scRNA-Seq on tissue obtained from donors with non-COPD mild-to-moderate to identify disease-related genes different types. testified findings using...
The design and synthesis of effective recyclable oxidative desulfurization catalysts is great importance in view environmental protection human health. Herein, a family polyoxomolybdate-based inorganic–organic hybrid materials, namely, [Mn(TMR4A)(H2O)4][Mo6O19]·0.5CH3CH2OH·H2O (1), [Ni(TMR4A)(H2O)4][Mo6O19]·0.5CH3CH2OH·H2O (2), [Zn(TMR4A)(H2O)4][Mo6O19]·0.5CH3CH2OH·H2O (3), [Co2(TMR4A)2(H2O)4(β-Mo8O26)]·CH3CN·12H2O (4), were assembled by the functionalized resorcin[4]arene ligand (TMR4A)...
Purpose To investigate the efficacy of histogram analysis entire tumor volume in apparent diffusion coefficient (ADC) maps for differentiating between histological grades gastric cancer. Materials and Methods Seventy-eight patients with cancer were enrolled a retrospective 3.0T magnetic resonance imaging (MRI) study. ADC obtained at two different b values (0 1000 sec/mm2) each patient. Tumors delineated on slice maps, was subsequently generated. A series parameters (eg, skew kurtosis)...
Two remarkable polyoxometalate-bridged Cu(I)- and Ag(I)-thiacalix[4]arene dimers, namely, [Cu4(SiW12O40)(L)2(DMF)2]·2EtOH·DMF (1-Cu) [Ag4(PMo12O40)(L)2]·OH (1-Ag), were prepared by using a new thiacalix[4]arene, metal cation polyoxometalate (L = tetra[2-(ethylthio)-1-methyl-1H-imidazole]-thiacalix[4]arene). In 1-Cu 1-Ag, two thiacalix[4]arenes linked together one [SiW12O40]4- or [PMo12O40]3- anion via cations to give molecular dimer. Further, adjacent dimers extended into high-dimensional...
Two new inorganic–organic hybrid complexes, namely, {[Co4(L)2(HCOO)2(OH)2][SiO4(W3O9)4]}·6DMF·5H2O (1) and {[Zn4(L)2(HCOO)2(OH)2][SiO4(W3O9)4]}·6DMF·5H2O (2), have been solvothermally prepared by using a methyl imidazole functionalized resorcin[4]arene (L), polyoxometalate (POM), metal cation. Isostructural 1 2 feature porous supramolecular architectures represent an unusual example of successful combination resorcin[4]arenes with polyoxometalates. Remarkably, selective adsorptions for...
Fluorescence imaging of cellular metals is widely reported. However, the quantification intracellular with fluorescence so far not feasible and highly challenging. In this work, a ratiometric probe two fluorescently labeled complementary DNA strains designed for zinc via imaging, based on resonance energy transfer (FRET) from carbon dots (CDs) to fluorescein (FAM). The donor CDs are modified Zn2+ aptamer, whereas receptor FAM conjugated sequence ensure selectivity. MCF-7 cells cultured...
Introduction: According to traditional Chinese veterinary medicine, endometritis is caused by a combination of Qi deficiency, blood stasis, and external evil invasion. Salvia miltiorrhiza medicine that counteracts stasis has additional demonstrated effects in boosting energy restraining inflammation. been employed many prescriptions have proven effective healing clinical dairy cow endometritis. Methods: the vivo effect treating was evaluated cows. In addition, bovine endometrial epithelium...
Perinatal nicotine exposure (PNE) induces pulmonary dysplasia in offspring and it increases the risk of respiratory diseases both across generations. The maternal gut microbiota its metabolites, such as short-chain fatty acids (SCFAs), can regulate fetal lung development are susceptible to exposure. Therefore, modulation PNE-induced changes SCFAs may prevent occurrence offspring. Our previous studies demonstrated that electroacupuncture (EA) ameliorated impairment development. To further our...
Objective: To analyze the prevalence of chronic kidney disease (CKD) and influencing factors adults in Hebei Province, provide scientific evidence for development comprehensive CKD prevention control strategies. Methods: In China Adult Chronic Disease Nutrition Surveillance 2018, a total 7 562 permanent residents aged ≥18 years were selected by multi-stage stratified cluster random sampling from 13 surveillance points questionnaire survey, medical examination laboratory test. Results: A 1...
Nipah virus (NiV) is a severe zoonotic pathogen that substantially threatens public health. Pigs are the natural hosts of NiV and can potentially transmit this disease to humans. Establishing rapid, sensitive, accurate point-of-care detection method critical in timely identification infected pig herds. In study, we developed an based on reverse transcription–recombinase polymerase amplification (RT-RAA) clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 13a...
The optical properties of organic materials are very sensitive to subtle structural modification, and a proper understanding the structure-property relationship is essential improve performance electronic devices. phase transitions η-CuPc α-CuPc, then β-CuPc were investigated using In situ X-ray diffraction differential scanning calorimetry (DSC). five stages in phase-transition process from low high-temperature observed, which consisted (1) η-CuPc; (2) mixture η- α-CuPc; (3) η-, α- β-CuPc;...