A5100679324- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Pediatric health and respiratory diseases
- Urinary Tract Infections Management
- Ferroptosis and cancer prognosis
- Bone health and osteoporosis research
- Birth, Development, and Health
- Plant Pathogens and Fungal Diseases
- Body Composition Measurement Techniques
- Reproductive System and Pregnancy
- Stress Responses and Cortisol
- Nutrition and Health in Aging
- Plant-Microbe Interactions and Immunity
- Acupuncture Treatment Research Studies
- Plant Reproductive Biology
- Anesthesia and Neurotoxicity Research
- Age of Information Optimization
- Reproductive Biology and Fertility
- Plant Molecular Biology Research
- Antibiotics Pharmacokinetics and Efficacy
- Cancer, Lipids, and Metabolism
- Plant Stress Responses and Tolerance
- Cell death mechanisms and regulation
- Reproductive Health and Contraception
- Neonatal and fetal brain pathology
Beijing University of Chinese Medicine
2016-2025
Harbin Medical University
2024
Central South University
2023-2024
First Affiliated Hospital of Harbin Medical University
2024
Xiangya Hospital Central South University
2023-2024
Yan'an University
2023
Yanan University Affiliated Hospital
2023
Beijing Hospital of Traditional Chinese Medicine
2005-2023
Huazhong Agricultural University
2023
Virginia Tech
2022
Background Angiogenesis, the process of forming new blood vessels from pre-existing ones, plays a crucial role in development and advancement cancer. Although blocking angiogenesis has shown success treating different types solid tumors, its relevance prostate adenocarcinoma (PRAD) not been thoroughly investigated. Method This study utilized WGCNA method to identify angiogenesis-related genes assessed their diagnostic prognostic value patients with PRAD through cluster analysis. A model was...
Abstract Background Prostate cancer (PCa) is the second leading cause of tumor-related mortality in men. Metastasis from advanced tumors primary death among patients. Identifying novel and effective biomarkers essential for understanding mechanisms metastasis PCa patients developing successful interventions. Methods Using GSE8511 GSE27616 data sets, 21 metastasis-related genes were identified through weighted gene co-expression network analysis (WGCNA) method. Subsequent functional these was...
Abstract YARS is responsible for catalysing the binding of tyrosine to its cognate tRNA and plays a crucial role in basic biosynthesis. However, biological functions bladder cancer remains be proven. We analysed variations YARS1 expression survival using multiple data sets, including TCGA‐BLCA, GSE13507 cancer‐specific tissue microarrays. Furthermore, we explored transcriptome data. Our findings revealed noteworthy correlation between immune infiltration cancer, as determined XCELL algorithm...
Although date palm is relatively salt-tolerant, little known about the underlying molecular mechanisms that contribute to its salt tolerance. Only recently, investigators have uncovered microRNA-mediated post-transcriptional gene regulation, which critical for typical plant development and adaptation stress conditions such as salinity. To identify conserved novel miRNAs in characterize could play a role tolerance, we generated sRNA libraries from leaves roots of NaCl-treated untreated...
Perinatal nicotine exposure (PNE) induces pulmonary dysplasia in offspring and it increases the risk of respiratory diseases both across generations. The maternal gut microbiota its metabolites, such as short-chain fatty acids (SCFAs), can regulate fetal lung development are susceptible to exposure. Therefore, modulation PNE-induced changes SCFAs may prevent occurrence offspring. Our previous studies demonstrated that electroacupuncture (EA) ameliorated impairment development. To further our...
Various types of mutation and editing (M/E) events in microRNAs (miRNAs) can change the stabilities pre-miRNAs and/or complementarities between miRNAs their targets. Small RNA (sRNA) high-throughput sequencing (HTS) profiles contain many mutated edited miRNAs. Systematic detection miRNA sites from huge volume sRNA HTS is computationally difficult, as high sensitivity low false positive rate (FPR) are both required. We propose a novel method (named MiRME) for an accurate fast M/E using...
Introduction Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae pose a huge threat to human health, especially in the context of complicated urinary tract infections (cUTIs). Carbapenems and piperacillin–tazobactam (PTZ) are two antimicrobial agents commonly used treat cUTIs. Methods A monocentric retrospective cohort study focused on treatment cUTIs adults was conducted from January 2019 November 2021. Patients with positive urine culture strain yielding ≥ 103 colony-forming...
In this paper, we consider a discrete-time information-update system, where service provider can proactively retrieve information from the source to update its data and users query at provider. One example is crowdsensing-based applications. order keep satisfied, application desires provide with fresh data, freshness measured by Age-of-Information (AoI). However, maintaining requires database frequently, which incurs an cost (e.g., incentive payment). Hence, there exists natural tradeoff...
Abstract Background We have updated the guideline for preventing and managing perioperative infection in China, given global issues with antimicrobial resistance need to optimize usage improve hospital control levels. Methods conducted a comprehensive evaluation of evidence prevention management infection, based on concepts Grading Recommendations Assessment, Development Evaluation (GRADE) system. The strength recommendations was graded voted using Delphi method nominal group technique....
Chai Hu (Radix Burpleuri), a major ingredient in many traditional Chinese medicine formulas, such as Xiao Yao Wan, is used the treatment of liver stagnation and spleen deficiency syndrome (LSSDS). The objectives this study were to examine effects Wan containing on changes plasma indices patients with LSSDS. Fifty-eight cases LSSDS randomly divided into two groups: 41 experimental group treated 17 control Zhi Bai Di Huang for one consecutive month single blind design. Before after treatment,...
Three new helvolic acid derivatives (named sarocladilactone A (1), B (2) and sarocladic (3a)), together with five known compounds (6,16-diacetoxy-25-hy- droxy-3,7-dioxy-29-nordammara-1,17(20)-dien-21-oic (3b), (4), helvolinic (5), 6-desacetoxy-helvolic (6) 1,2-dihydrohelvolic (7)), were isolated from the endophytic fungus DX-THL3, obtained leaf of Dongxiang wild rice (Oryza rufipogon Griff.). The structures elucidated via HR-MS, extensive 1D 2D NMR analysis comparison reported data....
Many factors during pregnancy can induce intrauterine growth restriction (IUGR), resulting in various adverse perinatal outcomes such as low birth weight and multiple organ disorders. Among these factors, prenatal smoke/nicotine exposure is a common cause of IUGR, often associated with altered fetal lung development. The classical Wnt signaling pathway plays vital role development, its alterations are commonly developmental pathologies. purpose this study was to determine whether...
Yifuning is a traditional Chinese medicine recipe that has been used for many years in China its effects on treating climacteric syndrome women. The present study aimed to demonstrate the and underlying molecular mechanism of ovaries aging rats. Selected rats were administered different doses (1.0 or 2.0 g/kg by lavage), after 6 weeks sacrificed. activit indicators oxidative stress serum measured. expression levels 8-oxo-2'-deoxyguanosine (8-OHDG) p53 examined using immunohistochemistry....
Perinatal nicotine exposure alters offspring lung structure and function; however, the underlying mechanisms remain incompletely understood. Whether epithelial-mesenchymal transition (EMT), a known contributor to pulmonary pathology, occurs following moderate perinatal is not known.Pregnant, pair-fed Sprague Dawley rat dams received either placebo (diluent) or [1 mg/kg, subcutaneously] once daily from embryonic day (e) 6 postnatal (PND) 21. Generation 1 (F1) 3 (F3) lungs were isolated at PND...
Introduction . Environmental exposure of the developing offspring to cigarette smoke or nicotine is an important predisposing factor for many chronic respiratory conditions, such as asthma, emphysema, pulmonary fibrosis, and so forth, in exposed offspring. Studies showed that electroacupuncture (EA) applied maternal “Zusanli” (ST36) acupoints during pregnancy lactation protects against perinatal exposure‐ (PNE‐) induced lung damage. However, most effective time period, is, prenatal vs....
Background . Maternal smoking and/or exposure to environmental tobacco smoke continue be significant factors in fetal and childhood morbidity are a serious public health issue worldwide. Nicotine passes through the placenta easily with minimal biotransformation, entering circulation, where it results many harmful effects on developing offspring, especially respiratory system. Objectives Recently, rat model, electroacupuncture (EA) at maternal acupoints ST 36 has been shown block perinatal...
Local acupuncture has been found to have a good analgesic effect in rats with cervical spondylosis radiculopathy (CSR), but it lacks regulatory on traditional Chinese medicine syndrome types of CSR. We proposed "Invigorating Qi and activating Blood" (IQAB) acupuncture, compared Fenbid, local electroacupuncture (LEA), observe whether advantages the protection CSR rat model elucidate its mechanism through MAPK (mitogen-activated protein kinase) signaling pathway.Male Sprague-Dawley were...