A5100769830- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune Cell Function and Interaction
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- Hepatitis B Virus Studies
- Asphalt Pavement Performance Evaluation
- CAR-T cell therapy research
- Gastric Cancer Management and Outcomes
- Circular RNAs in diseases
- Cancer Mechanisms and Therapy
- Liver Disease and Transplantation
- Immune cells in cancer
- Genomics and Phylogenetic Studies
- Infrastructure Maintenance and Monitoring
- MicroRNA in disease regulation
- Hepatitis C virus research
- RNA modifications and cancer
- Liver Diseases and Immunity
- Autophagy in Disease and Therapy
- Liver physiology and pathology
- Endoplasmic Reticulum Stress and Disease
Wuhan University of Science and Technology
2025
Hokkaido University
2022-2025
Zhejiang University
2020-2025
Jilin Medical University
2025
Beijing University of Technology
2023-2024
Guiyang College of Traditional Chinese Medicine
2023-2024
Guizhou University
2024
Second Affiliated Hospital of Jilin University
2024
First Affiliated Hospital of Anhui Medical University
2023-2024
Anhui Medical University
2023-2024
Abstract Increasing evidence shows that the anti-tumor functions of tumor-infiltrating T lymphocytes (TILs) were inhibited significantly, but underlying mechanisms remain not fully understood. In this study, we found 14-3-3ζ expression was up-regulated in hepatocellular carcinoma (HCC) cells and TILs. TILs with high-expression (14-3-3ζ high ) exhibited impaired activation (CD69), proliferation (Ki67) compared to low Flow cytometry assay showed CD8 + cells, ones higher frequency exhausted...
Considering the narrow window of surgery, early diagnosis liver cancer is still a fundamental issue to explore. Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICCA) are considered as two different types because their distinct pathogenesis, pathological features, prognosis, responses adjuvant therapies. Qualitative analysis image not enough make discrimination cancer, especially early-stage HCC or ICCA.This retrospective study developed radiomic-based model in training...
To establish and validate a radiomics-based model for staging liver fibrosis at contrast-enhanced CT images.This retrospective study developed two models (R-score: radiomics signature; R-fibrosis: integrate radiomic serum variables) in training cohort of 332 patients (median age, 59 years; interquartile range, 51-67 256 men) with biopsy-proven who underwent between January 2017 December 2020. Radiomic features were extracted from non-contrast, arterial portal phase images selected using the...
Children delivered by elective C-section are not exposed to the birth canal and show altered microbiota development. Impairing microbial colonization during early life alters metabolic immune programming is associated with an increased risk of diseases.
In this study, male F344 rats were orally exposed to aflatoxin B1 (AFB1) at 0, 5, 25, and 75 μg/kg for 4 weeks. Rat feces collected from 2 weeks following exposure assessed gut-microbiota-dependent metabolites. Gut-microbiota-related organic acids quantitated in the using 2-nitrophenylhydrazine derivatization coupled HPLC-profiling method which was validated showed good reliability, accuracy sensitivity. After 2-week exposure, AFB1 significantly reduced levels of fecal short-chain fatty...
To establish and validate a radiomics-based model for predicting liver cirrhosis in patients with hepatitis B virus (HBV) by using non-contrast computed tomography (CT).This retrospective study developed training cohort of 144 HBV-infected patients. Radiomic features were extracted from abdominal CT scans. Features selection was performed the least absolute shrinkage operator (LASSO) method based on highly reproducible features. Support vector machine (SVM) adopted to build radiomics...
We investigated the effects of bepridil on two components delayed rectifier K + current, i.e., rapidly activating (I Kr ) and slowly Ks currents using tight‐seal whole‐cell patch‐clamp techniques in guinea‐pig ventricular myocytes, under blockade L‐type Ca 2+ current with nitrendipine (5 μ M or D600 (1 ). Bepridil decreased I E4031 ), a concentration‐dependent manner. The inhibition by was fitted curve, assuming one‐to‐one interactions between channel drug molecule. concentration...
To explore the prognosis of tumor mutation burden (TMB) and underlying relationships with tumor-infiltrating immune cells in bladder cancer (BLCA). Transcriptome profiles somatic data from The Cancer Genome Atlas database by GDC tool. A total 437 samples were included, consisted 412 BLCA patients matched 25 normal samples. Specific information was summarized illustrated waterfall plot. Higher TMB levels revealed improved overall survival (OS) lower recurrence. We found 68 differentially...
Previous circular RNA (circRNA) microarray analyses have uncovered an abnormal expression of hsa_circ_0070963 in hepatic stellate cells (HSCs).However, the specific role liver fibrosis remains unknown.Here, we show that inhibits via regulation miR-223-3p and LEMD3.Moreover, demonstrated levels were reduced during while restoring abolished HSC activation, with a reduction α-SMA type I collagen both vitro vivo.Furthermore, overexpression suppressed cell proliferation cycle HSCs.MiR-223-3p was...
Gallbladder polyps (GBPs) are relatively common. Many studies have attempted to distinguish between benign and neoplastic GBPs identify early-stage gallbladder carcinoma. We established an accurate predictive model evaluated the effectiveness of radiomics in predicting malignancy patients with GBPs.A total 503 confirmed through postoperative pathology were included this retrospective study. Clinical information ultrasonographic findings retrospectively analyzed. The was constructed from...
Background: Robot-assisted laparoscopic cystectomy with intracorporeal urinary diversion (iRARC) is increasingly being used in recent years. Whether iRARC offers advantages over open radical (ORC) remains controversial. This study aimed to compare the difference of perioperative outcomes, oncological outcomes and complications between ORC. Methods: The PubMed, Embase, Cochrane Library, Web Science CNKI databases were searched July 2023 according PRISMA (Preferred Reporting Items for...
Abstract: BACKGROUND: The N2H3 model was evaluated for forecasting the 3-month outcomes patients experiencing acute ischemic stroke who received intravenous thrombolysis (IVT), in our previous study. present study aimed to validate predictive ability of and compare its accuracy THRIVE-c START models (both which are widely employed prognostic predictions following IVT). METHODS: Our prospectively enrolled consecutive IVT from 16 hospitals. Cases one hospital were included External Validation...
The management of chronic diabetic wounds is a complex challenge requiring local glycemic regulation, modulation inflammation levels, and prevention bacterial infections. Therefore, multifunctional wound dressing with antioxidant, glycocontrol, antibacterial properties developed to promote healing. This constructed by co-loading gold-cerium oxide (AuCeO2) dumbbells glucose oxidase (GOx) into reactive oxygen species (ROS)-sensitive hydrogel matrix (ACG gels). In this system, Au-CeO2...