A5100664945- Cancer-related molecular mechanisms research
- Colorectal Cancer Treatments and Studies
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Parasitic infections in humans and animals
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Surgical Treatments
- Medical Imaging and Analysis
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Pelvic and Acetabular Injuries
- Colorectal and Anal Carcinomas
- Urological Disorders and Treatments
- Parasites and Host Interactions
- Musculoskeletal pain and rehabilitation
- TGF-β signaling in diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
Zhejiang Provincial People's Hospital
2017-2025
Hangzhou Medical College
2017-2025
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2023-2025
Beijing Children’s Hospital
2025
Capital Medical University
2025
Peking University First Hospital
2025
Peking University
2025
First Affiliated Hospital of Bengbu Medical College
2025
Zhengzhou University
2025
Nanjing Medical University
2015-2024
Abstract Programmed cell death protein-1 (PD-1)-mediated immunosuppression has been proposed to contribute the limited clinical efficacy of chimeric antigen receptor T (CAR-T) cells in solid tumors. We generated PD-1 and (TCR) deficient mesothelin-specific CAR-T (MPTK-CAR-T) using CRISPR-Cas9 technology evaluated them a dose-escalation study. A total 15 patients received one or more infusions MPTK-CAR-T without prior lymphodepletion. No dose-limiting toxicity unexpected adverse events were...
Abstract Our previous study demonstrated a progressive glycolytic perturbation during the course of DMBA-induced hamster oral carcinogenesis, which was attenuated by salvianolic acid B (Sal-B) treatment along with decreased incidences squamous cell carcinoma (OSCC) formation. It proposed that metabolic modulation should be an additional mode action attributable to Sal-B’s anti-carcinogenic activity. However, molecular mechanisms underlying Sal-B-induced function remained elusive. In present...
Abstract Transplant rejection is the key problem in organ transplantation and, clinic, immunosuppressive agents such as tacrolimus are directly administered to recipients after surgery for T‐cell inhibition. However, direct administration of may bring severe side effects recipients. Herein, by rational design two hydrogelators NapPhePheGluTyrOH ( 1 ) and Nap d ‐Phe PheGluTyrOH 2 ), a facile method immune responsive release developed from their hydrogels overcome rejection. Upon...
Abstract Circular RNAs (circRNAs), non-coding generated by precursor mRNA back-splicing of exons, have been reported to fulfill multiple roles in cancer. However, the role quite a lot circRNAs colorectal cancer (CRC) remains mostly unknown. Herein, we explored expression profiles 5 paired samples CRC patients microarray and noted circRNA, hsa_circ_0005615 (circ5615), was significantly upregulated tissues. Circ5615 derived from exon 2 NFATC3 its upregulation tightly correlated with higher T...
Background: Protein arginine methyltransferase 5 (PRMT5) is a type II that symmetrically di-methylates residues on both histone and non-histone protein substrates. Accumulating evidence suggests PRMT5 exerts its oncogenic properties in wide spectrum of human malignancies. However, the underlying mechanisms by which contributes to progression colorectal cancer (CRC) remain be defined. Methods: Western blot real-time PCR were used analyze expression CDKN2B. Co-immunoprecipitation (Co-IP),...
Considering the narrow window of surgery, early diagnosis liver cancer is still a fundamental issue to explore. Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICCA) are considered as two different types because their distinct pathogenesis, pathological features, prognosis, responses adjuvant therapies. Qualitative analysis image not enough make discrimination cancer, especially early-stage HCC or ICCA.This retrospective study developed radiomic-based model in training...
ABSTRACT Objective Allocation of medical resource is essential to a strong public health system in response COVID-19. Analysis confirmed COVID-19 patients’ hospital length stay Sichuan can be informative decision-making other regions the world. Design A retrospective cross-sectional study. Data and Method from cases Province were obtained National Notifiable Diseases Reporting System (NNDRS) field survey. We collected information on demographic, epidemiological, clinical characteristics, for...
Throughout much of human history, the vast majority people lived in small communities. However, last few centuries, and particularly recent decades, there has been a dramatic shift. A massive migration moved populations from rural to urban areas. United Nations reports state that over 4.3 billion individuals now inhabit regions, which accounts for more than half (55% as 2017) global population. In most high-income nations, including Western Europe, Americas, Australia, Japan, Middle East,...
Purpose: Anastomotic leakage (AL) is associated with high morbidity and mortality, reoperation rates, increased hospital length of stay. Here we investigated the risk factors for AL after anterior resection rectal cancer a double stapling technique. Patients Methods: Data 460 patients who underwent primary technique carcinoma at single institution from 2003 to 2007 were prospectively collected. All experienced total mesorectal excision (TME) operation. Clinical was defined as presence signs...
Paclitaxel has been widely used in the treatment of breast cancer. However, development drug resistance often increases failure chemotherapy. Growing evidence reported significant role microRNAs (miRs) resistance. The present study identified that miR‑24 was significantly downregulated paclitaxel‑resistant (PR) cancer patients and MCF‑7/PR human carcinoma cells, overexpression could increase effect paclitaxel on drug‑resistant cells. Furthermore, directly bind to 3'‑untranslated region ATP...
170 Background: This is a randomized, double-blind, multicenter phase 2/3 study comparing the efficacy and safety of serplulimab (a novel anti-PD-1 antibody) plus bevacizumab XELOX chemotherapy vs. placebo as first-line treatment for metastatic colorectal cancer (mCRC). Our previous presentation at 2024 ASCO Meeting showed progression-free survival results. Here we present updated findings together with subgroup analysis results after median follow-up 31.0 months. Methods: A total 114...
The role of frailty in the associations fine particulate matter (PM2.5) with depression and anxiety was unknown. This study is a longitudinal population-based cohort study. A total 444,094 UK Biobank participants without or at baseline were included. PM2.5 concentrations phenotype measured baseline, while incident identified during median follow-up 7.8 years. multivariable cox regression model utilized to evaluate prospective relationships between PM2.5/frailty risk anxiety. Mediation...
Abstract Background: Developing personalized treatment plans in cancer care is a complex and time-intensive process. The multidisciplinary Molecular Tumor Board (MTB) approach offers promising solution for tailoring precision treatments but often limited by the manual analysis of vast molecular data, which laborious error-prone. To address these challenges, we developed SmartMTB, an artificial intelligence (AI)-based assistant, designed to support clinicians formulating cost-effective...
Purpose: To investigate the risk factors for anastomotic leakage (AL) after anterior resection rectal cancer with a double stapling technique. Patients and Methods: Between January 2004 December 2011, 753 consecutive patients in Jiangsu Cancer Hospital Research Institute diagnosed undergoing technique were recruited. All experienced total mesorectal excision (TME) operation. Additionally, decrease of postoperative tumor supplied group (TSGF), which have not been reported before, was proposed...
Esophageal squamous cell carcinoma (ESCC) is one of the major causes cancer death worldwide, especially in Eastern Asia. Due to poor prognosis, it necessary further dissect underlying mechanisms and explore therapeutic targets ESCC. Recently, studies show that long noncoding RNAs (lncRNAs) have critical roles diverse biological processes, including tumorigenesis. Increasing evidence indicates some lncRNAs are widely involved development progression ESCC, such as HOTAIR, SPRY4-IT1 POU3F3. An...