A5101425694- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Uterine Myomas and Treatments
- NF-κB Signaling Pathways
- Endometrial and Cervical Cancer Treatments
- Bioactive Natural Diterpenoids Research
- Endometriosis Research and Treatment
- Immunotoxicology and immune responses
- Tissue Engineering and Regenerative Medicine
- Cancer-related gene regulation
- Melanoma and MAPK Pathways
- Microbial Metabolism and Applications
- Protease and Inhibitor Mechanisms
- RNA Research and Splicing
- Chemokine receptors and signaling
- Nerve injury and regeneration
- Cancer Genomics and Diagnostics
- Nutrition, Genetics, and Disease
- Lipid metabolism and biosynthesis
- PI3K/AKT/mTOR signaling in cancer
- S100 Proteins and Annexins
- Extracellular vesicles in disease
- TGF-β signaling in diseases
Xuzhou Cancer Hospital
2023
Jiangsu University
2023
Nanjing Maternity and Child Health Care Hospital
2013-2022
Nanjing Medical University
2013-2022
Jiangsu Province Hospital
2022
Shihezi University
2014-2022
Henan University
2022
Second Hospital of Shanxi Medical University
2014-2019
Shanxi Medical University
2014-2019
CAO Group (United States)
2007
The composition and biological activity of donor cells is largely determined by the exosomes they secrete. In this study, we isolated from young (Young-Exo) aged (Age-Exo) mesenchymal stem (MSCs) compared their regeneration activity. Young Exo MSCs were more efficient than Aged-Exo at promoting formation endothelial tube, reducing fibrosis, inhibiting apoptosis cardiomyocytes in vitro; improving cardiac structure function vivo hearts rats following myocardial infarction (MI). MicroRNA...
Abstract Background Mesenchymal stromal cells (MSCs) activated with IFN-γ elicit stronger physical effects. Exosomes (Exos) secreted from MSCs show protective effects against myocardial injury. This study aimed to determine whether Exos derived IFN-γ-treated exhibit more potent cardioprotective function and the underlying mechanisms. Methods H9c2 or human umbilical vein endothelial (HUVECs) were treated isolated (Ctrl-Exo) IFN-γ-primed (IFN-γ-Exo) under oxygen glucose deprivation (OGD)...
Severe obesity (SevO) is a primary driver of cardiovascular diseases (CVD), cardiometabolic (CMD) and several cancers, with disproportionate impact on marginalized populations. SevO an understudied global health disease, limiting knowledge about its mechanisms impacts. In genome-wide association study (GWAS) meta-analyses the tail end BMI distribution (≥95th percentile BMI) two phenotypes [Obesity Class III ≥40 kg/m2 Obesity IV ≥50 kg/m2] in 159,359 individuals across eleven ancestrally...
Long non-coding RNA (lncRNA) HOTAIR acts importantly in liver cancer development, but its effect on radioresistance remains poorly understood. Here, our study probed into the possible impact of stem cells (LCSCs) and to elucidate molecular basis.Following sorting non-stem cells, LCSCs were identified subjected RNA-seq analysis for selecting differentially expressed genes. Expression was determined tissues CSCs. The stemness, proliferation, apoptosis then detected response altered expression...
Abstract Background Human papillomavirus type 16 (HPV 16) E2 protein is a multifunctional DNA-binding protein. HPV regulates many biological responses, including DNA replication, gene expression, and apoptosis. The purpose of this study was to investigate the relationship among receptor for globular heads human C1q (gC1qR) transfection apoptosis regulation in cervical squamous carcinoma cells (C33a SiHa). Methods gC1qR expression examined C33a SiHa using real-time PCR Western blot analysis....
Background/Aims: The purpose of this study was to investigate the relationships among exposure coplanar polychlorinated biphenyls (Co-PCBs), expression gC1qR and underlying intracellular apoptotic signaling pathways human extravillous cytotrophoblast (EVCT)-derived transformed cells (HTR-8/SVneo HPT-8). Methods: Apoptosis in HTR-8/SVneo HPT-8 assessed using flow cytometric analysis. gClqR examined real-time qPCR western blot analyses. phosphorylations p38 mitogen-activated protein kinase...
Stress-activated protein kinase (SAPK) interacting 1 (SIN1) is an essential TORC2 component and a key regulator of Akt pathway that plays important role in various pathological conditions including cancer. Whereas its functional breast cancer has not been well characterized. In the present study, SIN1 associated with progression survival patients, as human cell proliferation migration. mRNA level was significantly up-regulated samples compared their corresponding paracancerous histological...
Studies have demonstrated that miR-335-5p exhibits an essential role in the progress of multiple tumors, including thyroid cancer, pancreatic and non-small-cell lung cancer. However, possible expression, detailed role, underlying mechanisms uterine leiomyoma (UL) still remained unclear. Therefore, present study was designed to investigate mechanism function UL. In our study, microRNA-335-5p (miR-335-5p) is significantly downregulated UL tissues cell lines, especially HCC1688 SK-UT-1 cells....
Like dandelion, dandelion seed also have anti-inflammatory activity. Therefore, in this article, we intend to explore the anti-cancer availability of aqueous extract (DSE) esophageal squamous cell carcinoma (ESCC). Firstly, effects DSE on proliferation, apoptosis, migration, invasion and angiogenesis were investigated. Then mechanism against ESCC, levels proliferation-associated proteins (PI3K, Akt pAkt), apoptosis-associated (survivin, Bcl-2, Bax, caspase3 caspase9), metastasis-associated...
The incidence of melanoma has been increasing over the last 30 years. most common treatments, such as surgery, chemotherapy, and radiotherapy, frequently cause serious damage to body. It is therefore critical develop a new therapeutic strategy for treatment melanoma.This research aims evaluate anti-tumor effect Neochamaejasmine A (NCA) on B16F10 cells underlying molecular mechanisms.The CCK-8 kit was utilized assay influence NCA vitality cells. Modifications in morphology were observed using...
Uterine leiomyoma (ULM) is a kind of gene-involved benign tumor, which located in the front female reproductive tract. It one most common tract tumors women, leads to abnormal menstruation, repeated pregnancy loss, and other serious gynecological diseases. Recently, microRNAs (miRNAs) have attracted much more attention process exploring molecular mechanisms tumorigenesis. Furthermore, deregulated miRNAs had been reported play important roles ULM pathology.In this study, we assessed...
To evaluate the effect of different bone cement injection methods during percutaneous vertebroplasty(PVP) on vertebral morphology and diffusion.The clinical data 52 patients with single-segment osteoporotic compression fracture treated from January 2016 to December 2017 were retrospectively analyzed. The divided into hydraumatic group (28 cases) pusher (24 according method PVP. By comparing visual analogue scale(VAS), height anterior body, ratio, kyphosis angle before after operation...