A5101531116- Muscle Physiology and Disorders
- Cancer-related molecular mechanisms research
- Cardiomyopathy and Myosin Studies
- RNA modifications and cancer
- Pancreatic function and diabetes
- Ocular Surface and Contact Lens
- MicroRNA in disease regulation
- Atrial Fibrillation Management and Outcomes
- Mesenchymal stem cell research
- Acne and Rosacea Treatments and Effects
- Neurogenetic and Muscular Disorders Research
- Biotin and Related Studies
- RNA Research and Splicing
- Corneal Surgery and Treatments
- Prenatal Screening and Diagnostics
- Prostate Cancer Treatment and Research
- Allergic Rhinitis and Sensitization
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Cardiovascular and Diving-Related Complications
- Biomedical Ethics and Regulation
- Polyamine Metabolism and Applications
- Circular RNAs in diseases
- Diabetes and associated disorders
- Pregnancy and preeclampsia studies
Sun Yat-sen University
2013-2025
Third Affiliated Hospital of Nanchang University
2023-2024
Nanchang University
2023-2024
Huazhong University of Science and Technology
2024
Union Hospital
2024
First Affiliated Hospital of Jiangxi Medical College
2023
Shaanxi Normal University
2023
Wenzhou Medical University
2023
Guangdong Province Women and Children Hospital
2019-2022
Baoji City Central Hospital
2016-2022
In vitro hypoxic preconditioning (HP) of mesenchymal stem cells (MSCs) could ameliorate their viability and tissue repair capabilities after transplantation into the injured through yet undefined mechanisms. There is also experimental evidence that HP enhances expression both stromal-derived factor-1 (SDF-1) receptors, CXCR4 CXCR7, which are involved in migration survival MSCs vitro, but little known about role vivo therapeutic effectiveness renal ischemia/reperfusion (I/R) injury. Here, we...
Abstract Background The identification of cell-free fetal DNA (cffDNA) facilitated non-invasive prenatal screening (NIPS) through analysis cffDNA in maternal plasma. However, challenges regarding its clinical implementation become apparent. Factors affecting fraction should be clarified to guide application. Results A total 13,661 pregnant subjects with singleton pregnancies who undertook NIPS were included the study. Relationship gestational age, BMI, and age plasmas for was investigated....
Circadian rhythm plays a critical role in the progression of autoimmune diseases. While our previous study demonstrated therapeutic effects melatonin experimental uveitis, involvement circadian remained unclear. Using light-induced disruption model, we showed that disrupted rhythms exacerbate uveitis by impairing stability and function Treg cells. Mechanistically, identified core clock gene Per1, which is significantly reduced under disruption, essential for cell metabolism immunoregulatory...
To determine how the lncRNA FER1L4 in ovarian cancer cells influences paclitaxel (PTX) resistance, we examined expression level of human epithelial cell lines IOSE80 and HOSEpiC OVCAR-3, Caov-3, SKOV3 through RNA isolation quantitative polymerase chain reaction (qRT-PCR). were treated with PTX. The survival rate apoptosis SKOV3-PR at different PTX dose levels evaluated. Next, qRT-PCR was performed to detect lines. transfected pcDNA3.1 as control group (SKOV3-PR/pcDNA3.1) or pcDNA3.1-FER1L4...
The current study aimed to analyze the effects of thyroid diseases on pregnancy outcomes and investigate levothyroxine (L-T4) tablets in treatment hypothyroidism. determined prevalence using two diagnostic criteria, among pregnant women recruited 2010 2014 were initially by 2011 Guidelines American Thyroid Association for Diagnosis Management Disease During Pregnancy Postpartum (2011 ATA Guidelines). Subjects categorized into six groups: Normal, hypothyroxinemia, hypothyroidism, subclinical...
Gastric cancer (GC) is the most common form of gastrointestinal cancer, with a high mortality rate and limited treatment options. High levels NEK2 are associated malignant progression poor prognosis in several tumors; however, role GC remains unclear. We aimed to explore potential oncogenesis shaping tumor microenvironment (TME). The expression were analyzed using immunohistochemistry real-time quantitative polymerase chain reaction. found that was upregulated predictor prognosis. Based on...
Insights into the mechanisms by which key factors stimulate cell growth under androgen-depleted conditions is a premise to development of effective treatments with clinically significant activity in patients castration-resistant prostate cancer (CRPC). Herein, we report that, expression Krüppel-like factor 14 (KLF14), master transcription regulation lipid metabolism, was significantly induced castration-insensitive PCa cells and tumor tissues from mouse xenograft model CRPC. KLF14...
It is unknown whether a scaffold containing both small intestinal submucosa (SIS) and mesenchymal stem cells (MSCs) for transplantation may improve pancreatic islet function survival. In this study, we examined the effects of SIS-MSC on survival in vitro vivo. MSCs islets were isolated from Sprague-Dawley rats, SIS was Bamei pigs. The apportioned among 3 experimental groups as follows: SIS-islets, SIS-MSC-islets control-islets. vitro, measured by glucose-stimulated insulin secretion test;...
Objectives The study aim was to determine the effect of an occupational blood-borne pathogen exposure (OBE) management program based on PRECEDE-PROCEED model knowledge, attitude and behaviour regarding OBE prevention among operating room nurses. Methods This a one-group pre-test post-test experimental study. used design evaluate 87 nurses from February July 2018. included pre-intervention assessment; risk factor analysis; interventions targeted predisposing, reinforcing enabling factors...
Sertoli cells are usually co-transplanted with pancreatic islets to induce local immune tolerance. In this report, we used infusion in islet transplantation systemic tolerance and studied the mechanism of induction.Streptozotocin-induced diabetic rats were divided into four groups before transplantation: group A as control; B intravenous cells; C cell Fas ligand antibody treatment; D transforming growth factor-beta1 treatment. The mean survival time (MST) insulin expression grafts measured....
This paper aims to extend the extant (primarily Western) organizational culture literature emerging economies by explicitly incorporating two key contextual variables-ownership type and firm size into model. Based on theoretical model developed Denison his colleagues, we examined impact of ownership culture, as well moderating effect variables linkage between effectiveness. Using survey data from foreign-invested state-owned firms in China, find that have significant influence culture. We...
Abstract Objective To evaluate the association between fetal fraction of cell‐free DNA at second trimester and subsequent spontaneous preterm birth. Methods In this retrospective cohort study, data were collected from women with singleton pregnancies who underwent noninvasive prenatal testing 14 to 25 weeks gestation. The eligible patients classified into three groups according pregnancy outcome: birth ≥37 gestation (term group), delivery <34 (early preterm), 34 +0 36 +6 (late preterm)....