Clemens Bloetzer
A5014572993- Muscle Physiology and Disorders
- Muscle activation and electromyography studies
- Nutritional Studies and Diet
- Prosthetics and Rehabilitation Robotics
- Blood Pressure and Hypertension Studies
- Neurogenetic and Muscular Disorders Research
- Children's Physical and Motor Development
- Birth, Development, and Health
- Obesity, Physical Activity, Diet
- Health Promotion and Cardiovascular Prevention
- Genetic Neurodegenerative Diseases
- Cardiomyopathy and Myosin Studies
- Sodium Intake and Health
- Child Nutrition and Feeding Issues
- Epilepsy research and treatment
- Advanced Sensor and Energy Harvesting Materials
- Renal function and acid-base balance
- Stroke Rehabilitation and Recovery
- Cardiovascular Health and Risk Factors
- Health, Environment, Cognitive Aging
- Muscle and Compartmental Disorders
- Neurology and Historical Studies
- RNA modifications and cancer
- Sleep and Wakefulness Research
- Cardiovascular Health and Disease Prevention
Institute of Social and Preventive Medicine
2014-2018
University of Bern
2017-2018
University of Lausanne
2012-2017
Children's Hospital of Philadelphia
2017
University Hospital of Lausanne
2010-2016
Hôpital Orthopédique de la Suisse Romande
2012
Service de la Santé Publique
2007
Analyzing the type and frequency of patient-specific mutations that give rise to Duchenne muscular dystrophy (DMD) is an invaluable tool for diagnostics, basic scientific research, trial planning, improved clinical care. Locus-specific databases allow collection, organization, storage, analysis genetic variants disease. Here, we describe development TREAT-NMD DMD Global database (http://umd.be/TREAT_DMD/). We analyzed data 7,149 held within database. A total 5,682 large were observed (80%...
Background: Recent short-term clinical trials in patients with Duchenne Muscular Dystrophy (DMD) have indicated greater disease variability terms of progression than expected. In addition, as average life-expectancy increases, reliable data is req
Duchenne muscular dystrophy (DMD) is an X-linked genetic disease, caused by the absence of dystrophin protein. Although many novel therapies are under development for DMD, there currently no cure and affected individuals often confined to a wheelchair their teens die in twenties/thirties. DMD rare disease (prevalence <5/10,000). Even largest countries do not have enough patients rigorously assess therapies, unravel complexities, determine patient outcomes. TREAT-NMD worldwide network...
In Duchenne muscular dystrophy (DMD), progressive loss of respiratory function leads to restrictive pulmonary disease and places patients at significant risk for severe complications. Of particular concern are ineffective cough, secretion retention recurrent tract infections. a Phase 3 randomized controlled study (DMD Long-term Idebenone Study, DELOS) in DMD 10–18 years age not taking concomitant glucocorticoid steroids, idebenone (900 mg/day) reduced significantly the over 1-year period....
Pulmonary function loss in patients with Duchenne muscular dystrophy (DMD) is progressive and leads to pulmonary insufficiency. The purpose of this study 10–18 year old DMD the assessment inter-correlation between tests (PFTs), their reliability association general disease stage measured by Brooke score. Dynamic PFTs (peak expiratory flow [PEF], forced vital capacity [FVC], volume one second [FEV1]) maximum static airway pressures (MIP, MEP) were prospectively collected from 64 enrolled...
Abstract Aim: Determine the frequency and predictors of sleep disorders in boys with Duchenne Muscular Dystrophy (DMD). Method: Cross‐sectional study by postal questionnaire. Sleep disturbances were assessed using Disturbance Scale for Children (validated on 1157 healthy children). A total score six disturbance factors representing most common computed. Potential associations between pathological scores personal, medical environmental assessed. Results: Sixteen 63 (25.4%) had a compared 3%...
Several guidelines recommend universal screening for hypertension in childhood and adolescence. Targeted to children with parental history of could be a more efficient strategy than screening. Therefore, we assessed the association between children, estimated sensitivity, specificity, negative, positive predictive values children.The present study was school-based cross-sectional including 5207 aged 10-14 years from all public 6th grade classes Canton Vaud, Switzerland. Children had if they...
Targeted screening of hypertension in childhood might be more efficient than universal screening. We estimated the sensitivity, specificity, negative and positive predictive values combined parental history overweight/obesity for diagnosis 5207 children aged 10-14 years. Children had if they sustained elevated blood pressure over three separate visits. The prevalence was 2.2%. 14% were overweight or obese, 20% a at least one parent 30% either both conditions. to with hypertensive parents...
Blood pressure (BP) screening is advocated in children. However, identification of children with sustained elevated BP difficult because high variability. We assessed the tracking and persistence across childhood adolescence.Three cohorts from schools Seychelles were examined on two occasions at 3-4-year intervals. Obesity was defined as BMI least 95th sex-specific, age-specific percentile. On each visit, based average readings age-specific, height-specific percentile.Data collected 4519...
Objective: As universal screening of hypertension performs poorly in childhood, targeted to children at higher risk has been proposed. Our goal was assess the performance combined parental history and overweight/obesity identify with hypertension. We estimated sensitivity, specificity, negative positive predictive values for identification children. Design method: analyzed data from a school-based cross-sectional study including 5207 aged 10 14 years all public 6th grade classes canton Vaud,...
Background Several guidelines recommend universal screening for hypertension in childhood and adolescence the early prevention of cardiovascular diseases. However, this recommendation has been challenged. Targeting toward children with a family history proposed. Our goals were to assess association between parental estimate performance (i.e., …
Kardiovaskuläre Risikofaktoren entwickeln sich bereits bei Kindern und erhöhen das Risiko für kardiovaskuläre Erkrankungen im Erwachsenenalter. Aufgrund dieser Beobachtungen wird gelegentlich vorgeschlagen, ein universelles Screening auf wie Hypertonie oder Dyslipidämie durchzuführen. Ist Kindesalter zu empfehlen?
Les facteurs de risque cardiovasculaire se développent dès l’enfance et augmentent le maladies cardiovasculaires à l’âge adulte. Sur la base ces observations, dépistage universel comme l’hypertension ou dyslipidémie est parfois proposé chez les enfants. Faut-il recommander un des l’enfance?