A5101822773- RNA modifications and cancer
- Prenatal Screening and Diagnostics
- Glioma Diagnosis and Treatment
- Hepatitis B Virus Studies
- Cancer-related Molecular Pathways
- Hepatitis C virus research
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Meningioma and schwannoma management
- RNA Research and Splicing
- Fetal and Pediatric Neurological Disorders
- Cancer Mechanisms and Therapy
- Epigenetics and DNA Methylation
- Renal and related cancers
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Brain Metastases and Treatment
- Autophagy in Disease and Therapy
- Microtubule and mitosis dynamics
- Parvovirus B19 Infection Studies
- MicroRNA in disease regulation
- Head and Neck Surgical Oncology
- Pituitary Gland Disorders and Treatments
- Immune Cell Function and Interaction
Guangdong Province Women and Children Hospital
2016-2025
Guangxi Medical University
2025
Sun Yat-sen University
2017-2024
The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture
2024
South China University of Technology
2022-2024
Sun Yat-sen Memorial Hospital
2022-2024
Wannan Medical College
2024
University of British Columbia
2024
Third Affiliated Hospital of Sun Yat-sen University
2017-2023
Guangdong Ocean University
2022-2023
C-C motif chemokine ligand 14 (CCL14) is a promoting the activation of immune cells. However, relationship between CCL14 expression, tumor immunity, and prognosis in Hepatocellular Carcinoma (HCC) remain unclear. expression its influence on were analyzed by ONCOMINE, Tumor Immune Estimation Resource (TIMER) Kaplan-Meier plotter. The immunity TIMER Gene Expression Profiling Interactive Analysis (GEPIA). was significantly lower several human cancers, including HCC, than corresponding normal...
MiRNAs are involved in aberrant DNA methylation through regulation of methyltransferases (DNMTs) the pathogenesis and progression glioblastomas (GBM). MiR-152-3p was down-expressed human malignancies, served as a tumor suppressor. Neurofibromatosis type 2 (NF2) significantly decreased GBM tissues with high level methylation. However, link between miR-152-3p, DNMT1 NF2 is not clearly established. This study conducted to detect mechanism GBM. The levels expression were studied by qRT-PCR,...
G2 and S phase-expressed-1 (GTSE1) regulates G1/S cell cycle transition. It was recently reported to be overexpressed in certain human cancers, but its significance mechanism(s) hepatocellular carcinoma (HCC) remain unknown. Here, we showed preferential GTSE1 upregulation HCC tissues lines that positively correlated with Ki67. knockdown by short hairpin RNA resulted deficient colony-forming ability depleted capabilities of cells migrate invade. Conversely, exogenous overexpression enhanced...
Abstract Hepatocellular carcinoma (HCC) is the third most frequent cause of cancer-related death worldwide, and molecular pathogenesis development HCC are largely unknown. In present study, we found that KIF4A expression was upregulated in (678 samples, P = 2.03E-8) based on a meta-analysis Oncomine database. We further confirmed both mRNA protein expressions were overexpressed human tumour tissues as well cancer cell lines. Higher correlated with poorer overall survival ( < 0.0001)...
A growing body of evidence suggests that E2Fs, by regulating gene expression related to cell cycle progression and other cellular processes, play a pivotal role in human cancer. However, the distinct roles each E2F development treatment hepatocellular carcinoma (HCC) remain unknown. In present study, mRNA prognostic value different E2Fs HCC are analyzed.Transcriptional survival data patients with were obtained through ONCOMINE UALCAN databases. Survival analysis plots drawn Kaplan-Meier...
Chromobox (CBX) proteins are important components of epigenetic regulation complexes known to play key roles in hepatocellular carcinoma (HCC). Little is about the function distinct CBXs HCC. To address this issue, study investigated prognosis HCC using ONCOMINE, UALCAN, Human Protein Atlas, Kaplan-Meier Plotter, c-BioPortal databases. Over expressions 8 members were found be significantly associated with clinical cancer stages and pathological tumor grades patients. Besides, higher mRNA...
Procollagen-lysine, 2-oxoglutarate 5-dioxygenases (PLODs) are a set of enzymes involved in the hydroxylation lysine and stabilization collagen by crosslinks. Previous studies have highlighted that overexpressing PLOD genes were related to progression, migration progression different human cancers. However, diverse expression patterns prognostic values remain be elucidated gastric cancer (GC). In this study, we mined survival data GC patients through ONCOMINE, UALCAN Kaplan-Meier Plotter...
Background: Prenatal diagnosis of fetal short long bones (SLBs) was reported to be associated with skeletal dysplasias, chromosomal abnormalities, and genetic syndromes. This study aims identify the causes for bones, retrospectively evaluate additional diagnostic yield exome sequencing (ES) following use conventional testing. Methods: A cohort ninety-four fetuses sonographically identified analyzed by trio-exome between January 2016 June 2021. Fetuses abnormal results karyotype or microarray...
To determine the oncogenic role of sixth subunit chaperonin-containing tailless complex polypeptide 1 (CCT6A) in hepatocellular carcinoma (HCC) and address correlation CCT6A with clinicopathological characteristics survival. Additionally, this study aimed to explore effect on HCC cells underlying mechanisms. We searched for levels expression Oncomine database GEPIA database, which was then validated by analyzing cancer adjacent non-cancerous tissues patients using quantitative PCR, Western...
Abstract Background ALG8-congenital disorder of glycosylation (ALG8-CDG) is a rare inherited metabolic leading to severe multisystem manifestations, with no reported prenatal patients date. Methods We describe two fetuses from single family ALG8-CDG presenting hydrops, undergoing comprehensive ultrasound, umbilical cord blood biochemistry, autopsy, placental pathology, and genetic testing. Results Prenatal ultrasound revealed fetal skeletal anomalies, cardiac developmental abnormalities,...
ABSTRACT Objective The primary aim of this research was to establish normative values for nuchal translucency (NT) thickness with crown‐rump length (CRL) ranging from 45 80 mm in a representative sample the Chinese population. Methods distributions NT were derived 24,892 unaffected fetuses CRL between and mm. relationship fetal assessed using linear regression analysis. Results equation describing was: = 0.020 × + 0.218, ( R 2 0.112, p < 0.001). 50th percentile ranged 1.12 1.82 95th 1.89...
<title>Abstract</title> <bold>Objective</bold> To evaluate the clinical efficacy, aesthetic outcomes, and safety profiles of volume displacement oncoplastic breast-conserving surgery (VD-OBCS) versus replacement (VR-OBCS) utilizing pedicled chest wall perforator flaps in breast cancer patients.<bold>Methods</bold> This retrospective cohort study enrolled 75 patients undergoing between February 2021 August 2022. Patients were stratified into two groups: VR-OBCS (n = 38) VD-OBCS 37)....
Calcyclin-binding protein (CACYBP) is a multi-ligand implicated in the progression of various human cancers.However, its function hepatocellular carcinoma (HCC) remains unknown.Methods: The expression CACYBP and RNF41 (RING finger 41) HCC cancer adjacent non-tumor tissues was detected by immunohistochemistry. CCK-8 assays, colony formation flow cytometry detection xenograft models were used to evaluate impact on cell growth, apoptosis cycle regulation.Immunoprecipitation ubiquitination...
Abstract Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous malignancy with poor prognosis. This article aims to explore the clinical significance of differentiation trajectory in HNSCC, identify different molecular subtypes by consensus clustering analysis, develop prognostic risk model on basis differentiation-related genes (DRGs) for predicting prognosis HNSCC patients. Firstly, analysis was performed single-cell RNA sequencing (scRNA-seq) data, four were identified...
Despite remarkable advancements in cancer immunotherapy, the overall response rate to anti-programmed cell death-1 (anti-PD-1) therapy hepatocellular carcinoma (HCC) patients remains low. Our previous study has demonstrated critical role of CacyBP/SIP (Calcyclin-Binding Protein and Siah-1 Interacting Protein) as a regulator HCC development progression. However, possible impact CacyBP on tumor immune microenvironment not yet been clarified.The expressions Myd88 lines tissues was detected by...
Abstract Esophageal squamous cell carcinoma (ESCC) is a highly prevalent and aggressive malignancy, timely diagnosis of ESCC contributes to an increased cancer survival rate. However, current detection methods for mainly rely on endoscopic examination, limited by relatively low participation Herein, ferric‐particle‐enhanced laser desorption/ionization mass spectrometry (FPELDI MS) utilized record the serum metabolic fingerprints (SMFs) from retrospective cohort (523 non‐ESCC participants 462...
Abstract Background Genetic disorders often manifest as abnormal fetal or childhood development. Copy number variations (CNVs) represent a significant genetic mechanism underlying such disorders. Despite their importance, the effectiveness of clinical exome sequencing (CES) in detecting CNVs, particularly small ones, remains incompletely understood. We aimed to evaluate detection both large and CNVs using CES substantial cohort, including parent–offspring trios proband only analysis. Methods...
Trophinin-associated protein (TROAP) was a first identified to mediate the process of embryo transplantation and later found be involved in microtubule regulation. However, little is known about role TROAP hepatocellular carcinoma (HCC). In present study, we reported that both mRNA expressions were downregulated human HCC samples as well cell lines. A high level associated with small tumor size (p < 0.05), minor nodules (p < 0.01), mild vein invasion (p < 0.05). We further constructed vitro...
The GINS complex is one of the core components eukaryotic replicative helicase CMG (Cdc45-MCM helicase-GINS) that serves as unwinding duplex DNA ahead moving replication fork during chromosome duplication. Many studies have highlighted important functions amongst subunits in various cancers. Nevertheless, and prognostic roles distinct hepatocellular carcinoma (HCC) were largely unexplored. In present study, we reported values HCC patients through analysis several databases, including...
Hepatitis B virus (HBV) replicates non-cytopathically in the hepatocytes and HBV-related diseases are caused by immune-mediated inflammatory events. This study aimed to identify relationship between clinical-virological characteristics immunity untreated chronic hepatitis (CHB) patients. A total of 209 CHB patients were categorized into immune tolerant (IT, n = 17), inactive carrier (IC, 20), active (IA, 120), gray zone (GZ, 72) phases. The quantitative surface antigen (qHBsAg), e (HBeAg),...
Abstract Aims: A large number of studies have suggested that exportins (XPOs) play a pivotal role in human cancers. In the present study, we analyzed XPO mRNA expression cancer tissues and explored their prognostic value hepatocellular carcinoma (HCC). Methods: Transcriptional survival data related to HCC patients were obtained through ONCOMINE UALCAN databases. Survival analysis plots drawn with Gene Expression Profiling Interactive Analysis (GEPIA). Sequence alteration for XPOs from The...