A5068301817- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Liver Disease and Transplantation
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 diagnosis using AI
- Long-Term Effects of COVID-19
- Organ Transplantation Techniques and Outcomes
- Epigenetics and DNA Methylation
- Viral gastroenteritis research and epidemiology
- Drug Transport and Resistance Mechanisms
- Ferroptosis and cancer prognosis
- Hepatitis Viruses Studies and Epidemiology
- Evolution and Genetic Dynamics
- Mathematical and Theoretical Epidemiology and Ecology Models
- COVID-19 epidemiological studies
- SARS-CoV-2 detection and testing
- Single-cell and spatial transcriptomics
- Clinical Nutrition and Gastroenterology
- Inflammation biomarkers and pathways
- RNA modifications and cancer
- Cancer-related gene regulation
- Autophagy in Disease and Therapy
- Bone fractures and treatments
Third Affiliated Hospital of Sun Yat-sen University
2017-2025
Sun Yat-sen University
2017-2025
Xiamen University
2023
Dahua Technology (China)
2022
The People's Hospital of LinXia
2015
Xi'an Jiaotong University
2013-2014
Because there is no reliable risk stratification tool for severe coronavirus disease 2019 (COVID-19) patients at admission, we aimed to construct an effective model early identification of cases high progression COVID-19.In this retrospective multicenter study, 372 hospitalized with nonsevere COVID-19 were followed > 15 days after admission. Patients who deteriorated or critical and those maintained a state assigned the groups, respectively. Based on baseline data 2 constructed prediction...
Abstract Purpose The purpose of this study was to detect severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) ribonucleic acid (RNA) in urine and blood specimens, anal oropharyngeal swabs from patients with confirmed SARS‐CoV‐2 infection, correlated positive results clinical findings. Methods Patients infections were included study. Patients' demographic data recorded. Quantitative real‐time polymerase chain reaction used RNA swabs. is registered at ClinicalTrials.gov (No....
Abstract Background Due to no reliable risk stratification tool for severe corona virus disease 2019 (COVID-19) patients at admission, we aimed construct an effective model early identifying cases high of progression COVID-19. Methods In this retrospective three-centers study, 372 non-severe COVID-19 during hospitalization were followed more than 15 days after admission. Patients who deteriorated or critical and kept state assigned the group, respectively. Based on baseline data two groups,...
Abstract We tested samples collected from nine patients diagnosed with coronavirus disease 2019 (COVID-19). The virus was found in urine, blood, anal swabs and oropharyngeal swabs. It is the first time for SARS-CoV-2 though no urinary irritation found.
SARS-CoV-2, the causative agent for COVID-19, infect human mainly via respiratory tract, which is heavily inhabited by local microbiota. However, interaction between SARS-CoV-2 and nasopharyngeal microbiota, association with metabolome has not been well characterized. Here, metabolomic analysis of blood, urine, swabs from a group COVID-19 non-COVID-19 patients, metagenomic pharyngeal samples were used to identify key features COVID-19. Results showed lactic acid, l-proline, chlorogenic acid...
Background . Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a common type of with high mortality. This study aimed at investigating the safety and efficacy combination treatment plasma exchange (PE) umbilical cord-derived mesenchymal stem cell (UC-MSCs) transplantation for HBV-ACLF patients. Methods A total 110 patients treated in our hospital from January 2012 to September 2017 were enrolled into this trial divided control group (<mml:math...
Chromobox (CBX) proteins are important components of epigenetic regulation complexes known to play key roles in hepatocellular carcinoma (HCC). Little is about the function distinct CBXs HCC. To address this issue, study investigated prognosis HCC using ONCOMINE, UALCAN, Human Protein Atlas, Kaplan-Meier Plotter, c-BioPortal databases. Over expressions 8 members were found be significantly associated with clinical cancer stages and pathological tumor grades patients. Besides, higher mRNA...
Current evidence suggests that the mortality rate of intermediate-stage hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF) remains high. We aimed to investigate safety and efficacy double plasma molecular adsorption system (DPMAS) with sequential low-volume exchange (LPE) treatment in HBV-related ACLF. This prospective study recruited ACLF patients was registered on ClinicalTrials.gov (NCT04597164). Eligible were randomly divided into a trial group control group. Patients...
Summary Background and Aims For chronic hepatitis B (CHB) patients, there is still a need to improve surface antigen (HBsAg) clearance rates. This study aimed assess the predictive effectiveness of soluble programmed cell death‐1 (sPD‐1) death ligand‐1 (sPD‐L1) for HBsAg in HBeAg‐negative CHB patients undergoing peginterferon (Peg‐IFN)‐based antiviral treatment. Methods encompassed 280 treatment with Peg‐IFNα. Serum levels sPD‐1 sPD‐L1 were measured using ELISA kits at baseline, as well 12,...
Abstract Ribosome biogenesis (RiboSis) and ribosomal stress are critical in tumor progression, positioning RiboSis as a promising therapeutic target for cancer treatment overcoming drug resistance. In this study, we examined the role of progression from hepatitis B virus (HBV) infection to HBV-related hepatocellular carcinoma (HCC), focusing specifically on nucleolar protein 9 (NOL9) its influence HCC pathogenesis response. Our findings showed that NOL9 was significantly upregulated tissues,...
The long-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is not well characterised. We assessed outcomes and the associated risk factors HBV-ACLF in southern China. retrospectively analysed clinical data, adverse events, endpoint events treated at our department between January 2014 December 2018. A total 616 (52.3%) cirrhosis 561 (47.7%) without were included. In 973 (83%) patients, disease was only HBV, while 204 (17%) had two or more...
Hepatitis B virus (HBV) is an enveloped DNA that causes chronic hepatitis (CHB) infection. Annexin, a Ca2+-activated protein, widely expressed in various organs and tissues has potential utility disease diagnosis treatment. However, the relationship between annexin family CHB remains unclear. Clinical samples from patients donors or healthy individuals were collected. Transcriptome sequencing liver HBV-infected cells performed. HepG2.2.15 with full-length HBV genome HepG2-NTCP cell models...
Launching, tracking, and controlling picosecond acoustic (PA) pulses are fundamentally important for the construction of ultrafast hypersonic wave sources, manipulation matter, spatiotemporal imaging interfaces. Here, we show that GHz PA can be all-optically generated, detected, manipulated in a 2D layered MoS 2 /glass heterostructure using femtosecond laser pump–probe. Based on an interferometric model, pulse signals glass successfully decoupled from coexisting temperature photocarrier...
The recently-described sodium taurocholate co-transporting polypeptide (NTCP) acts as a receptor for the hepatitis B virus (HBV) on host hepatocytes. We aim to investigate how NTCP p.Ser267Phe variant affects HBV-related disease progression and analyze viral genomic variability under genetic background carrying variant. A total of 3187 chronic (CHB) patients were enrolled genotyped variant's association with was evaluated by logistic regression analysis. also 83 treatment-naive CHB HBV preS1...
We present an SEIS epidemic model with infective force in both latent period and infected period, which has different general saturation incidence rates. It is shown that the global dynamics are completely determined by basic reproductive number <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msub><mml:mi>R</mml:mi><mml:mn>0</mml:mn></mml:msub></mml:mrow></mml:math>. If...
Alpha virus M1 is an oncolytic that targets zinc-finger antiviral protein (ZAP)-defective cancer cells, and may be useful for treatment of hepatocellular carcinoma (HCC). Most HCC patients have hepatitis need long-term medication. Thus, it necessary to clarify whether anti-virus medicines influence effect M1. We examined the drugs used treat B/C on M1-mediated oncolysis in vitro vivo. Interferon (IFN)-α induces expression IFN-stimulated genes (ISGs) cells with moderate sensitivity virus....
Single nucleotide polymorphism (SNP) of complement component 2 (C2) has been found to be significantly associated with hepatocellular carcinoma (HCC). However, little is known about the role and mechanism C2 in HCC. In present study, we aimed explore prognostic value its correlation tumor-infiltrating immune cells HCC.mRNA expression was downloaded from TCGA (365 HCC patients 50 healthy controls), GSE14520 (220 220 adjacent normal tissues), ICGC (232 patients) cohorts. Unpaired Student's...
To investigate the safety and efficacy of double plasma molecular adsorption system (DPMAS) with sequential low-dose exchange (LPE) in treating early hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF).Clinical data patients HBV-ACLF were prospectively collected, including a DPMAS LPE (DPMAS+LPE) group those standard medical treatment (SMT) group. The primary endpoint was death or transplantation (LT) at 12 weeks follow-up. Propensity-score matching performed to control...