A5010503192- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Liver Disease and Transplantation
- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- Hepatitis Viruses Studies and Epidemiology
- Immunotherapy and Immune Responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Polyoxometalates: Synthesis and Applications
- Advancements in Battery Materials
- Viral gastroenteritis research and epidemiology
- Peptidase Inhibition and Analysis
- Advanced Nanomaterials in Catalysis
- Supercapacitor Materials and Fabrication
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune responses and vaccinations
- Advanced Glycation End Products research
- Nutrition and Health in Aging
- Kruppel-like factors research
- Liver physiology and pathology
- Autoimmune Neurological Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Inflammasome and immune disorders
China-Japan Friendship Hospital
2018-2025
Third Affiliated Hospital of Sun Yat-sen University
2011-2024
Sun Yat-sen University
2012-2024
Longyan University
2024
Wuhan University of Science and Technology
2018
Harbin University of Science and Technology
2010-2014
Current evidence suggests that the mortality rate of intermediate-stage hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF) remains high. We aimed to investigate safety and efficacy double plasma molecular adsorption system (DPMAS) with sequential low-volume exchange (LPE) treatment in HBV-related ACLF. This prospective study recruited ACLF patients was registered on ClinicalTrials.gov (NCT04597164). Eligible were randomly divided into a trial group control group. Patients...
Summary Background and Aims For chronic hepatitis B (CHB) patients, there is still a need to improve surface antigen (HBsAg) clearance rates. This study aimed assess the predictive effectiveness of soluble programmed cell death‐1 (sPD‐1) death ligand‐1 (sPD‐L1) for HBsAg in HBeAg‐negative CHB patients undergoing peginterferon (Peg‐IFN)‐based antiviral treatment. Methods encompassed 280 treatment with Peg‐IFNα. Serum levels sPD‐1 sPD‐L1 were measured using ELISA kits at baseline, as well 12,...
Infection with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) may target the central nervous system and several neurological symptoms have been reported in patients disease 2019 (COVID‑19). In present study, a case of SARS‑CoV‑2 complicated meningoencephalitis was reported. Cerebrospinal fluid (CSF) analyses indicated hyperproteinorrachia but specimen negative for RNA. Furthermore, 10 published articles reporting on COVID‑19‑associated meningitis/encephalitis were reviewed....
Egg production is an important economic trait in layer ducks and understanding the genetics basis for their breeding. In this study, a genome-wide association study (GWAS) egg traits 303 female Longyan Shan-ma was performed based on genotyping-by-sequencing strategy. Sixty-two single nucleotide polymorphisms (SNPs) associated with weight were identified (P < 9.48 × 10
Neuromyelitis optica (NMO) spectrum disorder (NMOSD) is a devastating autoimmune inflammatory of the central nervous system, which can result in blindness or paralysis. Currently, there dire need for new treatment options clinic. Several case series have shown that mycophenolate mofetil (MMF) may be an effective NMOSD patients. The dosing MMF has been poorly studied. Therefore, we evaluated efficacy, tolerability, influential factors and optimal dosage Chinese patients with NMOSD.A 109 NMO...
Little is known about the mechanisms of IL-17 secreting T cells accumulation in HBV-transfected livers. Here, we investigated role chemokines CCL17, CCL20 and CCL22 this process.Peripheral blood liver tissues were obtained from 30 chronic hepatitis B (CHB) patients 15 healthy volunteers evaluated by flow cytometric analysis immunohistochemistry. Chemokine production monocyte-derived dendritic (MoDCs) cocultured with or untransfected Huh7 was measured quantitative real-time PCR enzyme-linked...
The long-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is not well characterised. We assessed outcomes and the associated risk factors HBV-ACLF in southern China. retrospectively analysed clinical data, adverse events, endpoint events treated at our department between January 2014 December 2018. A total 616 (52.3%) cirrhosis 561 (47.7%) without were included. In 973 (83%) patients, disease was only HBV, while 204 (17%) had two or more...
Introduction Malnutrition is a common complication of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) typically associated with poor prognosis. Despite nutritional treatment, the outcomes for these patients are limited by symptoms and complications ACLF. So far, benefits interventions in populations have not been proven. This study aims to explore new intervention method HBV-ACLF evaluate its safety efficacy. Methods analysis an investigator-initiated, nonblind,...
More than 170 million individuals worldwide are infected with hepatitis C virus (HCV), and up to an estimated 30% of chronically will go on develop progressive liver disease. Despite the recent advances in antiviral treatment HCV infection, it remains a major public health problem. Thus, development effective vaccine is urgently required. In this study, we constructed novel adeno-associated (AAV) vectors expressing full-length NS3 or NS3/4 protein genotype 1b. The expression HepG2 cells was...
Neuromyelitis optica spectrum disorder (NMOSD) is a devastating autoimmune with cycles of escalating relapse. Rates diagnosis in the elderly are increasing. Therapeutic decision-making more challenging patients due to multiple comorbidities and high risk drug-induced side effects.This retrospective study assessed efficacy safety standard plasma exchange (PLEX) treatment an population NMOSD.Seventy-six NMOSD who received PLEX were apportioned two groups as either (⩾60 years, n = 26) or young...
Tenofovir alafenamide (TAF) has been available in China for a short time, little is known about its safety and efficacy patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (HBV-ACLF). We conducted this study to further verify the of TAF these patients. Eighty-eight eligible subjects were included divided into three groups: group, TDF group ETV group. Clinical laboratory test results collected survival status, suppression status renal function improvement observed...
Background Tenofovir alafenamide (TAF) is a new anti-hepatitis B virus nucleotide analogue that can cause dyslipidaemia in AIDS patients, but the effect of TAF on blood lipids patients with chronic hepatitis (CHB) unknown. This study aimed to evaluate lipid levels CHB. Methods One hundred and twenty-one CHB were recruited as group, including 69 treatment-naïve 52 nucleoside/nucleotide experience before treatment. All followed up regularly for 48 weeks. Total cholesterol (TC), low-density...