A5050874335- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Hepatitis C virus research
- Liver Disease and Transplantation
- Endoplasmic Reticulum Stress and Disease
- Vaccine Coverage and Hesitancy
- Hippo pathway signaling and YAP/TAZ
- Pneumonia and Respiratory Infections
- RNA and protein synthesis mechanisms
- Clinical Nutrition and Gastroenterology
- RNA modifications and cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Cancer Cells and Metastasis
- Glaucoma and retinal disorders
- Spinal Hematomas and Complications
- Economic and Financial Impacts of Cancer
- Spine and Intervertebral Disc Pathology
- Ferroptosis and cancer prognosis
- Bacterial Infections and Vaccines
- Magnesium in Health and Disease
- Heart Failure Treatment and Management
- ATP Synthase and ATPases Research
- Liver physiology and pathology
- Cancer-related gene regulation
University of Science and Technology of China
2024
Third Affiliated Hospital of Sun Yat-sen University
2016-2023
Sun Yat-sen University
2016-2023
Affiliated Hospital of Nantong University
2023
Yancheng First People's Hospital
2023
Xuzhou Medical College
2023
Nantong University
2023
Pfizer (China)
2020
Shanghai Centennial Scientific (China)
2019
Air Force Medical University
2013
Tumor-resident microbiota in breast cancer promotes initiation and malignant progression. However, targeting to improve the effects of therapy has not been investigated detail. Here, we evaluated composition tumors found that enterotoxigenic Bacteroides fragilis (ETBF) was highly enriched patients who did respond taxane-based neoadjuvant chemotherapy. ETBF, albeit at low biomass, secreted toxic protein BFT-1 promote cell stemness chemoresistance. Mechanistic studies showed directly bound...
Background . Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a common type of with high mortality. This study aimed at investigating the safety and efficacy combination treatment plasma exchange (PE) umbilical cord-derived mesenchymal stem cell (UC-MSCs) transplantation for HBV-ACLF patients. Methods A total 110 patients treated in our hospital from January 2012 to September 2017 were enrolled into this trial divided control group (<mml:math...
Current evidence suggests that the mortality rate of intermediate-stage hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF) remains high. We aimed to investigate safety and efficacy double plasma molecular adsorption system (DPMAS) with sequential low-volume exchange (LPE) treatment in HBV-related ACLF. This prospective study recruited ACLF patients was registered on ClinicalTrials.gov (NCT04597164). Eligible were randomly divided into a trial group control group. Patients...
Abstract Background CELSR2 is postulated to be a receptor involved in contact-mediated communication; however, the specific function of this particular member has not been determined hepatocellular carcinoma (HCC). Methods Here, we explored expression and HCC patients through data mining examined results using clinical samples vitro experiments. Results It was found that mRNA protein levels were significantly higher cancerous tissue than normal tissue. The increased associated with overall...
Objective: As a main cellular component within the disc, nucleus pulposus (NP) cells play important roles in disc physiology.However, little is known on biologic hallmarks of human NP cells.Therefore, present study aimed to address features cells.Methods: Human samples were collected from normal cadavers, patients with scoliosis and degeneration as normal, disease control degenerative NP, respectively.The studied using transmission electron microscopy TUNEL assay.Pre-digested flow cytometry...
The aim of the present study was to investigate overexpression and significance ribosomal L1 domain containing 1 (RSL1D1) in prostate cancer (PCA). performed immunohistochemical analysis on tissues 138 patients with pathologically confirmed PCA. were followed up for a median 87 months. In addition, 50 benign prostatic hyperplasia (BPH) enrolled as control group. Of PCA tissue samples, 124 (89.9%) expressed RSL1D1, while 4 out (8.0%) BPH RSL1D1. defined high RSL1D1 expression level relative...
It is important to identify novel biomarkers improve hepatocellular carcinoma (HCC) diagnosis and treatment. Herein, we reported the role of karyopherin α4 (KPNA4) in HCC patients through public data mining examined results using clinical samples our center. Our revealed that KPNA4 expression level was positively correlated with infiltration CD8+ T cells, B dendritic CD4+ neutrophils macrophages. In addition, significantly associated cell exhaustion. mRNA protein levels were higher cancerous...
Sodium taurocholate cotransporting polypeptide (NTCP) acts as a cellular receptor for the hepatitis B virus infection of host hepatocytes. Previously, many studies confirmed that NTCP p.Ser267Phe variant was protective factor against HBV-related disease progression. We therefore designed this study to investigate whether exerts an additive anti-HBV effect in chronic (CHB) patients on mainstream NAs treatment. After propensity score matching (PSM), total 136 CHB were included, among whom 68...
The safety and efficacy of mesenchymal stem cells (MSCs) in the treatment acute-on-chronic liver failure (ACLF) have been validated. However, impact pathological ACLF microenvironment on MSCs is less well understood. This study was designed to explore changes functional properties exposed serum.MSCs were cultured presence 10%, 30% 50% serum concentrations from patients healthy volunteers. Then, cell morphology, phenotype, apoptosis proliferation evaluated, including immunosuppressive...
Objective To investigate the prognostic value of Model for End-Stage Liver Disease (MELD) score and Hepatic Encephalopathy (HE) short-term prognosis Hepatitis B virus-related Acute-on-Chronic Failure (HBV-ACLF) patients treated with plasma exchange (PE).Methods A total 108 HBV-ACLF PE were retrospectively enrolled between January 2014 to December 2020. Based on survival at 28 days, divided into (N = 87) death groups 21). Clinical data laboratory indicators analyzed.Results Compared group,...
Acute-on-chronic liver failure (ACLF) is a major cause of liver-related death worldwide, but its key pathological features remain incompletely defined. This study aimed to reveal the molecular basis hepatitis B virus-related ACLF (HBV-ACLF) by transcriptome sequencing human tissue. A total 18 tissues from patients with different stages HBV-related disease were collected for RNA sequencing, and mouse models used subsequent validation. Specifically, 6,853 differentially expressed genes (DEGs)...
Background: Congenital heart disease (CHD) is one of the most common birth defects. MicroR-NAs (miRNAs) are a group endogenous, non-coding small RNAs and mediate target genes expression. An increasing evidence showed that in recent years, miRNAs have given rise to more attention protection development. In our research, main purpose was determine effect miR-27b-3p CHD analyze related mechanisms. Methods: We performed qRT-PCR analysis examine expression myocardial tissue from 30 patients with...
Introduction Combination antiviral therapy of nucleos(t)ide analogue (NA) and pegylated interferon alpha (peg-IFN alpha) decrease hepatitis B virus (HBV) surface antigen (HBsAg) levels to achieve functional cure improve long-term prognosis in chronic patients. However, for B-related liver fibrosis, studies on combination these two medicines are limited. This study was designed compare the efficacy between peg-IFN combined with tenofovir (TDF) TDF monotherapy clearance HBsAg NA-experienced...
To evaluate the safety and efficacy of modified Ahmed glaucoma valve (AGV) implantation (long scleral tunnel technique) in treatment neovascularization (NVG). This retrospective observational case series included 23 patients (23 eyes) diagnosed with NVG secondary to proliferative diabetic retinopathy from January 2020 June 2021. All cases received anti-vascular endothelial growth factor treatment. Then, after 3 7 days, these were treated AGV followed up for at least 6 months. The best...