A5017022799- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Cancer Research and Treatments
- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Cytokine Signaling Pathways and Interactions
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Hippo pathway signaling and YAP/TAZ
- Cancer, Stress, Anesthesia, and Immune Response
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- Bone health and treatments
- Gene expression and cancer classification
- TGF-β signaling in diseases
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Signaling Pathways in Disease
North Sichuan Medical University
2025
Jiangxi Chest Hospital
2021-2025
University of Chinese Academy of Sciences
2016-2024
Shanghai Institute of Nutrition and Health
2014-2024
Zhuzhou Central Hospital
2021-2024
Central South University
2023-2024
Princeton University
2007-2023
Tongji Hospital
2023
Huazhong University of Science and Technology
2023
Shanghai Institutes for Biological Sciences
2012-2022
MicroRNAs are small non-coding RNA molecules that can regulate gene expression by interacting with multiple mRNAs and inducing either translation suppression or degradation of mRNA. Recently, several miRNAs were identified as promoters suppressors metastasis. However, it is unclear in which step(s) the multistep metastatic cascade these play a defined functional role. To study importance epithelial-mesenchymal transition (EMT), process thought to initiate metastasis enhancing motility tumor...
Lung metastasis is the major cause of breast cancer-related mortality. The neutrophil-associated inflammatory microenvironment aids tumor cells in metastatic colonization lungs. Here, we show that tumor-secreted protease cathepsin C (CTSC) promotes breast-to-lung by regulating recruitment neutrophils and formation neutrophil extracellular traps (NETs). CTSC enzymatically activates membrane-bound proteinase 3 (PR3) to facilitate interleukin-1β (IL-1β) processing nuclear factor κB activation,...
Bone metastasis is mediated by complex interactions between tumor cells and resident stromal in the bone microenvironment. The functions of metalloproteinases organ-specific remain poorly defined despite their well-appreciated role matrix degradation invasion. Here, we show a mechanism whereby two distinct metalloproteinases, disintegrin metalloproteinase with thrombospondin motifs (ADAMTS1) metalloproteinase-1 (MMP1), orchestrate paracrine signaling cascade to modulate microenvironment...
Abstract The utilization of upconverting nanophosphors (UCNP) for photodynamic therapy (PDT) has gained significant interests due to its ability convert deep‐penetrating near‐infra red (NIR) light (i.e., 978 nm) visible light. Previous attempts co‐localize UCNPs with photosensitizers suffer from low photosensitizer loading and problems nanoparticle aggregation. Here, the preparation a novel composite formulation comprising 100 nm β −NaYF 4 :Yb 3+ ,Er UCNPs, meso ‐tetraphenyl porphine (TPP)...
Abstract Lithium dendrite growth is one of the most challenging problems affecting safety performance lithium‐ion batteries (LIBs). It causes low Coulombic efficiency as well hazards for LIBs. Understanding evolution process Li‐dendrite at nanoscale critical solving this problem. Herein, an in situ electrochemical atomic force microscopy (EC‐AFM) investigation initial Li deposition ethylene carbonate (EC)‐based and fluoroethylene (FEC)‐based electrolytes on graphite anodes reported. These...
Improving the cyclic stability of lithium metal anodes is particular importance for developing high-energy-density batteries. In this work, a remarkable finding shows that control bis(fluorosulfonyl)imide (LiFSI) concentrations in electrolytes significantly alters thickness and modulus related SEI layers, leading to varied cycling performances Li anodes. an electrolyte containing 2 M LiFSI, layer ∼70 nm obviously thicker than those obtained other observed through situ atomic force microscopy...
The application of functional genomic analysis breast cancer metastasis has led to the identification a growing number organ-specific genes, which often function in concert facilitate different steps metastatic cascade. However, gene regulatory network that controls expression these genes remains largely unknown. Here, we demonstrate computational approach for deconvolution transcriptional networks discover master regulators bone metastasis. Several known such as Smad4 and HIF1 were...
Abstract The transforming growth factor β (TGFβ) pathway plays critical roles during cancer cell epithelial-mesenchymal transition (EMT) and metastasis. SMAD7 is both a transcriptional target negative regulator of TGFβ signalling, thus mediating feedback loop that may potentially restrain responses cells. Here, however, we show treatment induces transcription but not its protein level in panel Mechanistic studies reveal activates the expression microRNA-182 (miR-182), which suppresses...
Abstract Triple-negative breast cancer (TNBC) is highly heterogeneous and has a poor prognosis. It therefore important to identify the underlying molecular mechanisms in order develop novel therapeutic strategies. Although emerging research revealed long noncoding RNAs (lncRNA) as vital carcinogenesis progression, their functional involvement TNBC not been well defined. In this study, we utilized The Cancer Genome Atlas (TCGA) database analyzed clinical samples show that antisense transcript...
HERV loci transcribed lncRNA TROJAN promotes TNBC progression through ZMYND8 degradation by the ubiquitin-proteasome pathway.
Loss of phosphatase and tensin homolog (PTEN) activation the PI3K/AKT signaling pathway are hallmarks prostate cancer (PCa). However, these alterations alone insufficient for cells to acquire metastatic traits. Here, we have shown that histone dimethyl transferase WHSC1 critically drives indolent PTEN-null tumors become PCa. In a murine PCa model, overexpression in epithelium cooperated with Pten deletion produce metastasis-prone tumor. Conversely, genetic ablation Whsc1 prevented tumor...
Cancer stem-like cells (CSC) are a cell subpopulation that can reinitiate tumors, resist chemotherapy, and give rise to metastases. Metadherin (MTDH) contributes widely tumor growth, drug resistance, relapse, metastasis, but its molecular mechanisms of action not well understood. Here, we report MTDH drives CSC expansion by promoting the expression TWIST1, transcription factor critical for cancer stemness metastasis. activates TWIST1 indirectly facilitating histone H3 acetylation on...
Abstract Cancer stem-like cells (CSCs) are a subpopulation of cancer responsible for tumor growth, and recent evidence suggests that CSCs also contribute to metastasis. However, the heterogeneity in metastasis capacities is still unclear breast cancer. Here we show among CD24 − /CD44 + CSCs, subset expressing variant isoform CD44 (CD44v) displays significantly higher capacity lung than standard CD44s. Increasing or reducing CD44v/CD44s ratio by regulating expression epithelial splicing...
Abstract Disseminated tumor cells often fall into a long term of dormant stage, characterized by decreased proliferation but sustained survival, in distant organs before awakening for metastatic growth. However, the regulatory mechanism dormancy and is largely unknown. Here, we show that epithelial-like mesenchymal-like subpopulations breast cancer stem-like (BCSCs) demonstrate different levels tumorigenicity lungs. The non-coding RNA (lncRNA) NR2F1-AS1 ( NAS1 ) up-regulated BCSCs,...