A5101882183- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- Histone Deacetylase Inhibitors Research
- Cancer-related molecular mechanisms research
- Genetics and Neurodevelopmental Disorders
- Genetic Syndromes and Imprinting
- Energy Load and Power Forecasting
- Ubiquitin and proteasome pathways
- RNA and protein synthesis mechanisms
- Pluripotent Stem Cells Research
- Electric Power System Optimization
- Smart Grid and Power Systems
- Power Systems and Renewable Energy
- Immune cells in cancer
- Power Systems and Technologies
- Radio Frequency Integrated Circuit Design
- Optimal Power Flow Distribution
- Advancements in PLL and VCO Technologies
- Advanced Measurement and Metrology Techniques
- DNA Repair Mechanisms
- Power System Reliability and Maintenance
Fudan University
2016-2025
Zhongshan Hospital
2017-2025
Shanghai Medical College of Fudan University
2014-2025
Fudan University Shanghai Cancer Center
2016-2025
Huashan Hospital
2018-2022
Guangxi University
2007-2022
Pudong Medical Center
2022
Children's Hospital of Fudan University
2014-2019
Ministry of Science ICT and Future Planning
2019
Shangluo University
2019
A Lot of HOTAIR The roles several classes small (<50 nucleotides) noncoding RNAs are beginning to be defined in molecular detail, whereas the function most long (∼200+ nucleotides), intergenic (linc)RNAs found eukaryotic genomes remains something a mystery. lincRNA, which is transcribed from mouse HOXC locus, binds Polycomb Repressive Complex 2 (PRC2) and recruits it HOXD other genes, where its histone methylase activity acts repress gene transcription. Tsai et al. (p. 689 , published...
Epigenetic mechanisms mediate heritable control of cell identity in normal cells and cancer. We sought to identify epigenetic regulators driving the pathogenesis pancreatic ductal adenocarcinoma (PDAC), one most lethal human cancers. found that KDM2B (also known as Ndy1, FBXL10, JHDM1B), an H3K36 histone demethylase implicated bypass cellular senescence somatic reprogramming, is markedly overexpressed PDAC, with levels increasing disease grade stage, highest expression metastases. silencing...
Chronic endoplasmic reticulum (ER) stress is a major contributor to obesity-induced insulin resistance in the liver. However, molecular link between obesity and ER remains be identified. Proteasomes are important multicatalytic enzyme complexes that degrade misfolded oxidized proteins. Here, we report both mouse models of diabetes proteasome activator (PA)28-null mice showed 30–40% reduction activity accumulation polyubiquitinated proteins PA28-null also hepatic steatosis, decreased...
HERV loci transcribed lncRNA TROJAN promotes TNBC progression through ZMYND8 degradation by the ubiquitin-proteasome pathway.
UHRF1 (Ubiquitin-like, with PHD and RING finger domains 1) plays an important role in DNA CpG methylation, heterochromatin function gene expression. Overexpression of has been suggested to contribute tumorigenesis. However, regulation is largely unknown. Here we show that the deubiquitylase USP7 interacts UHRF1. Using interaction-defective catalytic mutants for complementation experiments, demonstrate both physical interaction activity are necessary ubiquitylation stability regulation. Mass...